☆ 4.6 Article

2022 KLCA-NCC Korea Practice Guidelines for the Management of Hepatocellular Carcinoma

KOREAN JOURNAL OF RADIOLOGY (2022)

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Review Gastroenterology & Hepatology

Impact of direct-acting antiviral regimens on mortality and morbidity outcomes in patients with chronic hepatitis c: Systematic review and meta-analysis

Yeva Sahakyan et al.

Summary: This study assessed the impact of direct-acting antiviral therapies (DAAs) on chronic hepatitis C (CHC) progression and mortality, finding that DAAs treatment and DAAs-related sustained virologic response (SVR) have protective effects on CHC progression and mortality.

JOURNAL OF VIRAL HEPATITIS (2021)

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Letter Medicine, General & Internal

Delayed Large Local Reactions to mRNA-1273 Vaccine against SARS-CoV-2

Kimberly G. Blumenthal et al.

Summary: Twelve patients developed delayed cutaneous reactions days after initial injection-related symptoms resolved. These reactions, some as severe as grade 3, were resolved in a few days with local therapy. After receiving the second vaccination, 6 patients had no recurrence of the local reaction, 3 had similar reactions to the initial injection reaction, and 3 had milder reactions.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Outcome of No-Touch Radiofrequency Ablation for Small Hepatocellular Carcinoma: A Multicenter Clinical Trial

Dong Ho Lee et al.

Summary: This study evaluated midterm clinical outcomes of monopolar no-touch radiofrequency ablation in patients with single hepatocellular carcinoma (HCC) ≤2.5 cm. Results showed that insufficient peritumoral parenchyma was the only significant predictive factor for failure of the no-touch technique. Local tumor progression occurred in 0.7% at 1 year and 1.6% at 2 years among the 140 participants.

RADIOLOGY (2021)

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Article Oncology

Optimal timing of combining sorafenib with trans-arterial chemoembolization in patients with hepatocellular carcinoma: A meta-analysis

Yanmei Dai et al.

Summary: The combination therapy of TACE and sorafenib significantly improves time to progression and progression-free survival, and reduces the risk of adverse reactions for unresectable HCC, especially when used before TACE. The meta-analysis showed slightly improved objective response rate and disease control rate in the TACE + sorafenib group, with higher incidence of adverse reactions compared to the TACE + placebo / alone group. Subgroup analysis indicated that the combination therapy before TACE was more effective in prolonging time to progression.

TRANSLATIONAL ONCOLOGY (2021)

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Article Multidisciplinary Sciences

Meta-analysis of the effect of the pringle maneuver on long-term oncological outcomes following liver resection

Elias Khajeh et al.

Summary: Through analyzing 19 studies including 7480 patients who underwent liver resection, the results show that the Pringle maneuver did not reduce the 1-year and 3-5-year overall survival rates and recurrence-free survival rates.

SCIENTIFIC REPORTS (2021)

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Article Oncology

Effects of Antiviral Therapy on HBV Reactivation and Survival in Hepatocellular Carcinoma Patients Undergoing Hepatic Artery Infusion Chemotherapy

Shousheng Liu et al.

Summary: HBV reactivation is more likely to occur in HBsAg-positive HCC patients undergoing HAIC without antiviral prophylaxis. Regular monitoring of HBV DNA and antiviral prophylaxis are suggested to prevent HBV reactivation and prolong the overall survival of these patients.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Efficacy of Local Therapy for Oligometastatic Hepatocellular Carcinoma: A Propensity Score Matched Analysis

Kangpyo Kim et al.

Summary: This study found that local therapy for oligometastatic lesions in patients with hepatocellular carcinoma can significantly improve survival rates and progression-free survival rates. Factors such as lower alpha-fetoprotein levels and the use of local therapy were identified as significant favorable prognostic factors.

JOURNAL OF HEPATOCELLULAR CARCINOMA (2021)

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Review Surgery

Anatomic versus non-anatomic resection of hepatocellular carcinoma with microvascular invasion: A systematic review and meta-analysis

Zhen Sun et al.

Summary: Anatomical resection (AR) showed higher overall survival (OS) and disease-free survival (DFS) rates compared to non-anatomical resection (NR) in hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI). Therefore, AR is recommended for well-presented liver function HCC patients predicted to have positive MVI.

ASIAN JOURNAL OF SURGERY (2021)

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Article Medicine, General & Internal

The efficacies of entecavir and tenofovir in terms of enhancing prognosis after curative treatment of hepatitis B virus-related hepatocellular carcinoma

Ji Hyun Lee et al.

Summary: The prognoses in terms of recurrence and death after curative treatment of HBV-related HCC were not statistically different between the ETV and TDF groups. Further validation studies are needed.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2021)

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Article Gastroenterology & Hepatology

Yttrium-90 Radioembolization for the Treatment of Solitary, Unresectable HCC: The LEGACY Study

Riad Salem et al.

Summary: The LEGACY study evaluated the efficacy of yttrium-90 glass microspheres in treating solitary, unresectable HCC <= 8 cm, showing promising response rates and durable responses in a multicenter setting.

HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Association of Metabolic Risk Factors With Risks of Cancer and All-Cause Mortality in Patients With Chronic Hepatitis B

Yun Bin Lee et al.

Summary: Long-term antiviral therapy cannot eliminate the risk of liver cancer in patients with chronic hepatitis B. The burden of metabolic risk factors is positively associated with an increased risk of developing HCC, non-HCC cancer, and all-cause mortality in these patients, with those having >= 3 metabolic risk factors showing higher risks.

HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Lenvatinib in combination with transarterial chemoembolization for treatment of unresectable hepatocellular carcinoma (uHCC): a retrospective controlled study

Zhigang Fu et al.

Summary: Combination treatment with TACE and lenvatinib shows significant improvement in clinical outcomes for unresectable HCC patients with manageable safety profile. The efficacy of this combination treatment should be further validated in prospective studies with larger sample size.

HEPATOLOGY INTERNATIONAL (2021)

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Article Oncology

A Phase 2 Study of Image-Guided Proton Therapy for Operable or Ablation-Treatable Primary Hepatocellular Carcinoma

Hiromitsu Iwata et al.

Summary: This study aimed to evaluate the outcome of image-guided proton therapy (IGPT) for operable or radiofrequency ablation-treatable primary hepatocellular carcinoma (HCC). Results showed high overall survival and local control rates among patients who received IGPT, with minimal changes in quality of life (QoL) scores after 1 year of treatment.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

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Article Oncology

Cost-Effectiveness of Adjuvant Immunotherapy With Cytokine-Induced Killer Cell for Hepatocellular Carcinoma Based on a Randomized Controlled Trial and Real-World Data

Jeong-Yeon Cho et al.

Summary: Research has shown that adjuvant CIK cell immunotherapy is more cost-effective than no adjuvant therapy for patients with hepatocellular carcinoma (HCC) who have undergone potentially curative treatment, attributed to prolonged survival, reduced HCC recurrence, and improved prognosis of recurrence.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Hepatic Resection Versus Transarterial Chemoembolization for Intermediate-Stage Hepatocellular Carcinoma: A Cohort Study

Linbin Lu et al.

Summary: This study analyzed the overall survival of patients with intermediate-stage HCC undergoing hepatic resection (HR) or transarterial chemoembolization (TACE). The results showed that HR was associated with improved overall survival, especially in patients with LDH levels higher than 192 U/L. Conversely, TACE may be more suitable for patients with LDH levels lower than or equal to 192 U/L.

FRONTIERS IN ONCOLOGY (2021)

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Letter Gastroenterology & Hepatology

Autoimmune hepatitis developing after coronavirus disease 2019 (COVID-19) vaccine: Causality or casualty?

Fernando Bril et al.

JOURNAL OF HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Systemic treatment of HCC in special populations

Lorenza Rimassa et al.

Summary: Recent years have witnessed significant progress in the systemic treatment of hepatocellular carcinoma (HCC), but there is a lack of high-quality evidence for patients with various comorbidities. Future clinical trials should be designed to specifically include patients with comorbidities to improve the safety and efficacy of HCC treatment in these subgroups.

JOURNAL OF HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Prognosis of French COVID-19 patients with chronic liver disease: A national retrospective cohort study for 2020

Vincent Mallet et al.

Summary: Chronic liver disease was found to increase the risk of COVID-19-related death in France in 2020. Therapeutic effort limitation may have contributed to the excess mortality in French residents with a liver-related complication or an alcohol use disorder.

JOURNAL OF HEPATOLOGY (2021)

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Article Medicine, General & Internal

Outcome of Initial Progression During Nivolumab Treatment for Hepatocellular Carcinoma: Should We Use iRECIST?

Dong Ho Lee et al.

Summary: The study evaluated the frequency of pseudoprogression in hepatocellular carcinoma patients undergoing nivolumab treatment in Korea, finding a low possibility of pseudoprogression and suggesting that iRECIST may not be necessary for HCC.

FRONTIERS IN MEDICINE (2021)

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Editorial Material Oncology

Short-term safety of the BNT162b2 mRNA COVID-19 vaccine in patients with cancer treated with immune checkpoint inhibitors

Barliz Waissengrin et al.

LANCET ONCOLOGY (2021)

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Article Multidisciplinary Sciences

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Dominik Pfister et al.

Summary: The study investigated the impact of NASH on immunotherapy response in HCC patients and found that NASH-HCC may be less responsive to immunotherapy. Aberrant T cell activation caused by NASH-related tissue damage led to impaired immune surveillance in HCC patients.

NATURE (2021)

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Article Oncology

Stereotactic body radiation therapy versus radiofrequency ablation for single small hepatocellular carcinoma: a propensity-score matching analysis of their impact on liver function and clinical outcomes

Masayuki Ueno et al.

Summary: In this study, changes in liver function and prognosis after SBRT or RFA in patients with single, small HCC were compared. The results showed that SBRT had a modestly negative impact on liver function but provided considerable local control of HCC.

JOURNAL OF GASTROINTESTINAL ONCOLOGY (2021)

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Article Surgery

A comparative study of postoperative outcomes between minimally invasive living donor hepatectomy and open living donor hepatectomy: The Korean organ transplantation registry

Jae Do Yang et al.

Summary: This study evaluated the safety and effectiveness of minimally invasive living donor hepatectomy in comparison with the open procedure. The results showed differences in complication rates and types between the two groups, with shorter hospitalization time in the minimally invasive group. To improve the feasibility of minimally invasive surgery, better surgical safety measures need to be ensured.

SURGERY (2021)

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Article Gastroenterology & Hepatology

Goal-directed fluid therapy vs. low central venous pressure during major open liver resections (GALILEO): a surgeon- and patient-blinded randomized controlled trial

Iris M. Jongerius et al.

Summary: This study compared low central venous pressure (low-CVP) and goal-directed fluid therapy (GDFT) during major liver resections, finding no significant differences in intraoperative blood loss, major morbidity, or quality of the surgical field between the two strategies. Larger randomized controlled trials are needed to confirm these findings.

HPB (2021)

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Review Oncology

Management of Hepatocellular Carcinoma in Japan: JSH Consensus Statements and Recommendations 2021 Update

Masatoshi Kudo et al.

Summary: The Clinical Practice Manual for Hepatocellular Carcinoma is based on evidence and expert consensus, focusing on pathology, diagnosis, and treatment. Different from the JSH Clinical Practice Guidelines, this manual emphasizes practicality and is written by a panel of experts from the JSH.

