Journal
CANADIAN JOURNAL OF ANIMAL SCIENCE
Volume 102, Issue 4, Pages 561-570Publisher
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/CJAS-2021-0112561
Keywords
Jiangnan cashmere goat; Tibetan cashmere goat; cashmere fiber diameter; KRTAPs
Categories
Funding
- Special Funds for Basic Scientific Research Operation of Public Welfare Scientific Research Institutes in Xinjiang Autonomous Region
- Xinjiang Autonomous Region Innovation Environment Construction Special Project [2020Q035, 2021D04008]
- Agriculture Research System of China [CARS-39]
- Innovation Project of Shandong Academy of Agricultural Sciences [13200214443101]
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This study identified the polymorphisms of KRTAP genes in Jiangnan and Tibetan cashmere goats and found their correlation with fiber diameter. A total of 28 mutation sites were identified, providing valuable information for improving fiber diameter and preserving germplasm resources of cashmere goats.
Fiber diameter, a quantitative trait, is controlled by minor effect polygenes. Keratin-associated proteins (KRTAPs) are an important part of hair, and their rich polymorphisms facilitate the mining of cashmere trait molecular markers. In this study, Jiangnan and Tibetan cashmere goats were taken as the research object; multiplex PCR and exome sequencing technology were used to identify the exon regional polymorphisms of cashmere goats KRTAP15-1, KRTAP13.1, KRTAP27-1, and KRTAP24-1. The effects of mutation sites on the fiber diameter of cashmere were analyzed by least square method. The results showed that there were 28 mutation sites in the four KRTAP genes in Jiangnan cashmere goats and Tibetan cashmere goat populations. Among them, the KRTAP13.1, KRTAP27-1, and KRTAP24-1 gene polymorphisms were found to be significantly related to the fiber diameter of Jiangnan cashmere goats. The exploration of molecular markers in this study will help to improve the fiber diameter of the down, while the identification of gene polymorphisms will provide original data for the utilization and protection of germplasm resources of cashmere goats.
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