Journal
ADVANCED MATERIALS INTERFACES
Volume 3, Issue 18, Pages -Publisher
WILEY-BLACKWELL
DOI: 10.1002/admi.201600472
Keywords
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Funding
- National Natural Science Foundation of China [21574091, 21446005, 21204056, 21576120]
- Natural Science Foundation of Jiangsu Province [BK20131223, BK20160056, BK20160491, BK2012173]
- Special National Postdoctoral Science Foundation [2014T70480, 2015M580398]
- Postdoctoral Science Foundation of Jiangsu Province [1202002B, 1501027B]
- Programs of Senior Talent Foundation of Jiangsu University [12JDG090]
- Jiangsu Provincial Special Program of Medical Science [BL2012004]
- Jiangsu Provincial Clinical Orthopedic Center
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Jane and Aatos Erkko Foundation [4704010]
- Academy of Finland [252215, 281300]
- University of Helsinki
- Biocentrum Helsinki
- European Research Council under the European Union's Seventh Framework Programme (FP) [310892]
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Zinc-doped copper oxide (Zn-CuO) is a promising material for the development of antimicrobial materials due to its safety and the highly effective antibacterial activities against multidrug-resistant bacteria. As known, the intracellular reactive oxygen species produced by Zn-CuO nanomaterials play important role in bacterial killing; however, the relationship between their nanostructure and antibacterial activity has yet to be elucidated. In this study, we prepare, for the first time, Zn-CuO nanoparticles with prickly nanostructures via a green sonochemical method. The resultant prickly Zn-CuO nanoparticles exhibit strong antibacterial activity that can kill 99.0% of bacteria within 10 min under dark conditions and significantly hamper bacterial growth in Luria-Bertani culture medium. It is also found that prickly Zn-CuO nanoparticles show a nanopiercing process on bacterial membrane and subsequently lead to accelerated cytoplasma leakage. To further check the effect of nanopiercing on membrane damage and bacterial killing, Zn-CuO nanorods are employed with two sharp tips for comparison. Due to the great change of nanopiercing process from multidimension (prickly) to 1D (rod-like), the Zn-CuO nanorods exhibit distinctly lower antibacterial activity compared with prickly Zn-CuO nanoparticles. This finding definitely indicates the importance of nanostructures on the antibacterial activity of Zn-CuO nanoparticles, i.e., architecture-enhanced nanopiercing for bacterial killing.
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