LIVER CANCER (2021)

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Article Oncology

Posttreatment after Lenvatinib in Patients with Advanced Hepatocellular Carcinoma

Keisuke Koroki et al.

Summary: The study investigated migration rates to posttreatment after lenvatinib therapy failure in patients with advanced HCC. Response to lenvatinib and discontinuation due to radiological progression, as well as male gender, were associated with higher chances of migrating to posttreatment. Sorafenib may not be suitable as a posttreatment agent, while regorafenib shows potential as a second-line therapy after lenvatinib.

LIVER CANCER (2021)

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Article Oncology

Comparison of Surgical Resection and Systemic Treatment for Hepatocellular Carcinoma with Vascular Invasion: National Cancer Database Analysis

Rajalakshmi Govalan et al.

Summary: The study suggests that surgical resection may provide better outcomes compared to systemic therapy for HCC patients with vascular invasion. Factors such as ethnicity, clinical characteristics, and treating facility type and region were associated with the likelihood of receiving surgical resection.

LIVER CANCER (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Percutaneous microwave ablation versus radiofrequency ablation of hepatocellular carcinoma: a meta-analysis of randomized controlled trials

Qian Yu et al.

Summary: A meta-analysis comparing the safety and efficacy of microwave ablation (MWA) and radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) in very early and early-stage patients found no significant differences in complete ablation rate, overall survival, recurrence-free survival, or complication rates between the two treatments. However, MWA was associated with a significantly shorter ablation time compared to RFA.

ABDOMINAL RADIOLOGY (2021)

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Article Oncology

Safety of PD-1/PD-L1 Inhibitors Combined With Palliative Radiotherapy and Anti-Angiogenic Therapy in Advanced Hepatocellular Carcinoma

Liting Zhong et al.

Summary: The combination of PD-1/PD-L1 inhibitors with palliative radiotherapy and anti-angiogenic therapy appears to be safe and effective in treating hepatocellular carcinoma, with a significant impact on patient survival. Further studies are needed to explore the clinical benefits of this triple therapy approach.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Efficacy of Stereotactic Body Radiotherapy in Patients With Hepatocellular Carcinoma Not Suitable for Transarterial Chemoembolization (HERACLES: HEpatocellular Carcinoma Stereotactic RAdiotherapy CLinical Efficacy Study)

Thomas B. Brunner et al.

Summary: The study findings indicate that SBRT is an effective and well-tolerated local treatment for patients with hepatocellular carcinoma, providing high rates of local control and maintaining quality of life for patients.

FRONTIERS IN ONCOLOGY (2021)

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Article Gastroenterology & Hepatology

Apatinib as second-line or later therapy in patients with advanced hepatocellular carcinoma (AHELP): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial

Shukui Qin et al.

Summary: This study demonstrates that apatinib significantly improved overall survival in patients with pretreated advanced hepatocellular carcinoma compared with placebo, with a manageable safety profile.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2021)

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Review Gastroenterology & Hepatology

Systematic review with meta-analysis: The effects of non-steroidal anti-inflammatory drugs and anti-platelet therapy on the incidence and recurrence of hepatocellular carcinoma

Regina Zi Hwei Tan et al.

Summary: The use of aspirin is supported in at-risk individuals to reduce the incidence of HCC and liver-related mortality, while NSAID treatment was associated with lower HCC recurrence following treatment.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2021)

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Article Oncology

Preoperative Estimated Risk of Microvascular Invasion is Associated with Prognostic Differences Following Liver Resection Versus Radiofrequency Ablation for Early Hepatitis B Virus-Related Hepatocellular Carcinoma

Shilei Bai et al.

Summary: The study aimed to compare prognosis between liver resection (LR) and percutaneous radiofrequency ablation (PRFA) for hepatocellular carcinoma (HCC) based on preoperative predicted microvascular invasion (MVI) risk. LR was found to be oncologically superior over PRFA for early HCC patients with predicted high-risk of MVI and associated with improved local disease control in these patients.

ANNALS OF SURGICAL ONCOLOGY (2021)

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Article Gastroenterology & Hepatology

Downstaging Outcomes for Hepatocellular Carcinoma: Results From the Multicenter Evaluation of Reduction in Tumor Size before Liver Transplantation (MERITS-LT) Consortium

Neil Mehta et al.

Summary: This study is the first multiregional study based on UNOS-DS criteria, showing a successful downstaging rate of >80% and similar efficacy of chemoembolization and yttrium-90 radioembolization as the initial downstaging treatment. Despite a 2-year post-LT survival rate of 95%, a high rate of tumor understaging was observed.

GASTROENTEROLOGY (2021)

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Article Gastroenterology & Hepatology

Prospective Study of Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma on Waitlist for Liver Transplant

Tiffany Cho-Lam Wong et al.

Summary: The study showed that stereotactic body radiation therapy (SBRT) as a bridge to liver transplantation for HCC has a significantly higher tumor control rate and lower risk of waitlist dropout compared to conventional bridging therapies, making it a safe alternative option.

HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Impact of tenofovir alafenamide vs. entecavir on hepatocellular carcinoma risk in patients with chronic hepatitis B

Hye Won Lee et al.

Summary: The study found that CHB patients treated with ETV and TAF have similar risk of developing HCC, suggesting that further research with larger sample sizes and longer follow-up periods is needed for validation.

HEPATOLOGY INTERNATIONAL (2021)

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Article Gastroenterology & Hepatology

Early response and safety of atezolizumab plus bevacizumab for unresectable hepatocellular carcinoma in patients who do not meet IMbrave150 eligibility criteria

Takuya Sho et al.

Summary: This study evaluated the real-world effectiveness of atezolizumab plus bevacizumab in patients with unresectable HCC, especially those who did not meet the eligibility criteria of the IMbrave150 trial. The results showed that the combination therapy had good safety and efficacy at the early treatment phase for most patients.

HEPATOLOGY RESEARCH (2021)

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Article Oncology

Safety, Efficacy, and Pharmacodynamics of Tremelimumab Plus Durvalumab for Patients With Unresectable Hepatocellular Carcinoma: Randomized Expansion of a Phase I/II Study

Robin Kate Kelley et al.

Summary: This study evaluated the treatment regimens for patients with hepatocellular carcinoma and found that all regimens were tolerable and clinically active, with the T300 + D regimen showing the most favorable benefit-risk profile. Early expansion of CD8+ lymphocytes was associated with treatment response across arms.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Article Oncology

Donafenib Versus Sorafenib in First-Line Treatment of Unresectable or Metastatic Hepatocellular Carcinoma: A Randomized, Open-Label, Parallel-Controlled Phase II-III Trial

Shukui Qin et al.

Summary: This study demonstrated that donafenib is more effective than sorafenib in treating advanced hepatocellular carcinoma, showing promise in improving patients' survival outcomes, and exhibiting favorable safety profile.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Article Gastroenterology & Hepatology

CheckMate 040 cohort 5: A phase I/II study of nivolumab in patients with advanced hepatocellular carcinoma and Child-Pugh B cirrhosis

Masatoshi Kudo et al.

Summary: Nivolumab monotherapy showed clinical activity and favorable safety in patients with Child-Pugh B status aHCC, with manageable treatment-related adverse events, suggesting its suitability for this patient population.

JOURNAL OF HEPATOLOGY (2021)

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Letter Gastroenterology & Hepatology

The mRNA COVID-19 vaccine - A rare trigger of autoimmune hepatitis?

Cathy McShane et al.

JOURNAL OF HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Effect of tenofovir alafenamide vs. tenofovir disoproxil fumarate on hepatocellular carcinoma risk in chronic hepatitis B

Hye Won Lee et al.

Summary: The study compared the effectiveness of TDF and TAF in preventing HCC development in CHB patients, showing no significant difference in risk between the two. Factors independently associated with an increased risk of HCC included male gender, liver cirrhosis, hepatitis B e antigen negativity, Fibrosis-4 index>3.25, and low albumin levels.

JOURNAL OF VIRAL HEPATITIS (2021)

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Article Gastroenterology & Hepatology

Regorafenib Efficacy After Sorafenib in Patients With Recurrent Hepatocellular Carcinoma After Liver Transplantation: A Retrospective Study

Massimo Iavarone et al.

Summary: This study demonstrates that regorafenib has a longer survival benefit in hepatocellular carcinoma patients after liver transplantation and sorafenib discontinuation, making it an effective second-line treatment option.

LIVER TRANSPLANTATION (2021)

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Article Public, Environmental & Occupational Health

Use of mRNA COVID-19 Vaccine After Reports of Myocarditis Among Vaccine Recipients: Update from the Advisory Committee on Immunization Practices — United States, June 2021

Julia W. Gargano et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

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Review Radiology, Nuclear Medicine & Medical Imaging

Perfluorobutane contrast-enhanced ultrasonography for the diagnosis of HCC: a systematic review and meta-analysis

Yichun Yang et al.

Summary: Perfluorobutane ultrasound contrast agent (P-CEUS) demonstrates high accuracy and reliability in the diagnosis of hepatocellular carcinoma (HCC), outperforming other imaging techniques. Meta-analysis of 9 studies reveals that P-CEUS has high sensitivity and specificity in characterizing HCC.

ABDOMINAL RADIOLOGY (2021)

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Article Medicine, General & Internal

Comparative Analysis of Lenvatinib and Hepatic Arterial Infusion Chemotherapy in Unresectable Hepatocellular Carcinoma: A Multi-Center, Propensity Score Study

Jaejun Lee et al.

Summary: The study revealed that in unresectable hepatocellular carcinoma patients, lenvatinib and hepatic artery infusion chemotherapy showed similar objective response rates and overall survival. However, for patients with a high tumor burden, hepatic artery infusion chemotherapy resulted in longer overall survival.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Oncology

Clinical Characteristics of Long-Term Survivors After Sorafenib Treatment for Unresectable Hepatocellular Carcinoma: A Korean National Multicenter Retrospective Cohort Study

Young Youn Cho et al.

Summary: This study evaluated prognostic factors of long-term survivors in Korean patients with unresectable HCC treated with sorafenib. Metformin use, hand-foot skin reaction, and concomitant treatment with chemoembolization or radiotherapy were identified as prognostic factors predicting long-term survival. Poor prognostic factors included a Child-Pugh score of B, presence of extrahepatic metastasis, main portal vein invasion, and elevated alpha-fetoprotein level.

JOURNAL OF HEPATOCELLULAR CARCINOMA (2021)

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Article Oncology

Living Donor Liver Transplantation: The Optimal Curative Treatment for Hepatocellular Carcinoma Even Beyond Milan Criteria

Altan Alim et al.

Summary: Liver transplantation is the preferred treatment for hepatocellular carcinoma, even in patients beyond Milan criteria. This study shows that the Milan criteria alone are not sufficient to predict survival after transplantation. Independent prognostic factors for survival include Alpha-fetoprotein level and vascular invasion status.

CANCER CONTROL (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Prospective Multi-Center Korean Registry of Transcatheter Arterial Chemoembolization with Drug-Eluting Embolics for Nodular Hepatocellular Carcinoma: A Two-Year Outcome Analysis

Myungsu Lee et al.

Summary: This study evaluated the two-year treatment outcomes of chemoembolization with drug-eluting embolics for nodular hepatocellular carcinoma in the Korean population. The results showed acceptable survival, tumor response, and safety profiles after a two-year follow-up. Good liver function was identified as a key predictor for patient overall survival, progression-free survival, and lesion tumor control.

