Related references
Note: Only part of the references are listed.
Review
Pharmacology & Pharmacy
Kainan Song et al.
Summary: Plant-derived flavonolignans have been shown to have various biological functions. This review identifies 88 constituents from natural resources and summarizes the various derivatives of flavonolignans, as well as their pharmacological effects such as anti-tumour, antioxidant, anti-microorganic, and anti-inflammatory effects. The review also highlights the potential commercialization of flavonolignans which could uplift the financial abilities of communities and make it an international herbal and pharmaceutical commodity.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Plant Sciences
Ping Qiu et al.
Summary: Inoscavin A, derived from the Sanghuangporus vaninii extract, exhibits anti-tumor activity in an HT-29 colon cancer cell xenograft mouse model. Its anti-tumor effects are related to the hedgehog (Hh) signaling pathway, with Smo being the core receptor and critical for inducing apoptosis.
Article
Oncology
Jun Ki Hong et al.
Summary: The study reveals the potential of CJ14939 in inducing colorectal cancer cell death and inhibiting phosphorylation of JAK1 and STAT3. Furthermore, combination therapy with CJ14939 and oxaliplatin significantly reduces tumor growth, suggesting a novel therapeutic strategy for patients with colorectal cancer.
ANTICANCER RESEARCH
(2022)
Article
Oncology
Min Kyoung Jo et al.
Summary: This study demonstrates that low-dose alpha M selectively inhibits CRC CSCs and suppresses the 5-FU-induced augmentation of CSCs through the Notch signaling pathway.
Article
Cell Biology
Wei Yang et al.
Summary: TOX3 is found to be overexpressed in colorectal cancer (CRC), and its expression is associated with aggressive features and prognosis of CRC patients. TOX3 promotes CRC cell proliferation, inhibits apoptosis, and decreases sensitivity to oxaliplatin. The TOX3/MAPK/RhoB signaling pathway plays a crucial role in the regulation of proliferation and apoptosis of CRC cells.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Chemistry, Medicinal
Jing Hong et al.
Summary: The target protein of erianin in human cells was identified as pyruvate carboxylase, and the anti-tumor signaling pathway regulated by erianin was explored in various cell lines. Erianin specifically inhibits the activity of pyruvate carboxylase and selectively inhibits the activity of pyruvate carboxylase. Erianin can also regulate the pyruvate carboxylase-mediated Wnt/ β-Catenin pathway.
Article
Plant Sciences
Gamal A. Mohamed et al.
Summary: This study investigated the hepatoprotective effect of cucurbitacin E glucoside (CuE) against Con A-induced hepatitis. The results demonstrated that CuE could effectively attenuate liver damage, suppress oxidative stress, and inhibit inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shen Guan et al.
Summary: The expression of CD133 and CXCR4 was higher in metastatic liver cancer tissues compared to primary tumor and paratumor tissues. CD133(+)CXCR4(+) cells play a crucial role in the development and progression of colon cancer, inducing significant phosphorylation of PI3K/AKT.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Andreea-Adriana Neamtu et al.
Summary: Colorectal cancer is the third most common cancer worldwide, with most cases being sporadic and caused by diet and environmental factors. Quercetin, a polyphenolic flavonoid plant secondary metabolite with antioxidant activity, has been extensively studied as an anti-carcinogenic agent in scientific literature. Research has identified molecular targets of quercetin in colorectal cancer models and its modulation of various signaling pathways.
Article
Plant Sciences
Xiao-Xin Chen et al.
Summary: We found that granatin B and punicalagin from pomegranate peels have superior anti-colorectal cancer and anti-mucositis activities. These phenols target reactive oxygen species and induce S-phase cell cycle arrest and apoptosis in colorectal cancer cells. They also enhance the efficacy of 5-FU-induced cell death and S-phase cell cycle arrest. These results suggest that using granatin B and punicalagin as therapeutic agents may be an innovative approach to treat colorectal cancer and intestinal mucositis.
Article
Chemistry, Medicinal
Ziyuan Wang et al.
Article
Oncology
Najjia N. Mahmoud
Summary: Colorectal tumor staging has undergone some changes over time, but not significantly. In the past 10 years, advancements in our understanding of tumor genetics and the use of MRI technology for rectal cancer staging have altered the way we assess colon and rectal cancers. Currently, CT scanning, a thorough history and physical examination, and colonoscopic assessment are still the mainstays of staging. Successful staging of colorectal cancer requires coordination and cooperation between surgery, gastroenterology, medical oncology, pathology, and radiology.
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA
(2022)
Article
Oncology
Xiaochun Qin et al.
Summary: The study found that ZDQ-0620 inhibits the proliferation, migration, and invasion of CRC cells by targeting the PI3K/AKT pathway. It induces apoptosis in CRC cells by causing cell cycle arrest and activating the mitochondrial pathway. Additionally, ZDQ-0620 inhibits angiogenesis. These findings suggest that ZDQ-0620 has potential as an effective treatment candidate against CRC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Xuyang Lv et al.
Article
Biochemistry & Molecular Biology
Yuanyuan Wu et al.
Summary: Acteoside can inhibit melanoma growth, alleviate inflammation levels in mice, and regulate ROS and apoptosis levels in the spleen. By regulating the ERA-Ras/Raf1-STAT3 signaling axis, acteoside promotes tumor cell apoptosis, thus inhibiting the occurrence and development of melanoma.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Oncology
Hyuna Sung et al.
Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Article
Chemistry, Medicinal
Juan Wang et al.
Summary: Curcumol induces autophagy through the AMPK/mTOR pathway in NPC cells, and inhibiting autophagy can increase proliferation while attenuating apoptosis and autophagy. Combining curcumol with the autophagy agonist rapamycin and apoptosis inducer MG132 synergizes the apoptotic and autophagic effect of curcumol, suggesting a potential new therapeutic strategy for NPC.
PHYTOTHERAPY RESEARCH
(2021)
Review
Oncology
Said M. Afify et al.
Summary: The PI3K/AKT/mTOR pathway is a crucial regulator of cell proliferation and survival, with dysregulation leading to cancer development. Many drugs targeting this pathway are in clinical trials, but further understanding of the signaling mechanism is necessary for better therapeutic efficacy.
EXPERT REVIEW OF ANTICANCER THERAPY
(2021)
Article
Medicine, Research & Experimental
Danjun Chen et al.
Summary: Salidroside, an active ingredient of Rhodiola rosea, shows antitumor effects in chronic myeloid leukemia (CML) by inhibiting cell proliferation and promoting apoptosis through regulation of miR-140-5p and suppression of the wnt5a/beta-catenin signaling pathway.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Bryson W. Katona et al.
Review
Biochemistry & Molecular Biology
Luca Braglia et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2020)
Article
Oncology
Kortnye Maureen Smith et al.
EXPERT REVIEW OF ANTICANCER THERAPY
(2018)
Review
Gastroenterology & Hepatology
Kevin Van der Jeught et al.
WORLD JOURNAL OF GASTROENTEROLOGY
(2018)
Article
Chemistry, Medicinal
Stefania Nobili et al.
FUTURE MEDICINAL CHEMISTRY
(2015)
Article
Neurosciences
Jing Ding et al.
