Aptamers for Viral Detection and Inhibition

Recent times have experienced more than ever the impact of viral infections in humans. Viral infections are known to cause diseases not only in humans but also in plants and animals. Here, we have compiled the literature review of aptamers selected and used for detection and inhibition of viral infections in all three categories: humans, animals, and plants. This review gives an in-depth introduction to aptamers, different types of aptamer selection(SELEX) methodologies, the benefits of using aptamers over commonly used antibody-basedstrategies, and the structural and functional mechanism of aptasensors for viral detection andtherapy. The review is organized based on the different characterization and read-out toolsused to detect virus-aptasensor interactions with a detailed index of existing virus-targetingaptamers. Along with addressing recent developments, we also discuss a way forward with aptamers for DNA nanotechnology-based detection and treatment of viral diseases. Overall, this review will serve as a comprehensive resource for aptamer-based strategies in viral diagnostics and treatment.

Automated summary

This review compiles literature on the use of aptamers for detection and inhibition of viral infections in humans, animals, and plants. It provides an in-depth introduction to aptamers, their selection methodologies, advantages over antibody-based strategies, and the mechanisms of aptasensors for viral detection and therapy. The review also discusses future directions in aptamer-based strategies for viral diagnostics and treatment, making it a comprehensive resource in this field.