KOREAN JOURNAL OF RADIOLOGY (2021)

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Article Gastroenterology & Hepatology

Non-invasive imaging criteria for the diagnosis of hepatocellular carcinoma in non-cirrhotic patients with chronic hepatitis B

Carlos Moctezuma-Velazquez et al.

Summary: The study evaluated the performance of EASL and LI-RADS criteria for diagnosing HCC in non-cirrhotic patients with chronic HBV infection. The criteria showed a positive predictive value comparable to that seen in patients with cirrhosis when the pre-test probability of HCC is >70%. These criteria could be used for diagnosing HCC in non-cirrhotic patients with HBV.

JHEP REPORTS (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

No-Touch vs. Conventional Radiofrequency Ablation Using Twin Internally Cooled Wet Electrodes for Small Hepatocellular Carcinomas: A Randomized Prospective Comparative Study

Yun Seok Suh et al.

Summary: This study aimed to compare the efficacy between no-touch (NT) radiofrequency ablation (RFA) and conventional RFA using twin internally cooled wet (TICW) electrodes in the bipolar mode for the treatment of small hepatocellular carcinomas (HCC). The results showed that NT-RFA using TICW electrodes in bipolar mode demonstrated significantly lower cumulative local tumor progression (LTP) rates than conventional RFA for small HCCs, which warrants further confirmation in larger studies.

KOREAN JOURNAL OF RADIOLOGY (2021)

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Article Surgery

Realization of improved outcomes following liver resection in hepatocellular carcinoma patients aged 75 years and older

Jong Man Kim et al.

Summary: This study compared the postoperative and long-term outcomes of liver resection in hepatocellular carcinoma patients older than 75 years of age according to operation period. The results showed that with advancements in surgical techniques and anatomical approach, as well as the use of laparoscopic LR, outcomes for elderly HCC patients have significantly improved in recent years.

ANNALS OF SURGICAL TREATMENT AND RESEARCH (2021)

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Article Gastroenterology & Hepatology

Hepatocellular carcinoma patients with portal vein thrombosis treated with robotic radiosurgery: Interim results of a prospective study

Debnarayan Dutta et al.

Summary: The study evaluated the role of SBRT with CyberKnife in Indian patients with hepatocellular carcinoma and portal vein thrombosis. Results showed that PVT response or recanalization after SBRT is a significant prognostic factor for survival in HCC-PVT patients.

INDIAN JOURNAL OF GASTROENTEROLOGY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Diagnostic Performance of 2018 KLCA-NCC Practice Guideline for Hepatocellular Carcinoma on Gadoxetic Acid-Enhanced MRI in Patients with Chronic Hepatitis B or Cirrhosis: Comparison with LI-RADS Version 2018

Sang Min Lee et al.

Summary: This study evaluated the performance of the 2018 KLCA-NCC Practice Guidelines and LI-RADS 2018 for diagnosing HCC using gadoxetic acid-enhanced MRI. The results showed that for lesions >= 2 cm, definite HCC had higher sensitivity than LR-5 without reducing specificity. Additionally, definite/probable HCC had similar sensitivity and specificity compared to LR-5/4.

KOREAN JOURNAL OF RADIOLOGY (2021)

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Article Medicine, General & Internal

Entecavir versus Tenofovir for the Prevention of Hepatocellular Carcinoma in Treatment-naive Chronic Hepatitis B Patients in Korea

HeeKyoung Choi et al.

Summary: This retrospective cohort study using nationwide claims data assessed the effects of ETV and TDF on preventing HCC in treatment-naive patients with chronic hepatitis B. The study found that in patients with chronic hepatitis B, ETV treatment did not result in a higher rate of HCC than TDF treatment.

JOURNAL OF KOREAN MEDICAL SCIENCE (2021)

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Article Oncology

Hepatobiliary Cancers, Version 2.2021

Al B. Benson III et al.

Summary: The NCCN Guidelines for Hepatobiliary Cancers provide recommendations for screening, diagnosis, staging, treatment, and management of HCC, gallbladder cancer, and cancer of the bile ducts. A multidisciplinary evaluation is crucial for determining optimal treatment strategies, with significant advancements in systemic treatment of HCC beyond traditional options like sorafenib.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2021)

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Article Surgery

Laparoscopic and open liver resection for hepatocellular carcinoma with Child-Pugh B cirrhosis: multicentre propensity score-matched study

R. Troisi et al.

Summary: For patients with Child-Pugh B cirrhosis undergoing liver resection for HCC, laparoscopic surgery is associated with lower blood loss, lower morbidity, and shorter hospital stay compared to open surgery. However, the 5-year overall and disease-free survival rates do not significantly differ between the two approaches. Patients without preoperative portal hypertension and Child-Pugh B7 cirrhosis may benefit most from laparoscopic liver surgery.

BRITISH JOURNAL OF SURGERY (2021)

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Article Oncology

Lenvatinib, toripalimab, plus hepatic arterial infusion chemotherapy versus lenvatinib alone for advanced hepatocellular carcinoma

Min-Ke He et al.

Summary: This study compared the efficacy and safety of lenvatinib, toripalimab, plus HAIC versus lenvatinib for advanced hepatocellular carcinoma, showing that the LeToHAIC group had significantly longer progression-free survival, overall survival, higher objective response rate, and more complete responses in target lesions. The combination therapy had acceptable toxic effects and may improve survival compared with lenvatinib alone.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2021)

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Article Oncology

Hepatic Arterial Infusion Chemotherapy Combined with Radiation Therapy for Advanced Hepatocellular Carcinoma with Tumor Thrombosis of the Main Trunk or Bilobar of the Portal Vein

Yumi Kosaka et al.

Summary: The combination therapy of HAIC and RT shows promising results for advanced HCC patients with Vp4, significantly improving overall survival and progression-free survival rates. Factors such as >50% of relative tumor volume in the liver and extrahepatic spread have been identified as significant factors affecting overall survival.

LIVER CANCER (2021)

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Article Oncology

Clinical Outcomes with Multikinase Inhibitors after Progression on First-Line Atezolizumab plus Bevacizumab in Patients with Advanced Hepatocellular Carcinoma: A Multinational Multicenter Retrospective Study

Changhoon Yoo et al.

Summary: In patients with advanced hepatocellular carcinoma who experienced disease progression on atezolizumab-bevacizumab, second-line treatment with multikinase inhibitors, predominantly sorafenib and lenvatinib, demonstrated comparable efficacy and manageable toxicities.

LIVER CANCER (2021)

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Article Oncology

Combined therapy with conventional trans-arterial chemoembolization (cTACE) and microwave ablation (MWA) for hepatocellular carcinoma >3-<5 cm

Mohamed M. A. Zaitoun et al.

Summary: The study compared the safety and efficacy of combined therapy with cTACE + MWA versus only TACE or MWA for treatment of Hepatocellular Carcinoma (HCC) >3-<5 cm. The results showed that the combined therapy group had higher complete response rate, lower recurrence rate, higher overall survival rate, and higher progression-free survival rate compared to the TACE or MWA alone groups.

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2021)

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Article Multidisciplinary Sciences

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Dominik Pfister et al.

Summary: The text discusses the impact of NASH on the development of HCC and the effect of immunotherapy, revealing the accumulation of exhausted and unconventionally activated CD8(+)PD1(+) T cells in NASH-affected livers. In preclinical models of NASH-induced HCC, anti-PD1 treatment led to an increase in HCC, with CD8(+) T cells contributing to this increase.

NATURE (2021)

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Article Surgery

Pathologic Response to Pretransplant Locoregional Therapy is Predictive of Patient Outcome After Liver Transplantation for Hepatocellular Carcinoma Analysis From the US Multicenter HCC Transplant Consortium

Joseph DiNorcia et al.

ANNALS OF SURGERY (2020)

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Article Oncology

Statin use and risk of liver cancer: Evidence from two population-based studies

Kim Tu Tran et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

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Article Immunology

Association of Prophylactic Anti-Hepatitis B Virus Therapy With Improved Long-term Survival in Patients With Hepatocellular Carcinoma Undergoing Transarterial Therapy

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CLINICAL INFECTIOUS DISEASES (2020)

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Statin Use and the Risk of Hepatocellular Carcinoma in Patients With Chronic Hepatitis B

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Predicting Hepatocellular Carcinoma Recurrence Beyond Milan Criteria After Liver Resection for Solitary Hepatocellular Carcinoma

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JOURNAL OF GASTROINTESTINAL SURGERY (2020)

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JOURNAL OF HEPATOLOGY (2020)

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Experience With Early Sorafenib Treatment With mTOR Inhibitors in Hepatocellular Carcinoma Recurring After Liver Transplantation

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TRANSPLANTATION (2020)

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A phase 2 multicenter study of stereotactic body radiotherapy for hepatocellular carcinoma: Safety and efficacy

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CANCER (2020)

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Comparison of tenofovir and entecavir on the risk of hepatocellular carcinoma and mortality in treatment-naive patients with chronic hepatitis B in Korea: a large-scale, propensity score analysis

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Long-term Effects of Repeat Hepatectomy vs Percutaneous Radiofrequency Ablation Among Patients With Recurrent Hepatocellular Carcinoma A Randomized Clinical Trial

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JAMA ONCOLOGY (2020)

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Magnetic Resonance Imaging With Extracellular Contrast Detects Hepatocellular Carcinoma With Greater Accuracy Than With Gadoxetic Acid or Computed Tomography

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AGA Clinical Practice Update on Screening and Surveillance for Hepatocellular Carcinoma in Patients with Nonalcoholic Fatty Liver Disease: Expert Review

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Liver Transplantation Outcomes in a US Multicenter Cohort of 789 Patients With Hepatocellular Carcinoma Presenting Beyond Milan Criteria

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HEPATOLOGY (2020)

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Tenofovir versus entecavir in lowering the risk of hepatocellular carcinoma development in patients with chronic hepatitis B: a critical systematic review and meta-analysis

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HEPATOLOGY INTERNATIONAL (2020)

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Effectiveness and feasibility of external beam radiotherapy for hepatocellular carcinoma with inferior vena cava and/or right atrium involvement: a multicenter trial in Korea (KROG 17-10)

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Addition of [18F]Fluorodeoxyglucose Positron Emission Tomography With Computed Tomography to Cross-Sectional Imaging Improves Staging and Alters Management in Hepatocellular Carcinoma

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LIVER TRANSPLANTATION (2020)

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PHARMACOLOGICAL RESEARCH (2020)

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Hepatic Resection Is Associated With Improved Long-Term Survival Compared to Radio-Frequency Ablation in Patients With Multifocal Hepatocellular Carcinoma

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Minimally Invasive Versus Open Liver Resection for Hepatocellular Carcinoma in the Setting of Portal Vein Hypertension: Results of an International Multi-institutional Analysis

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Microvascular Invasion and a Size Cutoff Value of 2 cm Predict Long-Term Oncological Outcome in Multiple Hepatocellular Carcinoma: Reappraisal of the American Joint Committee on Cancer Staging System and Validation Using the Surveillance, Epidemiology, and End-Results Database

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Living donor liver transplantation should be cautiously considered as initial treatment in recurrent hepatocellular carcinoma within the Milan criteria after curative liver resection

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Hepatobiliary phase hypointensity predicts progression to hepatocellular carcinoma for intermediate -high risk observations, but not time to progression

