Journal
KIDNEY RESEARCH AND CLINICAL PRACTICE
Volume 41, Issue -, Pages S89-S98Publisher
KOREAN SOC NEPHROLOGY
DOI: 10.23876/j.krcp.21.269
Keywords
Diabetic nephropathies; Nox inhibitor; NADPH oxidases; Oxidative stress; Reactive oxygen species
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Funding
- National Research Foundation of Korea (NRF) [2017M3A9D8062955, 2018M3A9G1075771]
- Ministry of Science and ICT
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health amp
- Welfare [HI21C0293]
- National Research Foundation of Korea [2018M3A9G1075771, 2017M3A9D8062955] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Oxidative stress can lead to the generation of uncontrolled reactive oxygen species (ROS), causing damage to cells and tissues. While excessive levels of ROS are harmful, moderate levels are essential for normal physiological function. This review discusses the use of Nox inhibitors as a way to regulate ROS levels and provide therapeutic opportunities for diabetic nephropathy.
Oxidative stress can cause generation of uncontrolled reactive oxygen species (ROS) and lead to cytotoxic damage to cells and tis-sues. Recently, it has been shown that transient ROS generation can serve as a secondary messenger in receptor-mediated cell sig-naling. Although excessive levels of ROS are harmful, moderated levels of ROS are essential for normal physiological function. There-fore, regulating cellular ROS levels should be an important concept for development of novel therapeutics for treating diseases. The overexpression and hyperactivation of NADPH oxidase (Nox) can induce high levels of ROS, which are strongly associated with diabet-ic nephropathy. This review discusses the theoretical basis for development of the Nox inhibitor as a regulator of ROS homeostasis to provide emerging therapeutic opportunities for diabetic nephropathy.
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