4.6 Article

Chronic viral hepatitis accelerates lung function decline in smokers

Journal

CLINICAL AND EXPERIMENTAL MEDICINE
Volume -, Issue -, Pages -

Publisher

SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10238-022-00963-5

Keywords

Chronic hepatitis B; Chronic hepatitis C; Forced expiratory volume; Respiratory function tests; Smoking; Trajectory

Ask authors/readers for more resources

This study found an association between chronic viral hepatitis infection and decreased lung function, specifically in smokers. Non-invasive measurement of hepatic fibrosis may be useful in predicting rapid lung function decline in smokers with chronic viral hepatitis.
Although hepatitis B virus (HBV) and hepatitis C virus (HCV) are hepatotrophic viruses, they may affect pulmonary diseases. The purpose of this study was to assess whether chronic viral hepatitis (CVH) infection was associated with a rapid decline in lung function. Repeated measurements of lung function were obtained from a well-curated health check-up database. A case was defined as an individual positive for HBsAg or anti-HCV antibody. A control was randomly selected (from the same dataset) after 1:1 matching in terms of age, sex, height, the body mass index, and smoking status. Separate analyses of non-smokers and smokers were performed. A total of 701 cases were enrolled (586 with HBV and 115 with HCV). In cross-sectional analysis, both forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) decreased significantly only in smokers (smoking cases vs. smoking controls) (adjusted p = 6.6 x 10(-5) and adjusted p = 2.2 x 10(-3), respectively). In longitudinal analysis, smoking cases showed significantly greater FEV1 and FVC decline rates than did smoking controls (adjusted p = 8.5 x 10(-3) and adjusted p = 1.2 x 10(-5), respectively). Such associations were particularly high in smoking cases at intermediate-to-high risk of hepatic fibrosis, as evaluated by the non-invasive Fibrosis-4 index. In summary, CVH was associated with both decreased lung function and accelerated lung function decline in smokers. A non-invasive measurement of hepatic fibrosis may be useful in predicting rapid lung function decline in smokers with CVH.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available