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BMJ GLOBAL HEALTH (2020)

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Stereotactic body radiation therapy for small (<= 5 cm) hepatocellular carcinoma not amenable to curative treatment: Results of a single-arm, phase II clinical trial

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ANNALS OF SURGICAL TREATMENT AND RESEARCH (2020)

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Radiotherapy for Hepatocellular Carcinoma Results in Comparable Survival to Radiofrequency Ablation: A Propensity Score Analysis

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Retrospective analysis of stereotactic body radiation therapy efficacy over radiofrequency ablation for hepatocellular carcinoma

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Statin Use is Associated with Decreased Hepatocellular Carcinoma Recurrence in Liver Transplant Patients

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SCIENTIFIC REPORTS (2019)

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Hepatic resection vs percutaneous radiofrequency ablation of hepatocellular carcinoma abutting right diaphragm

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Composite criteria using clinical and FDG PET/CT factors for predicting recurrence of hepatocellular carcinoma after living donor liver transplantation

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EUROPEAN RADIOLOGY (2019)

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GUT AND LIVER (2019)

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Direct-acting antivirals after successful treatment of early hepatocellular carcinoma improve survival in HCV-cirrhotic patients

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A multicenter study of entecavir vs. tenofovir on prognosis of treatment-naive chronic hepatitis B in South Korea

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Arterial subtraction images of gadoxetate-enhanced MRI improve diagnosis of early-stage hepatocellular carcinoma

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Sorafenib Plus Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, and Leucovorin vs Sorafenib Alone for Hepatocellular Carcinoma With Portal Vein Invasion A Randomized Clinical Trial

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JAMA ONCOLOGY (2019)

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Hypofractionated radiotherapy as a salvage treatment for recurrent hepatocellular carcinoma with inferior vena cava/right atrium tumor thrombus: a multi-center analysis

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BMC CANCER (2019)

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Urine protein: creatinine ratio vs 24-hour urine protein for proteinuria management: analysis from the phase 3 REFLECT study of lenvatinib vs sorafenib in hepatocellular carcinoma

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BRITISH JOURNAL OF CANCER (2019)

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HEPATOLOGY RESEARCH (2019)

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Neoadjuvant Three-Dimensional Conformal Radiotherapy for Resectable Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Randomized, Open-Label, Multicenter Controlled Study

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Lipophilic Statins and Risk for Hepatocellular Carcinoma and Death in Patients With Chronic Viral Hepatitis: Results From a Nationwide Swedish Population

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ANNALS OF INTERNAL MEDICINE (2019)

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Tyrosine kinase inhibitors and immune checkpoint inhibitors-induced thyroid disorders

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CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2019)

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JOURNAL OF HEPATOLOGY (2019)

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Article Radiology, Nuclear Medicine & Medical Imaging

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JOURNAL OF CLINICAL MEDICINE (2019)

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Article Oncology

Randomized, phase II trial of sequential hepatic arterial infusion chemotherapy and sorafenib versus sorafenib alone as initial therapy for advanced hepatocellular carcinoma: SCOOP-2 trial

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BMC CANCER (2019)

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Risk of Hepatocellular Carcinoma in Patients Treated With Entecavir vs Tenofovir for Chronic Hepatitis B A Korean Nationwide Cohort Study

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JAMA ONCOLOGY (2019)

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Article Oncology

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CANCER MEDICINE (2019)

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Article Oncology

Response to Lenvatinib Is Associated with Optimal RelativeDose Intensity in Hepatocellular Carcinoma: Experience in Clinical Settings

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CANCERS (2019)

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DIGESTIVE AND LIVER DISEASE (2019)

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Sorafenib with or without concurrent transarterial chemoembolization in patients with advanced hepatocellular carcinoma: The phase III STAH trial

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Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled, phase 3 trial

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18F-FDG PET/CT predicts microvascular invasion and early recurrence after liver resection for hepatocellular carcinoma A prospective observational study

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The 7th/8th American Joint Committee on Cancer and the Modified Union for International Cancer Control Staging System for Hepatocellular Carcinoma

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YONSEI MEDICAL JOURNAL (2019)

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Staged partial hepatectomy versus transarterial chemoembolization for the treatment of spontaneous hepatocellular carcinoma rupture: a multicenter analysis in Korea

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Systematic review with meta-analysis: recurrence of hepatocellular carcinoma following direct-acting antiviral therapy

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ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2018)

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CANCER CHEMOTHERAPY AND PHARMACOLOGY (2018)

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Novel Albumin-Bilirubin Grade-Based Risk Prediction Model for Patients with Hepatocellular Carcinoma Undergoing Chemoembolization

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DIGESTIVE DISEASES AND SCIENCES (2018)

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Surveillance Imaging and Alpha Fetoprotein for Early Detection of Hepatocellular Carcinoma in Patients With Cirrhosis: A Meta-analysis

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SIRveNIB: Selective Internal Radiation Therapy Versus Sorafenib in Asia-Pacific Patients With Hepatocellular Carcinoma

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Contrast ultrasound LI-RADS LR-5 identifies hepatocellular carcinoma in cirrhosis in a multicenter restropective study of 1,006 nodules

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EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma

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Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial

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Tivantinib for second-line treatment of MET-high, advanced hepatocellular carcinoma (METIV-HCC): a final analysis of a phase 3, randomised, placebo-controlled study

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Prognostic value of liver stiffness measurement for the liver-related surgical outcomes of patients under hepatic resection: A meta-analysis

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External beam radiation therapy to hepatocellular carcinoma involving inferior vena cava and/or right atrium: A meta-analysis and systemic review

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ANNALS OF SURGICAL TREATMENT AND RESEARCH (2018)

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Network meta-analysis of treatment regimens for inoperable advanced hepatocellular carcinoma with portal vein invasion

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Efficacy and Safety of Transarterial Chemoembolization Plus External Beam Radiotherapy vs Sorafenib in Hepatocellular Carcinoma With Macroscopic Vascular Invasion A Randomized Clinical Trial

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JAMA ONCOLOGY (2018)

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JAMA ONCOLOGY (2018)

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ONCOTARGETS AND THERAPY (2018)

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JAMA ONCOLOGY (2018)

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PRACTICAL RADIATION ONCOLOGY (2018)

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CLINICAL & TRANSLATIONAL ONCOLOGY (2018)

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A multicenter Phase II study of sorafenib in Japanese patients with advanced hepatocellular carcinoma and Child Pugh A and B class

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JAPANESE JOURNAL OF CLINICAL ONCOLOGY (2018)

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TRANSPLANTATION DIRECT (2018)

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JOURNAL OF HEPATOCELLULAR CARCINOMA (2018)

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ANNALS OF ONCOLOGY (2018)

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Pilot evaluation of PD-1 inhibition in metastatic cancer patients with a history of liver transplantation: the Mayo Clinic experience

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JOURNAL OF GASTROINTESTINAL ONCOLOGY (2018)

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CLINICAL AND MOLECULAR HEPATOLOGY (2018)

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2017 KASL clinical practice guidelines management of hepatitis C: Treatment of chronic hepatitis C

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CLINICAL AND MOLECULAR HEPATOLOGY (2018)

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LANCET GASTROENTEROLOGY & HEPATOLOGY (2018)

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AMERICAN JOURNAL OF GASTROENTEROLOGY (2017)

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LIVER INTERNATIONAL (2017)

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Liver Resection for Hepatocellular Carcinoma Associated With Hepatic Vein Invasion: A Japanese Nationwide Survey

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Antiplatelet Therapy and the Risk of Hepatocellular Carcinoma in Chronic Hepatitis B Patients on Antiviral Treatment

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HEPATOLOGY INTERNATIONAL (2017)

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INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2017)

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JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2017)

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Anatomical versus non-anatomical resection for solitary hepatocellular carcinoma without macroscopic vascular invasion: A propensity score matching analysis

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JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2017)

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Eung Chang Lee et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2017)

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Transarterial chemoembolization prior to liver transplantation for patients with hepatocellular carcinoma: A meta-analysis

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JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2017)

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Significance of preoperative fluorodeoxyglucose-positron emission tomography in prediction of tumor recurrence after liver transplantation for hepatocellular carcinoma patients: a Japanese multicenter study

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JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES (2017)

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Hepatocellular carcinoma risk following direct-acting antiviral HCV therapy: A systematic review, meta-analyses, and meta-regression

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Korean Multicenter Registry of Transcatheter Arterial Chemoembolization with Drug-Eluting Embolic Agents for Nodular Hepatocellular Carcinomas: Six-Month Outcome Analysis

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Dexamethasone Prophylaxis to Alleviate Postembolization Syndrome after Transarterial Chemoembolization for Hepatocellular Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled Study

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Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial

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Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial

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Efficacy and safety of selective internal radiotherapy with yttrium-90 resin microspheres compared with sorafenib in locally advanced and inoperable hepatocellular carcinoma (SARAH): an open-label randomised controlled phase 3 trial

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RADIOTHERAPY AND ONCOLOGY (2017)

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RADIOTHERAPY AND ONCOLOGY (2017)

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Adjuvant transarterial chemoembolization for patients after curative resection of hepatocellular carcinoma: a meta-analysis

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SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2017)

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Liver Cancer Emergence Associated with Antiviral Treatment: An Immune Surveillance Failure?

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SEMINARS IN LIVER DISEASE (2017)

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Evidence-Based Surveillance Imaging Schedule After Liver Transplantation for Hepatocellular Carcinoma Recurrence

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Wait Time of Less Than 6 and Greater Than 18 Months Predicts Hepatocellular Carcinoma Recurrence After Liver Transplantation: Proposing a Wait Time Sweet Spot

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TRANSPLANTATION (2017)

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Anterior vs conventional approach right hepatic resection for large hepatocellular carcinoma: A systematic review and meta-analysis

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WORLD JOURNAL OF GASTROENTEROLOGY (2017)

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Effects of radiofrequency ablation versus other ablating techniques on hepatocellular carcinomas: a systematic review and metaanalysis

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WORLD JOURNAL OF SURGICAL ONCOLOGY (2017)

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The effects of nonsteroidal anti-inflammatory drugs in the incident and recurrent risk of hepatocellular carcinoma: a meta-analysis

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ONCOTARGETS AND THERAPY (2017)

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The effect of antiviral therapy on patients with hepatitis B virus-related hepatocellular carcinoma after curative resection: a systematic review and meta-analysis

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ONCOTARGETS AND THERAPY (2017)

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A double blinded prospective randomized trial comparing the effect of anatomic versus non-anatomic resection on hepatocellular carcinoma recurrence

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HPB (2017)

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A Meta-analysis comparing the effect of anatomical resection vs. non-anatomical resection on the long-term outcomes for patients undergoing hepatic resection for hepatocellular carcinoma

Xinli Huang et al.

HPB (2017)

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Transarterial chemoembolization in hepatocellular carcinoma with portal vein tumor thrombosis: a systematic review and meta-analysis

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HPB (2017)

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Hepatectomy after down-staging of hepatocellular carcinoma with portal vein tumor thrombus using chemoradiotherapy: A retrospective cohort study

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INTERNATIONAL JOURNAL OF SURGERY (2017)

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Prognostic group stratification and nomogram for predicting overall survival in patients who received radiotherapy for abdominal lymph node metastasis from hepatocellular carcinoma: a multi-institutional retrospective study (KROG 15-02)

Youngkyong Kim et al.

