Transition Metal-Catalyzed Asymmetric Cyclizations Involving Allyl or Propargyl Heteroatom-Dipole Precursors

Chiral heterocyclic compounds are an important class of chiral substances, which are widespread in many chiral drugs, pesticides and catalysts. Therefore, the efficient asymmetric synthesis of these compounds becomes a research hotspot in organic synthesis. Transition metal-catalyzed asymmetric cyclization with heteroatom-dipole precursors is an important method to construct these frameworks. Among them, the heteroatom-dipole precursors designed based on transition metal-catalyzed allyl or propargyl substitutions have been extensively studied in the past two decades and occupied an important role in this field. The transition metal-catalyzed asymmetric cyclizations with allyl or propargyl heteroatom-dipole precursors are introduced in detail. The advantages and existing problems of the current methods are analyzed, which would provide useful reference for the researchers in asymmetric synthesis and related fields.

Automated summary

The article introduces the asymmetric synthesis of chiral heterocyclic compounds using transition metal-catalyzed cyclization, focusing on the application and issues of allyl or propargyl heteroatom-dipole precursors.