POLYMORPHISM RS1127327 OF THE MICRORNA-146A TARGET GENE CCDC6 ASSOCIATED WITH A REDUCED RISK OF SEVERE HEMORRHAGIC FEVER WITH RENAL SYNDROME IN PATIENTS FROM THE VOLGA-URAL REGION OF RUSSIA

The association analysis of polymorphic variants common for miRNA-146a, miRNA-218, miRNA-410, miRNA-503 target genes was performed in patients with hemorrhagic fever infected with PUUV. It has been revealed that the genotype rs1127327*AA of the CCDC6 gene is associated with a reduced risk of severe disease form. Further studies of the network of genes that are targets of various miRNAs are needed to elucidate the molecular mechanisms that can influence the onset and development of HFRS.

Automated summary

The association between polymorphic variants of miRNA-146a, miRNA-218, miRNA-410, miRNA-503 target genes and hemorrhagic fever caused by PUUV infection was studied. The genotype rs1127327*AA of the CCDC6 gene was found to be associated with a reduced risk of severe disease. Further investigation is needed to understand the molecular mechanisms underlying the effect of miRNA target genes on the onset and progression of HFRS.