Journal
NEURAL REGENERATION RESEARCH
Volume 17, Issue 11, Pages -Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
Keywords
brain aging; cognitive decline; dysbiosis; fecal microbiota transplantation; gut-microbiota; neuroinflammation; prebiotics; probiotics
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Funding
- College of Pharmacy, Department of Pharmaceutical Chemistry, King Saud University, Riyadh, Saudi Arabia
- American Heart Association [17AIREA33700076/ZAS/2017]
- National Institute of Neurological Disorders and Stroke of the National Institutes of Health [R01NS112642]
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Recent research on intestinal microbiota has shown its significant contribution to the central nervous system during health and disease. Age-related changes in intestinal microbiota can lead to brain aging and neurodegenerative disorders, making maintaining a healthy gut microbiota crucial for a healthy body and aging.
Recent emerging research on intestinal microbiota and its contribution to the central nervous system during health and disease has attracted significant attention. Age-related intestinal microbiota changes initiate brain aging and age-related neurodegenerative disorders. Aging is one of the critical predisposing risk factors for the development of neurodegenerative diseases. Maintaining a healthy gut microbiota is essential for a healthy body and aging, but dysbiosis could initiate many chronic diseases. Understanding the underlying mechanisms of gut microbiota alterations/dysbiosis will help identify biomarkers for aging-related chronic conditions. This review summarizes recent advances in microbiota-neurodegenerative disease research and will enhance our understanding of gut microbiota dysbiosis and its effects on brain aging.
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