Divergent Synthesis of 2-Cyanoaryl Carbamate and 2-Cyanoaryl Urea Derivatives via Hypervalent Iodine-Induced C-C Bond Cleavage

Divergent synthetic methods for transforming isatins to 2-cyanoaryl carbamate and 2-cyanoaryl urea derivatives were developed using ammonium carbamate as the nitrogen source and iodobenzene diacetate as the oxidant. This reaction features mild conditions, broad substrate scope, and moreover, the use of toxic cyano-containing compounds is avoided.

Automated summary

Divergent synthetic methods for converting isatins to 2-cyanoaryl carbamate and 2-cyanoaryl urea derivatives were developed, utilizing ammonium carbamate as the nitrogen source and iodobenzene diacetate as the oxidant. This reaction offers mild conditions, a wide range of substrate adaptability, and avoids the use of toxic cyano-containing compounds.