Recent Progress on the Synthesis of Benzazepine Derivatives via Radical Cascade Cyclization Reactions

Benzazepines are a kind of important seven-membered nitrogen-containing heterocyclic compounds, which are extensively exisited in natural products and pharmaceuticals, and have versatile biological activity. Therefore, great attention has been focused on the green and efficient synthesis of the benzazepines. In recent years, radical cascade cyclization reactions have gradually been developed as a powerful tool for the construction of benzazepines owing to their unique advantages. In this minireview, according to the different driving force of reaction, the research progress on the synthesis of benzazepines by radical cascade cyclization reactions in the past five years is systematically summarized in terms of photochemical reactions, electrochemical reactions and thermochemical reactions.

Automated summary

Benzazepines, important nitrogen-containing heterocyclic compounds, are widely found in natural products and pharmaceuticals and possess versatile biological activity. The green and efficient synthesis of benzazepines has attracted great attention. Radical cascade cyclization reactions have emerged as a powerful tool for constructing benzazepines due to their unique advantages. This minireview systematically summarizes the research progress on the synthesis of benzazepines via radical cascade cyclization reactions in the past five years, including photochemical, electrochemical, and thermochemical reactions.