4.1 Article

Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

A modular master regulator landscape controls cancer transcriptional identity

Evan O. Paull et al.

Summary: Using a network-based approach, 407 master regulator proteins were identified to canalize individual cancer samples into 112 transcriptionally distinct tumor subtypes. These proteins were organized into 24 pan-cancer master regulator block modules regulating key cancer hallmarks and predictive of patient outcome. Genomic alterations were predicted to induce aberrant MR activity, providing insight into mechanisms linking tumor genetics and transcriptional identity.
Article Hematology

Salicylates enhance CRM1 inhibitor antitumor activity by induction of S-phase arrest and impairment of DNA-damage repair

Jithma P. Abeykoon et al.

Summary: Combining salicylates with CRM1 inhibitors demonstrates potent and broad antitumor activity in high-risk hematological malignancies and solid-organ cancers, while being non-toxic to nonmalignant cells and normal organs in mice.

BLOOD (2021)

Review Oncology

Therapeutic Targeting of Exportin-1 in Childhood Cancer

Basia Galinski et al.

Summary: Exportin-1 is a nuclear transport protein associated with inferior outcomes in cancer cells. Selinexor, an FDA-approved inhibitor of XPO1, has shown promising results in adult cancers but its efficacy in childhood cancers is still under investigation.

CANCERS (2021)

Article Hematology

Fimepinostat (CUDC-907) in patients with relapsed/refractory diffuse large B cell and high-grade B-cell lymphoma: report of a phase 2 trial and exploratory biomarker analyses

Daniel J. Landsburg et al.

Summary: Fimepinostat showed efficacy in DLBCL/HGBL patients with MYC alterations, leading to prolonged response duration. Combination therapies and biomarker-based patient selection strategies may improve response rates in future clinical trials.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

Article Oncology

Wilms Tumor (Nephroblastoma), Version 2.2021

Frank Balis et al.

Summary: The NCCN Guidelines for Wilms Tumor focus on screening, diagnosis, staging, treatment, and management of Wilms tumor. Five-year survival is over 90%, with recommendations for multidisciplinary team management and consultation with pediatric oncologists to minimize toxicity and maximize cure.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2021)

Article Biochemistry & Molecular Biology

Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages

Aleksandar Obradovic et al.

Summary: This study identified specific subpopulations and their master regulators through single-cell RNA sequencing, and found that TREM2/APOE/C1Q-positive macrophage infiltration could serve as a potential prognostic biomarker for ccRCC recurrence.
Article Oncology

Preclinical evaluation of XPO1 inhibition in Wilms tumors.

Michael Vincent Ortiz et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

Review Oncology

XPO1-dependent nuclear export as a target for cancer therapy

Nancy G. Azizian et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Review Multidisciplinary Sciences

The genomic landscape of pediatric cancers: Implications for diagnosis and treatment

E. Alejandro Sweet-Cordero et al.

SCIENCE (2019)

Article Medicine, General & Internal

Oral Selinexor-Dexamethasone for Triple-Class Refractory Multiple Myeloma

Ajai Chari et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Pediatrics

Precision medicine in pediatric oncology

Suzanne J. Forrest et al.

CURRENT OPINION IN PEDIATRICS (2018)

Article Multidisciplinary Sciences

The landscape of genomic alterations across childhood cancers

Susanne N. Groebner et al.

NATURE (2018)

Article Multidisciplinary Sciences

Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer

Tyler Risom et al.

NATURE COMMUNICATIONS (2018)

Article Medicine, Research & Experimental

Association between NER Pathway Gene Polymorphisms and Wilms Tumor Risk

Jinhong Zhu et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2018)

Meeting Abstract Hematology

hase I Study of the Selinexor in Relapsed/Refractory Childhood Acute Leukemia

Andrew E. Place et al.

BLOOD (2018)

Article Biochemical Research Methods

Systematic, network-based characterization of therapeutic target inhibitors

Yao Shen et al.

PLOS COMPUTATIONAL BIOLOGY (2017)

Review Oncology

The recurrent architecture of tumour initiation, progression and drug sensitivity

Andrea Califano et al.

NATURE REVIEWS CANCER (2017)

Article Multidisciplinary Sciences

Integrated genetic and pharmacologic interrogation of rare cancers

Andrew L. Hong et al.

NATURE COMMUNICATIONS (2016)

Article Medicine, General & Internal

Integrative Clinical Sequencing in the Management of Refractory or Relapsed Cancer in Youth

Rajen J. Mody et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2015)

Article Oncology

Age-related somatic mutations in the cancer genome

Brandon Milholland et al.

ONCOTARGET (2015)

Article Oncology

KPT-330 has antitumour activity against non-small cell lung cancer

H. Sun et al.

BRITISH JOURNAL OF CANCER (2014)

Article Biotechnology & Applied Microbiology

A community computational challenge to predict the activity of pairs of compounds

Mukesh Bansal et al.

NATURE BIOTECHNOLOGY (2014)

Review Oncology

Mechanisms by which SMARCB1 loss drives rhabdoid tumor growth

Kimberly H. Kim et al.

CANCER GENETICS (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Article Multidisciplinary Sciences

Mutational heterogeneity in cancer and the search for new cancer-associated genes

Michael S. Lawrence et al.

NATURE (2013)

Review Oncology

Children's Oncology Group's 2013 blueprint for research: Renal tumors

Jeffrey S. Dome et al.

PEDIATRIC BLOOD & CANCER (2013)

Review Multidisciplinary Sciences

Cancer Genome Landscapes

Bert Vogelstein et al.

SCIENCE (2013)

Review Pharmacology & Pharmacy

Nuclear export of proteins and drug resistance in cancer

Joel G. Turner et al.

BIOCHEMICAL PHARMACOLOGY (2012)

Article Biochemistry & Molecular Biology

Importin 7 and Exportin 1 Link c-Myc and p53 to Regulation of Ribosomal Biogenesis

Lior Golomb et al.

MOLECULAR CELL (2012)

Article Multidisciplinary Sciences

The transcriptional network for mesenchymal transformation of brain tumours

Maria Stella Carro et al.

NATURE (2010)

Review Oncology

The role of SMARCB1/INI1 in development of rhabdoid tumor

Charles W. M. Roberts et al.

CANCER BIOLOGY & THERAPY (2009)

Article Biochemical Research Methods

ARACNE: An algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context

AA Margolin et al.

BMC BIOINFORMATICS (2006)

Article Biochemical Research Methods

PAGE: Parametric analysis of gene set enrichment

SY Kim et al.

BMC BIOINFORMATICS (2005)

Review Oncology

The SWI/SNF complex - Chromatin and cancer

CWM Roberts et al.

NATURE REVIEWS CANCER (2004)