ONCOTARGET (2017)

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High-dose radiotherapy is associated with better local control of bone metastasis from hepatocellular carcinoma

In-Hye Jung et al.

ONCOTARGET (2017)

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Combining 18F-FDG positron emission tomography with Up-to-seven criteria for selecting suitable liver transplant patients with advanced hepatocellular carcinoma

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SCIENTIFIC REPORTS (2017)

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Clinical Practice Patterns of Radiotherapy in Patients with Hepatocellular Carcinoma: A Korean Radiation Oncology Group Study (KROG 14-07)

Hyejung Cha et al.

CANCER RESEARCH AND TREATMENT (2017)

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Noncirrhotic hepatocellular carcinoma: etiology and occult hepatitis B virus infection in a hepatitis B virus-endemic area

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THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2017)

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Beneficial Effect of Maintaining Hepatic Reserve during Chemotherapy on the Outcomes of Patients with Hepatocellular Carcinoma

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LIVER CANCER (2017)

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Benign nodules in post-Fontan livers can show imaging features considered diagnostic for hepatocellular carcinoma

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ABDOMINAL RADIOLOGY (2017)

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Validation of a Risk Estimation of Tumor Recurrence After Transplant (RETREAT) Score for Hepatocellular Carcinoma Recurrence After Liver Transplant

Neil Mehta et al.

JAMA ONCOLOGY (2017)

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Preoperative adjuvant transarterial chemoembolization cannot improve the long term outcome of radical therapies for hepatocellular carcinoma

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SCIENTIFIC REPORTS (2017)

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Gd-EOB-DTPA-enhanced MRI for evaluation of liver function: Comparison between signal-intensity-based indices and T1 relaxometry

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SCIENTIFIC REPORTS (2017)

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Low Tube Voltage Liver MDCT with Sinogram-Affirmed Iterative Reconstructions for the Detection of Hepatocellular Carcinoma

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Living or Brain-dead Donor Liver Transplantation for Hepatocellular Carcinoma A Multicenter, Western, Intent-to-treat Cohort Study

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Randomized clinical trial of hepatic resection versus radiofrequency ablation for early-stage hepatocellular carcinoma

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Prediction of Hepatocellular Carcinoma Recurrence Beyond Milan Criteria After Resection

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ANNALS OF SURGERY (2017)

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Progressive Hypofractionated Carbon-Ion Radiotherapy for Hepatocellular Carcinoma: Combined Analyses of 2 Prospective Trials

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Meta-analysis of determinants of survival following treatment of recurrent hepatocellular carcinoma

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BRITISH JOURNAL OF SURGERY (2017)

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Subtraction Images of Gadoxetic Acid-Enhanced MRI: Effect on the Diagnostic Performance for Focal Hepatic Lesions in Patients at Risk for Hepatocellular Carcinoma

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AMERICAN JOURNAL OF ROENTGENOLOGY (2017)

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Impact of Pretransplant Bridging Locoregional Therapy for Patients With Hepatocellular Carcinoma Within Milan Criteria Undergoing Liver Transplantation Analysis of 3601 Patients From the US Multicenter HCC Transplant Consortium

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ANNALS OF SURGERY (2017)

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Sorafenib in combination with transarterial chemoembolisation in patients with unresectable hepatocellular carcinoma (TACE 2): a randomised placebo-controlled, double-blind, phase 3 trial

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ANNALS OF SURGERY (2017)

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CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2017)

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Long-term outcomes of proton beam therapy in patients with previously untreated hepatocellular carcinoma

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CANCER SCIENCE (2017)

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BRITISH JOURNAL OF SURGERY (2016)

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Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update

S. K. Sarin et al.

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Beom Kyung Kim et al.

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Prognostic significance of adverse events in patients with hepatocellular carcinoma treated with sorafenib

Alessandro Granito et al.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2016)

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A randomized controlled trial on patients with or without adjuvant autologous cytokine-induced killer cells after curative resection for hepatocellular carcinoma

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Comparative 13-year meta-analysis of the sensitivity and positive predictive value of ultrasound, CT, and MRI for detecting hepatocellular carcinoma

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Sorafenib plus hepatic arterial infusion chemotherapy with cisplatin versus sorafenib for advanced hepatocellular carcinoma: randomized phase II trial

M. Ikeda et al.

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Serum Tumor Markers Provide Refined Prognostication in Selecting Liver Transplantation Candidate for Hepatocellular Carcinoma Patients Beyond the Milan Criteria

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Phase 2 study of stereotactic body radiotherapy and optional transarterial chemoembolization for solitary hepatocellular carcinoma not amenable to resection and radiofrequency ablation

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CANCER (2016)

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Adjuvant immunotherapy with autologous cytokine-induced killer cells for hepatocellular carcinoma patients after curative resection, a systematic review and meta-analysis

Haiqing Wang et al.

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Effect of perioperative parecoxib sodium on postoperative pain control for transcatheter arterial chemoembolization for inoperable hepatocellular carcinoma: a prospective randomized trial

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Y90 Radioembolization Significantly Prolongs Time to Progression Compared With Chemoembolization in Patients With Hepatocellular Carcinoma

Riad Salem et al.

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Lipiodol Transarterial Chemoembolization for Hepatocellular Carcinoma: A Systematic Review of Efficacy and Safety Data

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Radiation Therapy and Palliative Care Prolongs the Survival of Hepatocellular Carcinoma Patients with Bone Metastases

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Randomized Clinical Trial Comparing Proton Beam Radiation Therapy with Transarterial Chemoembolization for Hepatocellular Carcinoma: Results of an Interim Analysis

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INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2016)

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Hepatocellular Carcinoma Screening and Surveillance Practice Guidelines and Real-Life Practice

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Multi-Institutional Phase II Study of High-Dose Hypofractionated Proton Beam Therapy in Patients With Localized, Unresectable Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma

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Early occurrence and recurrence of hepatocellular carcinoma in HCV-related cirrhosis treated with direct-acting antivirals

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Diagnostic criteria for hepatocellular carcinoma ≤3 cm with hepatocyte-specific contrast-enhanced magnetic resonance imaging

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Observational registry of sorafenib use in clinical practice across Child-Pugh subgroups: The GIDEON study

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Sorafenib or placebo plus TACE with doxorubicin-eluting beads for intermediate stage HCC: The SPACE trial

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Unexpected high rate of early tumor recurrence in patients with HCV-related HCC undergoing interferon-free therapy

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Lack of evidence of an effect of direct-acting antivirals on the recurrence of hepatocellular carcinoma: Data from three ANRS cohorts

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Diagnostic accuracy of liver imaging reporting and data system (LI-RADS) v2014 for intrahepatic mass-forming cholangiocarcinomas in patients with chronic liver disease on gadoxetic acid-enhanced MRI

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Impact of Spontaneous Tumor Rupture on Prognosis of Patients With T4 Hepatocellular Carcinoma

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Is radiofrequency ablation applicable for recurrent hepatocellular carcinoma after liver transplantation?

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JOURNAL OF SURGICAL RESEARCH (2016)

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Portal Vein Embolization Followed by Right-Side Hemihepatectomy for Hepatocellular Carcinoma Patients: A Japanese Multi-Institutional Study

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JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2016)

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Efficacy and Safety of Radiofrequency Ablation Combined with Transcatheter Arterial Chemoembolization for Hepatocellular Carcinomas Compared with Radiofrequency Ablation Alone: A Time-to-Event Meta-Analysis

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Radiotherapy for Adrenal Metastasis from Hepatocellular Carcinoma: AMulti-Institutional Retrospective Study (KROG 13-05)

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PLOS ONE (2016)

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Survival Analysis over 28 Years of 173,378 Patients with Hepatocellular Carcinoma in Japan

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Consensus for Radiotherapy in Hepatocellular Carcinoma from The 5th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2014): Current Practice and Future Clinical Trials

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PLOS ONE (2016)

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Survival outcomes of hepatic resection compared with transarterial chemoembolization or sorafenib for hepatocellular carcinoma with portal vein tumor thrombosis

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Imaging features of subcentimeter hypointense nodules on gadoxetic acid-enhanced hepatobiliary phase MR imaging that progress to hypervascular hepatocellular carcinoma in patients with chronic liver disease

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ACTA RADIOLOGICA (2015)

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Antiviral Therapy Improves Postoperative Survival in Patients With Hepatocellular Carcinoma A Randomized Controlled Trial

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ANNALS OF SURGERY (2015)

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ANNALS OF SURGERY (2015)

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The role of clinically significant portal hypertension in hepatic resection for hepatocellular carcinoma patients: a propensity score matching analysis

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BMC CANCER (2015)

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Impact of Long-Term Tenofovir Disoproxil Fumarate on Incidence of Hepatocellular Carcinoma in Patients With Chronic Hepatitis B

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CANCER (2015)

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Elevated Alpha-Fetoprotein Differential Diagnosis - Hepatocellular Carcinoma and Other Disorders

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CLINICS IN LIVER DISEASE (2015)

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Noninvasive diagnosis of hepatocellular carcinoma on gadoxetic acid-enhanced MRI: can hypointensity on the hepatobiliary phase be used as an alternative to washout?

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EUROPEAN RADIOLOGY (2015)

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Evaluation of Early-Stage Hepatocellular Carcinoma by Magnetic Resonance Imaging With Gadoxetic Acid Detects Additional Lesions and Increases Overall Survival

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GASTROENTEROLOGY (2015)

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Downstaging of hepatocellular cancer before liver transplant: Long-term outcome compared to tumors within Milan criteria

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HEPATOLOGY (2015)

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Multicenter Randomized Controlled Trial of Percutaneous Cryoablation Versus Radiofrequency Ablation in Hepatocellular Carcinoma

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HEPATOLOGY (2015)

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Adjuvant Intrahepatic Injection Iodine-131-Lipiodol Improves Prognosis of Patients with Hepatocellular Carcinoma After Resection: a Meta-Analysis

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INDIAN JOURNAL OF SURGERY (2015)

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Sorafenib treatment in Child-Pugh A and B patients with advanced hepatocellular carcinoma: safety, efficacy and prognostic factors

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INVESTIGATIONAL NEW DRUGS (2015)

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Early Versus Delayed Initiation of Concurrent Palliative Oncology Care: Patient Outcomes in the ENABLE III Randomized Controlled Trial

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Randomized Controlled Trial of the Prophylactic Effect of Urea-Based Cream on Sorafenib-Associated Hand-Foot Skin Reactions in Patients With Advanced Hepatocellular Carcinoma

ZhengGang Ren et al.

