Related references
Note: Only part of the references are listed.Polyphosphoinositide binding domains: Key to inositol lipid biology
Gerald R. V. Hammond et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2015)
PI3K signalling in inflammation
P. T. Hawkins et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2015)
Measurement of PIP3 Levels Reveals an Unexpected Role for p110β in Early Adaptive Responses to p110α-Specific Inhibitors in Luminal Breast Cancer
Carlotta Costa et al.
CANCER CELL (2015)
Feedback Suppression of PI3Kα Signaling in PTEN-Mutated Tumors Is Relieved by Selective Inhibition of PI3Kβ
Sarit Schwartz et al.
CANCER CELL (2015)
Fc receptor inside-out signaling and possible impact on antibody therapy
Arianne M. Brandsma et al.
IMMUNOLOGICAL REVIEWS (2015)
The regulatory subunits of PI3Kγ control distinct neutrophil responses
Arnaud Deladeriere et al.
SCIENCE SIGNALING (2015)
A PI3K p110β-Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis
Haluk Yuzugullu et al.
NATURE COMMUNICATIONS (2015)
Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells
Julie Guillermet-Guibert et al.
PLOS GENETICS (2015)
The regulatory subunits of PI3Kγ control distinct neutrophil responses
Arnaud Deladeriere et al.
SCIENCE SIGNALING (2015)
Platelet PI3Kβ and GSK3 regulate thrombus stability at a high shear rate
Pierre-Alexandre Laurent et al.
BLOOD (2015)
Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor
Dejan Juric et al.
NATURE (2015)
PI3Kβ downstream of GPCRs – crucial partners in oncogenesis
Hashem A Dbouk et al.
Oncotarget (2015)
P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils
George Damoulakis et al.
JOURNAL OF CELL SCIENCE (2014)
Characterization of the Novel and Specific PI3Kα Inhibitor NVP-BYL719 and Development of the Patient Stratification Strategy for Clinical Trials
Christine Fritsch et al.
MOLECULAR CANCER THERAPEUTICS (2014)
The Phosphoinositide 3-Kinase Isoform PI3Kβ Regulates Osteoclast-Mediated Bone Resorption in Humans and Mice
David Gyori et al.
ARTHRITIS & RHEUMATOLOGY (2014)
Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells
Klaus Okkenhaug
ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 (2013)
Phosphatidylinositol-3,4,5-trisphosphate: Tool of choice for class I PI 3-kinases
Rachel Schnur Salamon et al.
BIOESSAYS (2013)
Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation
Pascal Furet et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms
Ralph Fritsch et al.
CELL (2013)
Long-term p110 PI3K inactivation exerts a beneficial effect on metabolism
Lazaros C. Foukas et al.
EMBO MOLECULAR MEDICINE (2013)
Specific inhibition of PI3K p110δ inhibits CSF-1-induced macrophage spreading and invasive capacity
Kellie A. Mouchemore et al.
FEBS JOURNAL (2013)
Class IA PI3K p110β Subunit Promotes Autophagy through Rab5 Small GTPase in Response to Growth Factor Limitation
Zhixun Dou et al.
MOLECULAR CELL (2013)
Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs)
Oscar Vadas et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction
Bo Shen et al.
CURRENT OPINION IN CELL BIOLOGY (2012)
Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor
S. Nylander et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2012)
Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA)
John E. Burke et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
CELL BIOLOGY G Protein-Coupled Receptor-Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness
Hashem A. Dbouk et al.
SCIENCE SIGNALING (2012)
Progress in the Preclinical Discovery and Clinical Development of Class I and Dual Class I/IV Phosphoinositide 3-Kinase (PI3K) Inhibitors
S. J. Shuttleworth et al.
CURRENT MEDICINAL CHEMISTRY (2011)
Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry
Jonathan Clark et al.
NATURE METHODS (2011)
PI3Kβ Plays a Critical Role in Neutrophil Activation by Immune Complexes
Suhasini Kulkarni et al.
SCIENCE SIGNALING (2011)
Deletion of the p110β isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo
Valerie Martin et al.
BLOOD (2010)
PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils
Karen E. Anderson et al.
BLOOD (2010)
Leukotriene B4 Augments and Restores FcγRs-dependent Phagocytosis in Macrophages
Fuyuki Okamoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Essential Role of the p110β Subunit of Phosphoinositide 3-OH Kinase in Male Fertility
Elisa Ciraolo et al.
MOLECULAR BIOLOGY OF THE CELL (2010)
The emerging mechanisms of isoform-specific PI3K signalling
Bart Vanhaesebroeck et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Dissection of the Interplay between Class I PI3Ks and Rac Signaling in Phagocytic Functions
Carlotta Costa et al.
THESCIENTIFICWORLDJOURNAL (2010)
Fine tuning the immune response with PI3K
David A. Fruman et al.
IMMUNOLOGICAL REVIEWS (2009)
Regulation of phosphoinositide 3-kinase expression in health and disease
Klaartje Kok et al.
TRENDS IN BIOCHEMICAL SCIENCES (2009)
CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks
Karen E. Anderson et al.
BLOOD (2008)
Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages
Evangelia A. Papakonstanti et al.
JOURNAL OF CELL SCIENCE (2008)
Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration
Mariona Graupera et al.
NATURE (2008)
Essential roles of PI(3)K-p110β in cell growth, metabolism and tumorigenesis
Shidong Jia et al.
NATURE (2008)
Membrane recognition by phospholipid-binding domains
Mark A. Lemmon
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ
Julie Guillermet-Guibert et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
PTEN-deficient cancers depend on PIK3CB
Susan Wee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Phosphoinositide 3-Kinase p110β Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development
Elisa Ciraolo et al.
SCIENCE SIGNALING (2008)
Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs
Attila Mocsai et al.
NATURE IMMUNOLOGY (2006)
A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling
Zachary A. Knight et al.
CELL (2006)
ITAM-based signaling beyond the adaptive immune response
S Fodor et al.
IMMUNOLOGY LETTERS (2006)
A pharmacological map of the PI3-K family defines a role for p110 alpha in insulin signaling
Zachary A. Knight et al.
CELL (2006)
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils
AM Condliffe et al.
BLOOD (2005)
PI 3-kinase p110β:: a new target for antithrombotic therapy
SP Jackson et al.
NATURE MEDICINE (2005)
Requirement for PI 3-kinase γ in macrophage migration to MCP-1 and CSF-1
GE Jones et al.
EXPERIMENTAL CELL RESEARCH (2003)
Essential role of phosphoinositide 3-kinase δ in neutrophil directional movement
C Sadhu et al.
JOURNAL OF IMMUNOLOGY (2003)
A highly efficient recombineering-based method for generating conditional knockout mutations
PT Liu et al.
GENOME RESEARCH (2003)
Association of phosphatidylinositol 3-kinase composed of p110β-catalytic and p85-regulatory subunits with the small GTPase Rab5
H Kurosu et al.
JOURNAL OF BIOCHEMISTRY (2001)
Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation
E Hirsch et al.
SCIENCE (2000)
Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant-mediated signal transduction
Z Li et al.
SCIENCE (2000)
Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration
T Sasaki et al.
SCIENCE (2000)