4.4 Review

MDM4: What do we know about the association between its polymorphisms and cancer?

Related references

Note: Only part of the references are listed.
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Summary: This study found that two polymorphisms (rs1380576 and rs4245739) of the MDM4 gene are associated with susceptibility to ESCC in the high-incidence region of Cixian, but do not affect the survival of ESCC patients.

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Summary: This study conducted a meta-analysis to assess the connection between MDM4 polymorphisms and malignancies. The results showed that the rs4245739 polymorphism might reduce cancer susceptibility, especially in Asian populations, and it is a risk-reducing factor for esophageal squamous cell carcinoma (ESCC). However, the other four SNPs are not associated with cancer susceptibility.

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