4.7 Article

Untargeted Metabolome Analysis of Alcohol-Exposed Pregnancies Reveals Metabolite Differences That Are Associated with Infant Birth Outcomes

Related references

Note: Only part of the references are listed.
Article Substance Abuse

Evidence for long-lasting alterations in the fecal microbiota following prenatal alcohol exposure

Tamara S. Bodnar et al.

Summary: This study provides the first evidence that prenatal alcohol exposure has a long-lasting and sex-specific impact on the fecal microbiota. This finding is of great significance for the development of new interventions in FASD.

ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH (2022)

Article Endocrinology & Metabolism

Metabolic and Metabo-Clinical Signatures of Type 2 Diabetes, Obesity, Retinopathy, and Dyslipidemia

Noha A. Yousri et al.

Summary: Macro- and microvascular complications of type 2 diabetes, obesity, and dyslipidemia have shared metabolic pathways. This study identified 373 metabolites associated with these conditions, including novel ones such as phospholipids, sphingolipids, and dipeptides. Clustering analysis revealed metabo-clinical signatures that correlated with different clinical patterns, highlighting the importance of specific metabolic pathways. The study also discovered potential associations between certain metabolites and retinopathy, high cholesterol levels, and kidney function.

DIABETES (2022)

Review Nutrition & Dietetics

Effects of nutrition and gestational alcohol consumption on fetal growth and development

Vishal D. Naik et al.

Summary: Fetal alcohol exposure can lead to developmental disorders, and inadequate nutrition can worsen these effects. This review explores the interaction between nutrition and gestational alcohol consumption on fetal growth and development, as well as the potential benefits of micronutrient supplementation.

NUTRITION REVIEWS (2022)

Article Nutrition & Dietetics

Untargeted Metabolome Analysis Reveals Reductions in Maternal Hepatic Glucose and Amino Acid Content That Correlate with Fetal Organ Weights in a Mouse Model of Fetal Alcohol Spectrum Disorders

Nipun Saini et al.

Summary: Prenatal alcohol exposure can cause fetal growth restrictions. Alcohol affects maternal metabolism, limiting glucose availability and resulting in changes in metabolic products, which may impact fetal weight.

NUTRIENTS (2022)

Article Nutrition & Dietetics

Mediating and Moderating Effects of Iron Homeostasis Alterations on Fetal Alcohol-Related Growth and Neurobehavioral Deficits

R. Colin Carter et al.

Summary: This study examined the effects of prenatal alcohol exposure (PAE) on iron homeostasis, growth, and neurobehavior. The results showed that PAE was associated with growth restriction, deficits in visual recognition memory and processing speed, and higher levels of emotionality and shyness. Changes in maternal hemoglobin and ferritin levels appeared to exacerbate these effects. Causal inference analyses also suggested that alterations in maternal ferritin and hemoglobin:log(ferritin) mediated a significant portion of PAE-related growth restriction. These findings highlight the potential role of iron homeostasis alterations in fetal alcohol spectrum disorders (FASD).

NUTRIENTS (2022)

Article Substance Abuse

The prevalence, child characteristics, and maternal risk factors for the continuum of fetal alcohol spectrum disorders: A sixth population-based study in the same South African community

Philip A. May et al.

Summary: The study found that children with fetal alcohol spectrum disorders (FASD) differed significantly from controls in dysmorphology and neurobehavioral aspects. Risk factors for FASD included maternal characteristics, education level, household income, and alcohol consumption during pregnancy. Some risk factors may make women more likely to have children with FASD.

DRUG AND ALCOHOL DEPENDENCE (2021)

Article Multidisciplinary Sciences

An enriched biosignature of gut microbiota-dependent metabolites characterizes maternal plasma in a mouse model of fetal alcohol spectrum disorder

Manjot S. Virdee et al.

Summary: Prenatal alcohol exposure (PAE) leads to permanent cognitive disabilities, while microbial-dependent products (MDPs) generated by the enteric microbiome may be associated with disorders such as autism, depression, and anxiety. Analysis of a mouse model showed that alcohol exposure altered the levels of MDPs in maternal and fetal plasma, potentially influencing pathologies related to PAE.

SCIENTIFIC REPORTS (2021)

Article Endocrinology & Metabolism

Global metabolomic profiling reveals hepatic biosignatures that reflect the unique metabolic needs of late-term mother and fetus

Nipun Saini et al.

Summary: Gestational disorders are characterized by altered metabolic interactions between mother and fetus, with fetal metabolism under distinct and tightly controlled regulation compared to the dam. The metabolite profiles reflect different metabolic needs in the fetus, with contributions to energy demands and growth. The late-term mouse serves as a suitable model for investigating how maternal-fetal metabolism adapts to gestational stressors.

METABOLOMICS (2021)

Article Multidisciplinary Sciences

Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction

Lina Youssef et al.

Summary: Preeclampsia and fetal growth restriction are placenta-mediated disorders, and metabolomics can help understand these conditions. Lipid profiles were altered in affected mothers and fetuses, with low-molecular-weight metabolites extensively disturbed in preeclamptic mothers. Growth restricted fetuses showed similar changes in metabolites to their mothers, while normotensive FGR fetuses had few differences.

SCIENTIFIC REPORTS (2021)

Review Biochemistry & Molecular Biology

The Multiple Roles of Sphingomyelin in Parkinson's Disease

Paola Signorelli et al.

