Space-time-regulated imaging analyzer for smart coagulation diagnosis

The development of intelligent blood coagulation diagnoses is awaited to meet the current need for large clinical time-sensitive caseloads due to its efficient and automated diagnoses. Herein, a method is reported and validated to realize it through artificial intelligence (AI)-assisted optical clotting biophysics (OCB) properties identification. The image differential calculation is used for precise acquisition of OCB properties with elimination of initial differences, and the strategy of space-time regulation allows on-demand space time OCB properties identification and enables diverse blood function diagnoses. The integrated applications of smartphones and cloud computing offer a user-friendly automated analysis for accurate and convenient diagnoses. The prospective assays of clinical cases (n = 41) show that the system realizes 97.6%, 95.1%, and 100% accuracy for coagulation factors, fibrinogen function, and comprehensive blood coagulation diagnoses, respectively. This method should enable more low-cost and convenient diagnoses and provide a path for potential diagnostic-markers finding.

Automated summary

An intelligent blood coagulation diagnosis method based on AI-assisted optical clotting biophysics (OCB) properties identification is reported. This method utilizes image differential calculation and space-time regulation strategy to achieve diverse blood function diagnoses. The integrated applications of smartphones and cloud computing offer a user-friendly automated analysis. Clinical experiments demonstrate high accuracy.