4.2 Article

A behavioral paradigm for measuring perceptual distances in mice

Journal

CELL REPORTS METHODS
Volume 2, Issue 6, Pages -

Publisher

CELL PRESS
DOI: 10.1016/j.crmeth.2022.100233

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Funding

  1. NIH BRAIN Initiative [U19NS112953]

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The article introduces a behavioral paradigm that quantifies perceptual similarity between sensory stimuli using mouse olfaction as a model system. This is crucial for understanding neural computations responsible for sensory representations.
Perceptual similarities between a specific stimulus and other stimuli of the same modality provide valuable information about the structure and geometry of sensory spaces. While typically assessed in human behavioral experiments, perceptual similarities-or distances-are rarely measured in other species. However, understanding the neural computations responsible for sensory representations requires the monitoring and often manipulation of neural activity, which is more readily achieved in non-human experimental models. Here, we develop a behavioral paradigmthat enables the quantification of perceptual similarity between sensory stimuli using mouse olfaction as a model system.

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