Journal
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
Volume 94, Issue -, Pages -Publisher
ACAD BRASILEIRA DE CIENCIAS
DOI: 10.1590/0001-3765202220220717
Keywords
hyperglycemia; offspring; preimplantation; pregnancy; rodents
Categories
Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) - Brazil for Vinicius S. Barco's fellowship
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) - Brazil [2016/25207-5]
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Pregestational hyperglycemia has adverse effects on mothers and their offspring. A study on diabetic rats found that diabetic mothers and their descendants exhibited glucose intolerance, and early embryos showed delayed development, degeneration, and losses.
Pregestational hyperglycemia cause adverse effects on mothers and their offspring. We aimed to evaluate the maternal hyperglycemia influence on pre-embryos from diabetic rats and on their generations (daughters and granddaughters). Diabetes was induced in Sprague-Dawley rats. The mothers and their female pups were submitted to oral glucose tolerance test in adulthood. In day 4 of pregnancy, pre-embryos were collected for morphological analysis. The diabetic mother, daughter and granddaughter rats showed glucose intolerance and their pre-embryos presented developmental delay, degeneration and losses compared to the nondiabetic group. Thus, maternal diabetes transgenerationally affects embryos at early development, which contributes for embryofetal losses.
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