Journal
TRANSLATIONAL AND CLINICAL PHARMACOLOGY
Volume 30, Issue 4, Pages 172-181Publisher
KSCPT
DOI: 10.12793/tcp.2022.30.e22
Keywords
Machine Learning; Personalized Medicine; Pharmacotherapy; Clinical Decision Rules; Warfarin
Categories
Funding
- National Research Foundation of Korea (NRF) - Korean government (MSIT)
- [2018R1A5A2021242]
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This article introduces personalized drug dosing prediction models, including the conventional multiple linear regression model and machine learning models such as random forest and neural network models. Through model training and analysis on the dataset, functions such as performance comparison, permutation feature importance computation, and partial dependence plotting can be achieved. These methods are of great significance to drug dose-related studies.
For personalized drug dosing, prediction models may be utilized to overcome the inter -individual variability. Multiple linear regression has been used as a conventional method to model the relationship between patient features and optimal drug dose. However, linear regression cannot capture non-linear relationships and may be adversely affected by non -normal distribution and collinearity of data. To overcome this hurdle, machine learning models have been extensively adapted in drug dose prediction. In this tutorial, random forest and neural network models will be trained in tandem with a multiple linear regression model on the International Warfarin Pharmacogenetics Consortium dataset using the scikit-learn python library. Subsequent model analyses including performance comparison, permutation feature importance computation and partial dependence plotting will be demonstrated. The basic methods of model training and analysis discussed in this article may be implemented in drug dose-related studies.
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