Journal
DRUGS OF TODAY
Volume 58, Issue 12, Pages 577-589Publisher
PROUS SCIENCE, SAU-THOMSON REUTERS
DOI: 10.1358/dot.2022.58.12.3474538
Keywords
Pacritinib Myelofibrosis; Thrombocy-topenia; Janus kinase 2 (JAK2) inhibitors; Fms-like tyrosine kinase 3 (FLT3) inhibitors
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Myelofibrosis is a progressive cancer that disrupts the production of healthy blood cells, leading to bone marrow failure. Patients with severe thrombocytopenia have increased disease burden and limited treatment options. Pacritinib, a new oral kinase inhibitor, targets specific enzymes and is indicated for the treatment of myelofibrosis patients with platelet count below a certain level.
Myelofibrosis is a rare progressive cancer of the bone marrow that disrupts the normal production of healthy blood cells, leading to bone marrow failure. Patients with myelofibrosis and severe thrombocytopenia (platelet count below 50 x 109/L) have a wide range of unmet medical needs compared with those without thrombo-cytopenia. Usually, these patients have an increased disease burden, increased transfusion dependence, shorter overall survival, and limited treatment options. Pacritinib is a new oral kinase inhibitor specifically targeting Janus kinase2 (JAK2), interleukin-1 receptor -associated kinase 1 (IRAK-1) and colony-stimulating factor 1 receptor (CSF-1R), and is indicated for the treat-ment of adults with moderate or high risk of primary or secondary myelofibrosis (post-polycythemia or post -primary thrombocytopenia) whose platelet count is less than 50 x 109/L. In this review, we introduce pacri- tinib and make a brief comparison of different JAK inhi-bitors in clinical application.
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