JOURNAL OF CLINICAL ONCOLOGY (2015)

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SEARCH: A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial of Sorafenib Plus Erlotinib in Patients With Advanced Hepatocellular Carcinoma

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Linifanib Versus Sorafenib in Patients With Advanced Hepatocellular Carcinoma: Results of a Randomized Phase III Trial

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Pseudoprogression and Immune-Related Response in Solid Tumors

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Hepatitis B viral load predicts survival in hepatocellular carcinoma patients treated with sorafenib

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JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2015)

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Local Recurrence after Radiofrequency Ablation of Hepatocellular Carcinoma: Treatment Choice and Outcome

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JOURNAL OF GASTROINTESTINAL SURGERY (2015)

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Non-hypervascular hepatobiliary phase hypointense nodules on gadoxetic acid-enhanced MRI: Risk of HCC recurrence after radiofrequency ablation

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Retreatment with TACE: The ABCR SCORE, an aid to the decision-making process

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Dynamic-contrast-enhanced magnetic resonance imaging of cirrhotic liver parenchyma: A comparison between gadolinium-diethylenetriamine pentaacetic acid and gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid

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JOURNAL OF THE CHINESE MEDICAL ASSOCIATION (2015)

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2014 Korean Liver Cancer Study Group-National Cancer Center Korea Practice Guideline for the Management of Hepatocellular Carcinoma

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Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib (REACH): a randomised, double-blind, multicentre, phase 3 trial

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LANCET ONCOLOGY (2015)

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Adjuvant sorafenib for hepatocellular carcinoma after resection or ablation (STORM): a phase 3, randomised, double-blind, placebo-controlled trial

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LANCET ONCOLOGY (2015)

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Pilot randomized trial of selective internal radiation therapy vs. chemoembolization in unresectable hepatocellular carcinoma

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LIVER INTERNATIONAL (2015)

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Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study

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LIVER TRANSPLANTATION (2015)

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RADIOGRAPHICS (2015)

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Hepatocellular Carcinoma: Diagnostic Performance of Multidetector CT and MR Imaging-A Systematic Review and Meta-Analysis

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RADIOLOGY (2015)

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Aggressive Intrasegmental Recurrence of Hepatocellular Carcinoma after Radiofrequency Ablation: Risk Factors and Clinical Significance

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RADIOLOGY (2015)

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Small Hepatocellular Carcinoma: Radiofrequency Ablation versus Nonanatomic Resection-Propensity Score Analyses of Long-term Outcomes

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Functional assessment versus conventional volumetric assessment in the prediction of operative outcomes after major hepatectomy

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A systematic review and meta-analysis of portal vein ligation versus portal vein embolization for elective liver resection

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SURGERY (2015)

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TRANSPLANTATION (2015)

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Long-Term Outcome After Resection of Huge Hepatocellular Carcinoma ≥10 cm: Single-Institution Experience with 471 Patients

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WORLD JOURNAL OF SURGERY (2015)

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Radiofrequency ablation versus percutaneous ethanol injection for hepatocellular carcinoma: a meta-analysis of randomized controlled trials

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WORLD JOURNAL OF SURGICAL ONCOLOGY (2015)

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Adjuvant stereotactic body radiotherapy following transarterial chemoembolization in patients with non-resectable hepatocellular carcinoma tumours of ≥3 cm

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HPB (2015)

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FibroScan predicts ascites after liver resection for hepatitis B virus-related hepatocellular carcinoma: A prospective cohort study

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INTERNATIONAL JOURNAL OF SURGERY (2015)

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Evaluation of sorafenib treatment and hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma: a comparative study using the propensity score matching method

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CANCER MEDICINE (2015)

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Effectiveness of Sorafenib in Patients with Transcatheter Arterial Chemoembolization (TACE) Refractory and Intermediate-Stage Hepatocellular Carcinoma

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Transcatheter Arterial Chemoembolization Plus Radiotherapy Compared With Chemoembolization Alone for Hepatocellular Carcinoma A Systematic Review and Meta-analysis

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JAMA ONCOLOGY (2015)

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Benefit of Treating Hepatocellular Carcinoma Recurrence after Liver Transplantation and Analysis of Prognostic Factors for Survival in a Large Euro-American Series

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ANNALS OF SURGICAL ONCOLOGY (2015)

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Randomized Comparison of Selective Internal Radiotherapy (SIRT) Versus Drug-Eluting Bead Transarterial Chemoembolization (DEB-TACE) for the Treatment of Hepatocellular Carcinoma

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CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY (2015)

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Hepatic arterial infusion chemotherapy with fine-powder cisplatin and iodized-oil suspension in patients with intermediate-stage and advanced-stage (Barcelona Clinic Liver Cancer stage-B or stage-C) hepatocellular carcinoma: multicenter phase-II clinical study

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INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2015)

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A comparative study between sorafenib and hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis

Do Seon Song et al.

JOURNAL OF GASTROENTEROLOGY (2015)

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Article Gastroenterology & Hepatology

EASL–EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma

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JOURNAL OF HEPATOLOGY (2015)

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Reactivation of Hepatitis B Virus in HBsAg-Negative Patients with Hepatocellular Carcinoma

Jeong Won Jang et al.

PLOS ONE (2015)

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Economic Burden of Cancer in Korea during 2000-2010

Kwang-Sig Lee et al.

CANCER RESEARCH AND TREATMENT (2015)

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Phase I Dose-Escalation Study of Proton Beam Therapy for Inoperable Hepatocellular Carcinoma

Tae Hyun Kim et al.

CANCER RESEARCH AND TREATMENT (2015)

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Article Oncology

Stereotactic body radiotherapy for small hepatocellular carcinoma: A retrospective outcome analysis in 185 patients

Naoko Sanuki et al.

ACTA ONCOLOGICA (2014)

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Anatomic resection reduces the recurrence of solitary hepatocellular carcinoma ≤ 5 cm without macrovascular invasion

Atsushi Kudo et al.

AMERICAN JOURNAL OF SURGERY (2014)

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Establishment of a Multidisciplinary Hepatocellular Carcinoma Clinic is Associated with Improved Clinical Outcome

Adam C. Yopp et al.

ANNALS OF SURGICAL ONCOLOGY (2014)

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Surgical Resection After Down-Staging of Locally Advanced Hepatocellular Carcinoma by Localized Concurrent Chemoradiotherapy

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ANNALS OF SURGICAL ONCOLOGY (2014)

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Perpetuating proficiency in donor right hepatectomy for living donor liver transplantation

See Ching Chan et al.

ASIAN JOURNAL OF SURGERY (2014)

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Role of antiviral treatment for HCC prevention

Massimo Colombo et al.

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY (2014)

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Overall survival in response to sorafenib versus radiotherapy in unresectable hepatocellular carcinoma with major portal vein tumor thrombosis: propensity score analysis

Takahide Nakazawa et al.

BMC GASTROENTEROLOGY (2014)

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Randomised controlled trial of doxorubicin-eluting beads vs conventional chemoembolisation for hepatocellular carcinoma

R. Golfieri et al.

BRITISH JOURNAL OF CANCER (2014)

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Article Cardiac & Cardiovascular Systems

Trends in Utilization of Transarterial Treatments for Hepatocellular Carcinoma: Results of a Survey by the Italian Society of Interventional Radiology

Irene Bargellini et al.

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY (2014)

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Article Cardiac & Cardiovascular Systems

Comparison of Local Control in Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma aparts per thousandcurrency sign6 cm With or Without Intraprocedural Monitoring of the Embolized Area Using Cone-Beam Computed Tomography

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Oxaliplatin-based Chemotherapy: A New Option in Advanced Hepatocellular Carcinoma. A Systematic Review and Pooled Analysis

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The prognosis and treatment outcomes of patients with recurrent hepatocellular carcinoma after liver transplantation

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CLINICAL TRANSPLANTATION (2014)

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Can low-dose CT with iterative reconstruction reduce both the radiation dose and the amount of iodine contrast medium in a dynamic CT study of the liver?

Hiroto Takahashi et al.

EUROPEAN JOURNAL OF RADIOLOGY (2014)

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Development of Hong Kong Liver Cancer Staging System With Treatment Stratification for Patients With Hepatocellular Carcinoma

Thomas Yau et al.

GASTROENTEROLOGY (2014)

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Mortality, Liver Transplantation, and Hepatocellular Carcinoma Among Patients With Chronic Hepatitis B Treated With Entecavir vs Lamivudine

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Feasibility and efficacy of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma after sorafenib

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HEPATOLOGY RESEARCH (2014)

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Salvage treatment for local recurrence of hepatocellular carcinoma after local ablation therapy

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GIDEON (Global Investigation of therapeutic DEcisions in hepatocellular carcinoma and Of its treatment with sorafeNib): second interim analysis

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INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2014)

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A Prospective Phase 2 Multicenter Study for the Efficacy of Radiation Therapy Following Incomplete Transarterial Chemoembolization in Unresectable Hepatocellular Carcinoma

Chihwan Choi et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2014)

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Gemcitabine and oxaliplatin chemotherapy for advanced hepatocellular carcinoma after failure of anti-angiogenic therapies

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INVESTIGATIONAL NEW DRUGS (2014)

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Effect of Everolimus on Survival in Advanced Hepatocellular Carcinoma After Failure of Sorafenib The EVOLVE-1 Randomized Clinical Trial

Andrew X. Zhu et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2014)

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Radiofrequency Ablation Versus Hepatic Resection for Small Hepatocellular Carcinoma A Meta- analysis of Randomized Controlled Trials

Xingshun Qi et al.

JOURNAL OF CLINICAL GASTROENTEROLOGY (2014)

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A randomized phase II study of autologous cytokine-induced killer cells in treatment of hepatocelluar carcinoma

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JOURNAL OF CLINICAL IMMUNOLOGY (2014)

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Systematic review of efficacy and outcomes of salvage liver transplantation after primary hepatic resection for hepatocellular carcinoma

Daniel L. Chan et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014)

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Role of lamivudine with transarterial chemoembolization in the survival of patients with hepatocellular carcinoma

Xiaojing Xu et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014)

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Radiotherapy for patients with unresectable advanced hepatocellular carcinoma with invasion to intrahepatic large vessels: Efficacy and outcomes

Yoshiaki Tanaka et al.

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Impact of postoperative hepatitis B virus reactivation in hepatocellular carcinoma patients who formerly had naturally suppressed virus

Jung Il Lee et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014)

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Clinical outcomes of a cohort series of patients with hepatocellular carcinoma in a hepatitis B virus-endemic area

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JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014)

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Early palliative care for patients with advanced cancer: a cluster-randomised controlled trial

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The feasibility of combined transcatheter arterial chemoembolization and radiotherapy for advanced hepatocellular carcinoma

Ju-Yeon Cho et al.

LIVER INTERNATIONAL (2014)

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Transarterial Chemoembolization Failure/Refractoriness: JSH-LCSGJ Criteria 2014 Update

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Surveillance and Diagnostic Algorithm for Hepatocellular Carcinoma Proposed by the Liver Cancer Study Group of Japan: 2014 Update

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Efficacy of Sorafenib in Intermediate-Stage Hepatocellular Carcinoma Patients Refractory to Transarterial Chemoembolization

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Does 18F-FDG Positron Emission Tomography-Computed Tomography Have a Role in Initial Staging of Hepatocellular Carcinoma?

