Journal
ACS CHEMICAL BIOLOGY
Volume 17, Issue 12, Pages 3255-3269Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acschembio.1c005183255
Keywords
Photocage; Photoswitch; Photoactivation; Photosensitizer; Singlet oxygen; Drug delivery; Far-red; Near-infrared
Categories
Funding
- NIGMS [5R01GM135380]
- NSF [CHE- 1905242]
- Alfred P. Sloan Foundation [FG-2018-10855]
- NIBIB [5R01EB027172]
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This Review highlights recent developments in synthetic far-red and near-infrared photocages and photoswitches and their current and potential applications at the interface of chemistry and biology.
The complex network of naturally occurring biological pathways motivates the development of new synthetic molecules to perturb and/or detect these processes for fundamental research and clinical applications. In this context, photochemical tools have emerged as an approach to control the activity of drug or probe molecules at high temporal and spatial resolutions. Traditional photochemical tools, particularly photo -labile protecting groups (photocages) and photoswitches, rely on high-energy UV light that is only applicable to cells or transparent model animals. More recently, such designs have evolved into the visible and near-infrared regions with deeper tissue penetration, enabling photocontrol to study biology in tissue and model animal contexts. This Review highlights recent developments in synthetic far-red and near-infrared photocages and photoswitches and their current and potential applications at the interface of chemistry and biology.
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