4.6 Article

PfSPZ-CVac malaria vaccine demonstrates safety among malaria-experienced adults: A randomized, controlled phase 1 trial

Related references

Note: Only part of the references are listed.
Article Infectious Diseases

Safety and efficacy of a three-dose regimen of Plasmodium falciparum sporozoite vaccine in adults during an intense malaria transmission season in Mali: a randomised, controlled phase 1 trial

Mahamadou S. Sissoko et al.

Summary: A clinical trial was conducted in Mali to evaluate the safety, immunogenicity, and protective efficacy of the PfSPZ Vaccine in preventing malaria infection. The study found that the three-dose regimen of the vaccine was safe, well tolerated, and conferred 51% vaccine efficacy against natural P falciparum transmission.

LANCET INFECTIOUS DISEASES (2022)

Article Multidisciplinary Sciences

Plasmodium falciparum 7G8 challenge provides conservative prediction of efficacy of PfNF54-based PfSPZ Vaccine in Africa

Joana C. Silva et al.

Summary: The study shows that controlled human malaria infection with a Brazilian parasite highly divergent from vaccine and West African field strains can provide estimates of vaccine efficacy in Mali, and could replace field testing, streamlining vaccine development.

NATURE COMMUNICATIONS (2022)

Article Multidisciplinary Sciences

Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial

Zita Sulyok et al.

Summary: The study reports the results of a trial on a simplified PfSPZ-CVac immunization regimen, demonstrating its high efficacy, safety, good tolerability, and high immunogenicity in malaria-naive participants.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity

Agnes Mwakingwe-Omari et al.

Summary: Increased vaccine efficacy against malaria can be achieved through higher vaccine dosage and specific chemoprophylaxis vaccination regimens, providing protection against both homologous and heterologous parasite strains. This enhanced protection is associated with V delta 2 gamma delta T cell and antibody responses.

NATURE (2021)

Article Biochemistry & Molecular Biology

Safety, immunogenicity and efficacy of PfSPZ Vaccine against malaria in infants in western Kenya: a double-blind, randomized, placebo-controlled phase 2 trial

Martina Oneko et al.

Summary: A trial of Plasmodium falciparum vaccine in infants in a high-transmission malaria setting in western Kenya showed good safety and tolerability, but no significant protection against P. falciparum infection at 6 months. There was a dose-dependent increase in antibody responses, while T cell responses were undetectable in all dose groups.

NATURE MEDICINE (2021)

Article Microbiology

PfSPZ-CVac efficacy against malaria increases from 0% to 75% when administered in the absence of erythrocyte stage parasitemia: A randomized, placebo-controlled trial with controlled human malaria infection

Sean C. Murphy et al.

Summary: The study evaluated different dosing schedules of PfSPZ-CVac vaccine and found that a higher dose given with a shorter interval achieved better vaccine efficacy, while administering the vaccine during blood-stage parasitemia resulted in almost no efficacy. This suggests that blood-stage infections may impair the protective responses to malaria.

PLOS PATHOGENS (2021)

Article Public, Environmental & Occupational Health

Safety, Immunogenicity, and Protective Efficacy against Controlled Human Malaria Infection of Plasmodium falciparum Sporozoite Vaccine in Tanzanian Adults

Said A. Jongo et al.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2018)

Article Multidisciplinary Sciences

Sterile protection against human malaria by chemoattenuated PfSPZ vaccine

Benjamin Mordmueller et al.

NATURE (2017)

Article Immunology

Vaccines Against Malaria

Amed Ouattara et al.

CLINICAL INFECTIOUS DISEASES (2015)

Article Multidisciplinary Sciences

Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8+ T Cell Immunity

J. E. Epstein et al.

SCIENCE (2011)

Review Microbiology

Acquired Immunity to Malaria

Denise L. Doolan et al.

CLINICAL MICROBIOLOGY REVIEWS (2009)

Article Medicine, General & Internal

Protection against a Malaria Challenge by Sporozoite Inoculation.

Meta Roestenberg et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Immunology

Malaria blood stage suppression of liver stage immunity by dendritic cells

C Ocaña-Morgner et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2003)