4.1 Review

Synthesis and biological activity of potential antiviral compounds through 1,3-dipolar cycloadditions. Part 2: nitrones, nitrile oxides and imines, and other 1,3-dipoles

Journal

ARKIVOC
Volume -, Issue -, Pages 257-294

Publisher

ARKAT USA INC
DOI: 10.24820/ark.5550190.p011.896

Keywords

Antivirals; 1; 3-dipolar cycloadditions; nitrones; nitrile oxides; nitrile imines; nitrosocarbonyls; azomethine ylides; diazoalkanes; synthesis; biological evaluation; nucleosides

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This review discusses the application of 1,3-dipolar cycloadditions in the design and synthesis of antiviral compounds, focusing on the use of nitrones and nitrile oxides. The products obtained from these reactions showed promising antiviral activities through blocking virus replication.
Prominent in the current stage of drug development, antiviral compounds can be efficiently prepared through cycloaddition reactions. This review reports the use of 1,3-dipolar cycloadditions of nitrones, nitrile oxides and imines and other 1,3-dipoles in the light of their application for the preparation of synthons in the design and synthesis of compounds that were tested for their antiviral activities against a variety of viruses. Since nitrile oxides represent valuable precursors of nitrosocarbonyl intermediates, their use in the synthesis of antiviral compounds is reported. The products obtained from these pericyclic reaction approaches were tested for their activities in terms of blocking the virus replication and the relevant biological data are highlighted.

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