Journal
STEM CELL REVIEWS AND REPORTS
Volume 12, Issue 3, Pages 276-284Publisher
SPRINGER
DOI: 10.1007/s12015-016-9648-6
Keywords
Maternal effect; Regulative development; Determinative development; Embryonic lethal; Pluripotency; Cell fate determination; Mammalian embryo
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The essential contribution of multiple maternal factors to early mammalian development is rapidly altering the view that mammals have a unique pattern of development compared to other species. Currently, over 60 maternal-effect mutations have been described in mammalian systems, including critical determinants of pluripotency. This data, combined with the evidence for lineage bias and differential gene expression in early blastomeres, strongly suggests that mammalian development is to some extent mosaic from the four-cell stage onward.
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