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Radiofrequency Ablation of Hepatocellular Carcinoma as First-Line Treatment: Long-term Results and Prognostic Factors in 162 Patients with Cirrhosis

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Small (≤1-cm) Hepatocellular Carcinoma: Diagnostic Performance and Imaging Features at Gadoxetic Acid-enhanced MR Imaging

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Small Single-Nodule Hepatocellular Carcinoma: Comparison of Transarterial Chemoembolization, Radiofrequency Ablation, and Hepatic Resection by Using Inverse Probability Weighting

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Effectiveness and safety of proton beam therapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis

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STRAHLENTHERAPIE UND ONKOLOGIE (2014)

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Epirubicin, Cisplatin, 5-FU combination chemotherapy in sorafenib-refractory metastatic hepatocellular carcinoma

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WORLD JOURNAL OF GASTROENTEROLOGY (2014)

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Propensity score analysis demonstrated the prognostic advantage of anatomical liver resection in hepatocellular carcinoma

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WORLD JOURNAL OF GASTROENTEROLOGY (2014)

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LIVER CANCER (2014)

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Conventional oral systemic chemotherapy for postoperative hepatocellular carcinoma: A systematic review

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MOLECULAR AND CLINICAL ONCOLOGY (2014)

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Validation of diagnostic criteria using gadoxetic acid-enhanced and diffusion-weighted MR imaging for small hepatocellular carcinoma (≤ 2.0 cm) in patients with hepatitis-induced liver cirrhosis

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Surveillance for hepatocellular cancer with ultrasonography vs. computed tomography - a randomised study

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ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2013)

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Hepatocellular Carcinoma Surveillance at 4-vs. 12-Month Intervals for Patients With Chronic Viral Hepatitis : A Randomized Study in Community

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AMERICAN JOURNAL OF GASTROENTEROLOGY (2013)

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Detection of Hepatocellular Carcinoma at Advanced Stages Among Patients in the HALT-C Trial: Where Did Surveillance Fail?

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AMERICAN JOURNAL OF GASTROENTEROLOGY (2013)

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Prevalence and Management of Pain by Different Age Groups of Korean Cancer Patients

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AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE (2013)

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Hepatocellular Carcinoma in Chronic Hepatitis C in the Absence of Advanced Fibrosis or Cirrhosis

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AMERICAN JOURNAL OF ROENTGENOLOGY (2013)

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Eradication of Hepatitis C Virus Infection and the Development of Hepatocellular Carcinoma A Meta-analysis of Observational Studies

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ANNALS OF INTERNAL MEDICINE (2013)

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Sorafenib in patients with Child-Pugh class A and B advanced hepatocellular carcinoma: a prospective feasibility analysis

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Long-Term Survival Analysis of Pure Laparoscopic Versus Open Hepatectomy for Hepatocellular Carcinoma in Patients With Cirrhosis A Single-Center Experience

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Combination treatment of localized concurrent chemoradiation therapy and transarterial chemoembolization in locally advanced hepatocellular carcinoma with intrahepatic metastasis

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Coffee Reduces Risk for Hepatocellular Carcinoma: An Updated Meta-analysis

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EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2013)

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Radiofrequency ablation plus chemoembolization versus radiofrequency ablation alone for hepatocellular carcinoma: a meta-analysis of randomized-controlled trials

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Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studies

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Entecavir Treatment Reduces Hepatic Events and Deaths in Chronic Hepatitis B Patients With Liver Cirrhosis

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A modified TNM-7 staging system to better predict the survival in patients with hepatocellular carcinoma after hepatectomy

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Brivanib Versus Sorafenib As First-Line Therapy in Patients With Unresectable, Advanced Hepatocellular Carcinoma: Results From the Randomized Phase III BRISK-FL Study

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Randomized, Multicenter, Open-Label Study of Oxaliplatin Plus Fluorouracil/Leucovorin Versus Doxorubicin As Palliative Chemotherapy in Patients With Advanced Hepatocellular Carcinoma From Asia

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Brivanib in Patients With Advanced Hepatocellular Carcinoma Who Were Intolerant to Sorafenib or for Whom Sorafenib Failed: Results From the Randomized Phase III BRISK-PS Study

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Sunitinib Versus Sorafenib in Advanced Hepatocellular Cancer: Results of a Randomized Phase III Trial

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JOURNAL OF CLINICAL ONCOLOGY (2013)

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Radiofrequency Ablation With or Without Transcatheter Arterial Chemoembolization in the Treatment of Hepatocellular Carcinoma: A Prospective Randomized Trial

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JOURNAL OF CLINICAL ONCOLOGY (2013)

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Effect of Antiviral Treatment With Nucleotide/Nucleoside Analogs on Postoperative Prognosis of Hepatitis B Virus-Related Hepatocellular Carcinoma: A Two-Stage Longitudinal Clinical Study

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JOURNAL OF CLINICAL ONCOLOGY (2013)

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A systematic review of radiofrequency ablation versus percutaneous ethanol injection for small hepatocellular carcinoma up to 3cm

Ai Shen et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013)

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Worse outcome of sorafenib therapy associated with ascites and Child-Pugh score in advanced hepatocellular carcinoma

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JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013)

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Stereotactic body radiation therapy combined with transcatheter arterial chemoembolization for small hepatocellular carcinoma

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JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013)

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Improved Long-Term Survival after Major Resection for Hepatocellular Carcinoma: A Multicenter Analysis Based on a New Definition of Major Hepatectomy

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JOURNAL OF GASTROINTESTINAL SURGERY (2013)

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Comparative efficacy of sorafenib versus best supportive care in recurrent hepatocellular carcinoma after liver transplantation: A case-control study

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JOURNAL OF HEPATOLOGY (2013)

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Ten-year outcomes of percutaneous radiofrequency ablation as first-line therapy of early hepatocellular carcinoma: Analysis of prognostic factors

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Feasibility and Efficacy of Stereotactic Ablative Radiotherapy for Barcelona Clinic Liver Cancer-C Stage Hepatocellular Carcinoma

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JOURNAL OF KOREAN MEDICAL SCIENCE (2013)

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Prospective Study of Transcatheter Arterial Chemoembolization for Unresectable Hepatocellular Carcinoma: An Asian Cooperative Study between Japan and Korea

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JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY (2013)

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Antiviral therapy decreases viral reactivation in patients with hepatitis B virusrelated hepatocellular carcinoma undergoing hepatectomy: a randomized controlled trial

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Article Radiology, Nuclear Medicine & Medical Imaging

Therapeutic Efficacy and Safety of Percutaneous Ethanol Injection with or without Combined Radiofrequency Ablation for Hepatocellular Carcinomas in High Risk Locations

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Regorafenib Inhibits Growth, Angiogenesis, and Metastasis in a Highly Aggressive, Orthotopic Colon Cancer Model

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MOLECULAR CANCER THERAPEUTICS (2013)

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Effects of antiviral therapy on hepatitis B virus reactivation and liver function after resection or chemoembolization for hepatocellular carcinoma

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Consensus recommendations and review by an International Expert Panel on Interventions in Hepatocellular Carcinoma (EPOIHCC)

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Effectiveness of Stereotactic Body Radiotherapy for Hepatocellular Carcinoma with Portal Vein and/or Inferior Vena Cava Tumor Thrombosis

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Perioperative Allogenenic Blood Transfusion Is Associated with Worse Clinical Outcomes for Hepatocellular Carcinoma: A Meta-Analysis

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Article Multidisciplinary Sciences

Stereotactic Body Radiation Therapy as an Alternative Treatment for Small Hepatocellular Carcinoma

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PLOS ONE (2013)

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Clinical efficacy and predictors of outcomes of repeat hepatectomy for recurrent hepatocellular carcinoma - A systematic review

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SURGICAL ONCOLOGY-OXFORD (2013)

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WORLD JOURNAL OF GASTROENTEROLOGY (2013)

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Meta-analysis of radiofrequency ablation in combination with transarterial chemoembolization for hepatocellular carcinoma

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WORLD JOURNAL OF GASTROENTEROLOGY (2013)

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Surgical Outcomes of Hepatocellular Carcinoma with Bile Duct Tumor Thrombus: A Korean Multicenter Study

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WORLD JOURNAL OF SURGERY (2013)

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Treatment for Hepatocellular Carcinoma in Elderly Patients: A Literature Review

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JOURNAL OF CANCER (2013)

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Multidisciplinary management of hepatocellular carcinoma: a model for therapy

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JOURNAL OF MULTIDISCIPLINARY HEALTHCARE (2013)

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Radiofrequency Ablation for Hepatocellular Carcinoma: 10-Year Outcome and Prognostic Factors

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AMERICAN JOURNAL OF GASTROENTEROLOGY (2012)

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Outcomes of Living and Deceased Donor Liver Transplant Recipients With Hepatocellular Carcinoma: Results of the A2ALL Cohort

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AMERICAN JOURNAL OF TRANSPLANTATION (2012)

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Value of Transient Elastography Measured With Fibroscan in Predicting the Outcome of Hepatic Resection for Hepatocellular Carcinoma

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ANNALS OF SURGERY (2012)

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The efficacy of hepatic arterial infusion chemotherapy as an alternative to sorafenib in advanced hepatocellular carcinoma

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Role of vitamin K2 in preventing the recurrence of hepatocellular carcinoma after curative treatment: A meta-analysis of randomized controlled trials

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BMC GASTROENTEROLOGY (2012)

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The use of single-agent sorafenib in the treatment of advanced hepatocellular carcinoma patients with underlying Child-Pugh B liver cirrhosis

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CANCER (2012)

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Chemoembolization With Doxorubicin-Eluting Beads for Unresectable Hepatocellular Carcinoma: Five-Year Survival Analysis

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CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY (2012)

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Palliative radiation therapy for pulmonary metastases from hepatocellular carcinoma

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CLINICAL & EXPERIMENTAL METASTASIS (2012)

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DIGESTIVE SURGERY (2012)

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Transarterial chemoembolization in very early and early-stage hepatocellular carcinoma patients excluded from curative treatment: A prospective cohort study

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EUROPEAN JOURNAL OF RADIOLOGY (2012)

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18F-FDG PET or PET/CT for detecting extrahepatic metastases or recurrent hepatocellular carcinoma: A systematic review and meta-analysis

Chun-Yi Lin et al.

EUROPEAN JOURNAL OF RADIOLOGY (2012)

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Survival after C-arm CT-assisted chemoembolization of unresectable hepatocellular carcinoma

Jin Iwazawa et al.

EUROPEAN JOURNAL OF RADIOLOGY (2012)

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Liver Transplantation for Hepatocellular Carcinoma: A Model Including α-Fetoprotein Improves the Performance of Milan Criteria

Christophe Duvoux et al.

GASTROENTEROLOGY (2012)

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Prospective validation of an immunohistochemical panel (glypican 3, heat shock protein 70 and glutamine synthetase) in liver biopsies for diagnosis of very early hepatocellular carcinoma

Silvia Tremosini et al.

GUT (2012)

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Cost-effectiveness analysis on the surveillance for hepatocellular carcinoma in liver cirrhosis patients using contrast-enhanced ultrasonography

Hironori Tanaka et al.

HEPATOLOGY RESEARCH (2012)

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Salvage Treatment With Hypofractionated Radiotherapy in Patients With Recurrent Small Hepatocellular Carcinoma

Sun Hyun Bae et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2012)

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Influence of Tumor Thrombus Location on the Outcome of External-beam Radiation Therapy in Advanced Hepatocellular Carcinoma With Macrovascular Invasion

Jia-Zhou Hou et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2012)

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Stereotactic Body Radiation Therapy in Recurrent Hepatocellular Carcinoma

Wen-Yen Huang et al.

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RADIOTHERAPY PLUS TRANSARTERIAL CHEMOEMBOLIZATION FOR HEPATOCELLULAR CARCINOMA INVADING THE PORTAL VEIN: LONG-TERM PATIENT OUTCOMES

Sangmin Yoon et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2012)

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Stereotactic Hypofractionated Radiation Therapy as a Bridge to Transplantation for Hepatocellular Carcinoma: Clinical Outcome and Pathologic Correlation

Alan W. Katz et al.

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Hepatic arterial embolization for unresectable hepatocellular carcinomas: do technical factors affect prognosis?

Koichiro Yamakado et al.

