Ewing Sarcoma: Rare Metastasis to the Pancreas

Ewing sarcoma is a highly aggressive malignancy of bone or soft tissue, which may present with metastasis for 20%-25% of patients. The most common sites of metastatic lesions are the bone, bone marrow, and lungs. When metastatic lesions present within rare visceral sites, such as the pancreas, it may lead to an incorrect diagnosis of small cell neuroendocrine carcinoma. We report a case of a 37-year-old man with metastatic Ewing sarcoma involving the pancreas, confirmed by imaging, sequencing, fluorescence in situ hybridization, and histology, which was initially mistaken for small cell neuroendocrine carcinoma.

Automated summary

We report a rare case of metastatic Ewing sarcoma involving the pancreas, which was initially misdiagnosed as small cell neuroendocrine carcinoma. This case highlights the challenges in diagnosing metastatic lesions in rare sites.