Summary: Recent advances in research have shed light on the role of sphingomyelin in Parkinson's disease, with sphingomyelin being implicated in nerve impulse conduction and neurotransmitter receptor localization, possibly contributing to the development of Parkinson's disease.

BIOMOLECULES (2021)

Review Biochemistry & Molecular Biology

Alcohol effects on hepatic lipid metabolism

Sookyoung Jeon et al.

JOURNAL OF LIPID RESEARCH (2020)

Article Clinical Neurology

Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder

Jeffrey R. Wozniak et al.

JOURNAL OF NEURODEVELOPMENTAL DISORDERS (2020)

Article Biochemistry & Molecular Biology

MetaboAnalystR 3.0: Toward an Optimized Workflow for Global Metabolomics

Zhiqiang Pang et al.

METABOLITES (2020)

Article Biochemistry & Molecular Biology

Blood Metabolomic Profiling Confirms and Identifies Biomarkers of Food Intake

Julia Langenau et al.

METABOLITES (2020)

Article Medicine, General & Internal

Multiomics Characterization of Preterm Birth in Low- and Middle-Income Countries

Fyezah Jehan et al.

JAMA NETWORK OPEN (2020)

Review Biochemistry & Molecular Biology

Maternal iron nutriture as a critical modulator of fetal alcohol spectrum disorder risk in alcohol-exposed pregnancies

Kaylee K. Helfrich et al.

BIOCHEMISTRY AND CELL BIOLOGY (2018)

Article Medicine, General & Internal

Prevalence of Fetal Alcohol Spectrum Disorders in 4 US Communities

Philip A. May et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

Article Cell Biology

Maternal Plasma Metabolomic Profiles in Spontaneous Preterm Birth: Preliminary Results

Barbara Lizewska et al.

MEDIATORS OF INFLAMMATION (2018)

Article Nutrition & Dietetics

Nutritional metabolomics and breast cancer risk in a prospective study

Mary C. Playdon et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2017)

Article Nutrition & Dietetics

Comparing metabolite profiles of habitual diet in serum and urine

Mary C. Playdon et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2016)

Article Reproductive Biology

Maternal nutritional status as a contributing factor for the risk of fetal alcohol spectrum disorders

Philip A. May et al.

REPRODUCTIVE TOXICOLOGY (2016)

Article Obstetrics & Gynecology

Metabolomics and the great obstetrical syndromes - GDM, PET, and IUGR

Angelica Dessi et al.

BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY (2015)

Article Multidisciplinary Sciences

Longitudinal Metabolomic Profiling of Amino Acids and Lipids across Healthy Pregnancy

Karen L. Lindsay et al.

PLOS ONE (2015)

Article Biochemical Research Methods

Pregnancy-Induced Metabolic Phenotype Variations in Maternal Plasma

Hemi Luan et al.

JOURNAL OF PROTEOME RESEARCH (2014)

Review Nutrition & Dietetics

Nutrition Implications for Fetal Alcohol Spectrum Disorder

Jennifer K. Young et al.

ADVANCES IN NUTRITION (2014)

Article Substance Abuse

Approaching the Prevalence of the Full Spectrum of Fetal Alcohol Spectrum Disorders in a South African Population-Based Study

Philip A. May et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2013)

Article Substance Abuse

Global Functional Connectivity Abnormalities in Children with Fetal Alcohol Spectrum Disorders

Jeffrey R. Wozniak et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2013)

Article Public, Environmental & Occupational Health

Associations Between Metabolomic Compounds and Incident Heart Failure Among African Americans: The ARIC Study

Yan Zheng et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2013)

Review Biochemistry & Molecular Biology

Biological functions of sphingomyelins

J. Peter Slotte

PROGRESS IN LIPID RESEARCH (2013)

Article Psychiatry

Alcohol-induced metabolomic differences in humans

M. Jaremek et al.

TRANSLATIONAL PSYCHIATRY (2013)

Article Substance Abuse

Metabolic Biomarkers of Prenatal Alcohol Exposure in Human Embryonic Stem Cell-Derived Neural Lineages

Jessica A. Palmer et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2012)

Article Obstetrics & Gynecology

Metabolomics and first-trimester prediction of early-onset preeclampsia

Ray O. Bahado-Singh et al.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2012)

Review Psychology, Clinical

What Does Diffusion Tensor Imaging Reveal About the Brain and Cognition in Fetal Alcohol Spectrum Disorders?

Jeffrey R. Wozniak et al.

NEUROPSYCHOLOGY REVIEW (2011)

Article Chemistry, Multidisciplinary

Organization of GC/MS and LC/MS metabolomics data into chemical libraries

Corey D DeHaven et al.

Journal of Cheminformatics (2010)

Review Neurosciences

Modulation of glutamatergic transmission by sulfated steroids: Role in fetal alcohol spectrum disorder

C. Fernando Valenzuela et al.

BRAIN RESEARCH REVIEWS (2008)

Review Behavioral Sciences

Metabolic and genetic factors contributing to alcohol induced effects and fetal alcohol syndrome

Simonetta Gemma et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2007)

Review Developmental Biology

Endocrine mechanisms of intrauterine programming

AL Fowden et al.

REPRODUCTION (2004)

Article Nutrition & Dietetics

The effect of maternal smoking and ethanol on fatty acid transport by the human placenta

P Haggarty et al.

BRITISH JOURNAL OF NUTRITION (2002)