Journal
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
Volume 23, Issue 1, Pages 34-38Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.sjbs.2015.02.001
Keywords
4-(Phenylsulfonyl) morpholine; Antimicrobial agent; Modulation; Microbial resistance
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Funding
- Brazilian research agency FUNCAP
- Brazilian research agency CNPq
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The compound 4-(Phenylsulfonyl) morpholine belongs to the class of sulfonamides, which are widely used in the treatment of a large number of diseases caused by microorganisms. This compound has a morpholine group, which is also known for its antimicrobial properties. The aim of the present study was to investigate the antimicrobial and modulating activity of 4-(Phenylsulfonyl) morpholine against standard and multi-resistant strains of Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and strains of the fungi Candida albicans, C. tropicalis and C. krusei. Antimicrobial activity was assessed based on the minimum inhibitory concentration (MIC) using the microdilution method. MIC was >= 1024 mu g/mL for all microorganisms. Regarding modulating activity, the most representative effect occurred with the combination of 4-(Phenylsulfonyl) morpholine at a concentration of 128 mu g/mL (MIC 1/8) and amikacin against P. aeruginosa 03, with a reduction in MIC from 312.5 to 39.06 mu g/mL. (C) 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
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