Journal
CHINESE JOURNAL OF ORGANIC CHEMISTRY
Volume 42, Issue 10, Pages 3373-3381Publisher
SCIENCE PRESS
DOI: 10.6023/cjoc202209002
Keywords
palladium catalysis; phosphine-alkene ligand; indole; allylic alkylation; asymmetric catalysis
Categories
Funding
- National Natural Science Foundation of China [21871213, 22071189]
- Fundamental Research Funds for Central Universities [2042021kf0214]
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A new type of axially chiral phosphine-alkene ligands have been developed for Pd-catalyzed asymmetric allylic alkylation of indoles via a two-step modular synthesis. The reaction provides a series of chiral allylindole products with generally high yields (up to 95%) and excellent enantioselectivities (up to 96% ee).
A new type of axially chiral phosphine-alkene ligands have been developed via a two-step modular synthesis for Pd-catalyzed asymmetric allylic alkylation of indoles. Under optimized reaction conditions, a series of chiral allylindole products were obtained in generally high yields (up to 95%) and excellent enantioselectivities (up to 96% ee).
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