Journal
PANCREAS
Volume 51, Issue 8, Pages 985-994Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MPA.0000000000002143
Keywords
pancreatic cancer; oral hygiene; periodontal disease; meta-analysis
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Funding
- characteristic technology item of major clinical innovation of the Second Affiliated Hospital of Army Medical University [2018jslc0022]
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The relationship between oral disease and pancreatic cancer (PC) is investigated in this systematic review and meta-analysis. Epidemiological studies have shown inconsistent results on the association of poor oral hygiene, periodontal disease, and tooth loss with the risk of PC. Therefore, this study aims to provide a comprehensive analysis of existing literature on this topic.
ObjectivesEpidemiological studies have reported the association of poor oral hygiene, especially periodontal disease, and tooth loss with the risk of pancreatic cancer (PC). However, these studies have yielded inconsistent results. Therefore, this systematic review and meta-analysis aimed to investigate the relationship between oral disease and PC.MethodsWe systematically searched the PubMed, Embase, and Cochrane Library databases for English literature since inception through May 2021. We used relative risks, hazard ratios, or odds ratios to measure the association between oral disease and PC. A fixed- or random-effects model was applied to evaluate pooled risk estimates, and sensitivity and subgroup analyses were performed to identify sources of heterogeneity and pooled estimation.ResultsWe identified 17 relevant observational studies involving 1,352,256 participants. Notably, oral disease correlated significantly with PC (hazard ratio [HR], 1.32; 95% confidence interval [CI], 1.13-1.54). In subgroup analyses, subjects with periodontal disease (HR, 1.38; 95% CI, 1.12-1.71) had a higher risk of developing PC than those with tooth loss (HR, 1.19; 95% CI, 0.97-1.46).ConclusionsThe results suggest that subjects with oral disease may face a significant and independent risk of PC. However, the mechanisms linking oral disease and PC are uncertain, and additional investigations of this correlation are warranted.
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