4.5 Article

Secretome of Olfactory Mucosa Mesenchymal Stem Cell, a Multiple Potential Stem Cell

Journal

STEM CELLS INTERNATIONAL
Volume 2016, Issue -, Pages -

Publisher

HINDAWI LTD
DOI: 10.1155/2016/1243659

Keywords

-

Funding

  1. National Natural Science Foundation of China [31370817, 81070353, 81371358]
  2. Hunan Provincial Natural Science Foundation of China [14JJ2060]
  3. Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province [20134486]
  4. Scientific Research Fund of Hunan Provincial Education Department [12C0238]
  5. Hunan Provincial Innovation Foundation for Postgraduate [CX2014B237, CX2015B188]

Ask authors/readers for more resources

Nasal olfactory mucosa mesenchymal stem cells (OM-MSCs) have the ability to promote regeneration in the nervous system in vivo. Moreover, with view to the potential for clinical application, OM-MSCs have the advantage of being easily accessible from patients and transplantable in an autologous manner, thus eliminating immune rejection and contentious ethical issues. So far, most studies have been focused on the role of OM-MSCs in central nervous system replacement. However, the secreted proteomics of OM-MSCs have not been reported yet. Here, proteins secreted by OM-MSCs cultured in serum-free conditions were separated on SDS-PAGE and identified by LC-MS/MS. As a result, a total of 274 secreted proteins were identified. These molecules are known to be important in neurotrophy, angiogenesis, cell growth, differentiation, and apoptosis, and inflammation which were highly correlated with the repair of central nervous system. The proteomic profiling of the OM-MSCs secretome might provide new insights into their nature in the neural recovery. However, proteomic analysis for clinical biomarkers of OM-MSCs needs to be further studied.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available