Journal
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
Volume 123, Issue 1, Pages 1-8Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/13813455.2016.1160935
Keywords
Angiotensin-converting enzyme; angiotensin II receptor; cardiac gene expression; oral contraceptive; plasminogen activator inhibitor-1
Funding
- Basic Science Research Program through National Research Foundation of Korea (NRF) [2013R1A2A2A01005155, 2013K2A4A1044932, 2013K2A1B9061222]
- Ministry of Education, Science and Technology
- Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [HI13C1527]
- Kyungpook National University Research Fund
- National Research Foundation of Korea [2013R1A2A2A01005155, 2013R1A1A2058145] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Context: Clinical studies have shown that combined oral contraceptive (COC) use is associated with cardiometabolic disturbances. Elevated renin-angiotensin system (RAS) and plasminogen activator inhibitor-1 (PAI-1) have also been implicated in the development of cardiometabolic events. Objective: To determine the effect of COC treatment on cardiac RAS and PAI-1 gene expressions, and whether the effect is circulating aldosterone or corticosterone dependent. Methods: Female rats were treated (p.o.) with olive oil (vehicle) or COC (1.0 mu g ethinylestradiol and 10.0 mu g norgestrel) daily for six weeks. Results: COC treatment led to increases in blood pressure, HOMA-IR, Ace1 mRNA, Atr1 mRNA, Pai1 mRNA, cardiac PAI-1, plasma PAI-1, C-reactive protein, uric acid, insulin and corticosterone. COC treatment also led to dyslipidemia, decreased glucose tolerance and plasma 17 beta-estradiol. Conclusion: These results demonstrates that hypertension and insulin resistance induced by COC is associated with increased cardiac RAS and PAI-1 gene expression, which is likely to be through corticosterone-dependent but not aldosterone-dependent mechanism.
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