JAPANESE JOURNAL OF RADIOLOGY (2012)

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Early evaluation of transcatheter arterial chemoembolization-refractory hepatocellular carcinoma

Kenya Yamanaka et al.

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Severity and timing of progression predict refractoriness to transarterial chemoembolization in hepatocellular carcinoma

Hwi Young Kim et al.

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Role of intrahepatic tumor control in the prognosis of patients with hepatocellular carcinoma and extrahepatic metastases

Seung Min Jung et al.

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Surgical Outcome of Right Liver Donors in Living Donor Liver Transplantation: Single-Center Experience with 500 Cases

Say-June Kim et al.

JOURNAL OF GASTROINTESTINAL SURGERY (2012)

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Superselective transarterial chemoembolization for hepatocellular carcinoma. Validation of treatment algorithm proposed by Japanese guidelines

Kenichi Takayasu et al.

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A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma

Kai Feng et al.

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Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: Subanalyses of a phase III trial

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EASL Clinical Practice Guidelines: Management of chronic hepatitis B virus infection

George Papatheodoridis et al.

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Scheduled Interval Trans-Catheter Arterial Chemoembolization Followed by Radiation Therapy in Patients with Unresectable Hepatocellular Carcinoma

Jeong Il Yu et al.

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Nonsteroidal Anti-inflammatory Drug Use, Chronic Liver Disease, and Hepatocellular Carcinoma

Vikrant V. Sahasrabuddhe et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2012)

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Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

Rafael Lozano et al.

LANCET (2012)

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Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report

Pierre-Alain Clavien et al.

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Non-steroidal anti-inflammatory drugs use and risk of upper gastrointestinal adverse events in cirrhotic patients

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Sirolimus-based immunosuppression in liver transplantation for hepatocellular carcinoma: A meta-analysis

Wenhua Liang et al.

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Living donor liver transplantation versus deceased donor liver transplantation for hepatocellular carcinoma: A meta-analysis

Wenhua Liang et al.

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Opioid Metabolism

Howard S. Smith

MAYO CLINIC PROCEEDINGS (2012)

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Transarterial chemoembolization compared with conservative treatment for advanced hepatocellular carcinoma with portal vein tumor thrombus: using a new classification

Zhi-Jie Niu et al.

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Gemcitabine and oxaliplatin as second-line treatment in patients with hepatocellular carcinoma pre-treated with sorafenib

Olivier Mir et al.

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Small Hepatocellular Carcinomas: Improved Sensitivity by Combining Gadoxetic Acid-enhanced and Diffusion-weighted MR Imaging Patterns

Min Jung Park et al.

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Recurrent Hepatocellular Carcinoma Treated with Sequential Transcatheter Arterial Chemoembolization and RF Ablation versus RF Ablation Alone: A Prospective Randomized Trial

Zhen-Wei Peng et al.

RADIOLOGY (2012)

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High toxicity of sorafenib for recurrent hepatocellular carcinoma after liver transplantation

Katharina Staufer et al.

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Donor Morbidity Including Biliary Complications in Living-Donor Liver Transplantation: Single-Center Analysis of 827 Cases

Milljae Shin et al.

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Diagnostic value for extrahepatic metastases of hepatocellular carcinoma in positron emission tomography/computed tomography scan

Ji Eun Lee et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2012)

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Correlation of liver parenchymal gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid enhancement and liver function in humans with hepatocellular carcinoma

Kei Kubota et al.

ONCOLOGY LETTERS (2012)

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Role of the multidisciplinary team in the diagnosis and treatment of hepatocellular carcinoma

Robert G. Gish et al.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2012)

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Safety and efficacy of sorafenib in hepatocellular carcinoma: the impact of the Child-Pugh score

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Meta-analysis: the efficacy of anti-viral therapy in prevention of recurrence after curative treatment of chronic hepatitis B-related hepatocellular carcinoma

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ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2011)

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Liver, Gastrointestinal, and Cardiac Toxicity in Intermediate Hepatocellular Carcinoma Treated With PRECISION TACE With Drug-Eluting Beads: Results From the PRECISION V Randomized Trial

Thomas J. Vogl et al.

AMERICAN JOURNAL OF ROENTGENOLOGY (2011)

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Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis: A Prospective Comparative Study

Jun Luo et al.

ANNALS OF SURGICAL ONCOLOGY (2011)

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Locoregional Therapy-Induced Tumor Necrosis as a Predictor of Recurrence after Liver Transplant in Patients with Hepatocellular Carcinoma

Meng-Hsing Ho et al.

ANNALS OF SURGICAL ONCOLOGY (2011)

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Risk of HBV reactivation according to viral status and treatment intensity in patients with hepatocellular carcinoma

Jeong Won Jang et al.

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Comparison of open and laparoscopic live donor left lateral sectionectomy

K. H. Kim et al.

BRITISH JOURNAL OF SURGERY (2011)

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Hepatocellular Carcinoma With Extrahepatic Metastasis Clinical Features and Prognostic Factors

Koji Uchino et al.

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The Safety and Efficacy of High-Dose Proton Beam Radiotherapy for Hepatocellular Carcinoma: A Phase 2 Prospective Trial

David A. Bush et al.

CANCER (2011)

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Clinical Results and Risk Factors of Proton and Carbon Ion Therapy for Hepatocellular Carcinoma

Shohei Komatsu et al.

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Sorafenib for hepatocellular carcinoma according to Child-Pugh class of liver function

Jeong Eun Kim et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2011)

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Prognostic factors of solitary large hepatocellular carcinoma: The importance of differentiation grade

L. Zhou et al.

EJSO (2011)

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Repeated Radiofrequency Ablation for Management of Patients with Cirrhosis with Small Hepatocellular Carcinomas: A Long-Term Cohort Study

Sandro Rossi et al.

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Intention-to-Treat Analysis of Liver Transplantation for Hepatocellular Carcinoma: Living Versus Deceased Donor Transplantation

Prashant Bhangui et al.

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Ultrasonographic Surveillance of Hepatocellular Carcinoma in Cirrhosis: A Randomized Trial Comparing 3-and 6-Month Periodicities

Jean-Claude Trinchet et al.

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Efficacy of Selective Transarterial Chemoembolization in Inducing Tumor Necrosis in Small (<5 cm) Hepatocellular Carcinomas

Rita Golfieri et al.

HEPATOLOGY (2011)

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Survival After Yttrium-90 Resin Microsphere Radioembolization of Hepatocellular Carcinoma Across Barcelona Clinic Liver Cancer Stages: A European Evaluation

Bruno Sangro et al.

HEPATOLOGY (2011)

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Management of Hepatocellular Carcinoma: An Update

Jordi Bruix et al.

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Changes in hepatitis B virus DNA levels and liver function after transcatheter arterial chemoembolization of hepatocellular carcinoma

Xiang-Ming Lao et al.

HEPATOLOGY RESEARCH (2011)

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Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity

Scott M. Wilhelm et al.

INTERNATIONAL JOURNAL OF CANCER (2011)

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STEREOTACTIC BODY RADIOTHERAPY FOR PRIMARY HEPATOCELLULAR CARCINOMA

David L. Andolino et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2011)

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Focal Eosinophilic Infiltration of the Liver: Gadoxetic Acid-Enhanced Magnetic Resonance Imaging and Diffusion-Weighted Imaging

Sung Jun Ahn et al.

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY (2011)

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Clinical outcome of 251 patients with extrahepatic metastasis at initial diagnosis of hepatocellular carcinoma: Does transarterial chemoembolization improve survival in these patients?

Dong-Jun Yoo et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2011)

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Efficacy of therapy for advanced hepatocellular carcinoma: Intra-arterial 5-fluorouracil and subcutaneous interferon with image-guided radiation

Makoto Chuma et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2011)

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Optimization of imaging diagnosis of 1-2 cm hepatocellular carcinoma: An analysis of diagnostic performance and resource utilization

Korosh Khalili et al.

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Prognostic Index for Portal Vein Tumor Thrombosis in Patients with Hepatocellular Carcinoma Treated with Radiation Therapy

Jeong Il Yu et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2011)

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Change in Cancer Pain Management in Korea Between 2001 and 2006: Results of Two Nationwide Surveys

Sook Hee Hong et al.

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT (2011)

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Conventional versus Doxorubicin-eluting Bead Transarterial Chemoembolization for Hepatocellular Carcinoma

Rodolfo Sacco et al.

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY (2011)

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Noninvasive diagnostic criteria for hepatocellular carcinoma in hepatic masses > 2 cm in a hepatitis B virus-endemic area

Sung Eun Kim et al.

LIVER INTERNATIONAL (2011)

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Predictive factors for long-term survival in patients with clinically significant portal hypertension following resection of hepatocellular carcinoma

Gi H. Choi et al.

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Imaging Diagnosis and Staging of Hepatocellular Carcinoma

Jeong Min Lee et al.

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Milan Criteria in Liver Transplantation for Hepatocellular Carcinoma: An Evidence-Based Analysis of 15 Years of Experience

Vincenzo Mazzaferro et al.

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Which Matters Most: Number of Tumors, Size of the Largest Tumor, or Total Tumor Volume?

Giacomo Germani et al.

LIVER TRANSPLANTATION (2011)

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Transarterial Chemoembolization Can Be Safely Performed in Patients with Hepatocellular Carcinoma Invading the Main Portal Vein and May Improve the Overall Survival

Goh Eun Chung et al.

RADIOLOGY (2011)

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Principles of and Advances in Percutaneous Ablation

Muneeb Ahmed et al.

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Impact of Reduced Patient Life Expectancy on Potential Cancer Risks from Radiologic Imaging

David J. Brenner et al.

RADIOLOGY (2011)

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Prognostic Significance of Preoperative Imaging in Recipients of Living Donor Liver Transplantation for Hepatocellular Carcinoma

Keishi Sugimachi et al.

TRANSPLANTATION (2011)

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Meta-analysis: interferon improves outcomes following ablation or resection of hepatocellular carcinoma

A. K. Singal et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2010)

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Early Three-Dimensional Conformal Radiotherapy for Patients With Unresectable Hepatocellular Carcinoma After Incomplete Transcatheter Arterial Chemoembolization A Prospective Evaluation of Efficacy and Toxicity

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AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2010)

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Radiofrequency Ablation for the Treatment of Bone Metastases From Hepatocellular Carcinoma

Masataka Kashima et al.

AMERICAN JOURNAL OF ROENTGENOLOGY (2010)

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A Randomized Trial Comparing Radiofrequency Ablation and Surgical Resection for HCC Conforming to the Milan Criteria

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ANNALS OF SURGERY (2010)

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Complete Necrosis After Transarterial Chemoembolization Could Predict Prolonged Survival in Patients with Recurrent Intrahepatic Hepatocellular Carcinoma After Curative Resection

Ju Hyun Shim et al.

ANNALS OF SURGICAL ONCOLOGY (2010)

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Improved Results of a Surgical Resection for the Recurrence of Hepatocellular Carcinoma After Living Donor Liver Transplantation

Akinobu Taketomi et al.

ANNALS OF SURGICAL ONCOLOGY (2010)

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Vitamin Analogues in Chemoprevention of Hepatocellular Carcinoma After Resection or Ablation-A Systematic Review and Meta-analysis

Kai-Jian Chu et al.

ASIAN JOURNAL OF SURGERY (2010)

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Meta-analysis of radiofrequency ablation versus hepatic resection for small hepatocellular carcinoma

Yanming Zhou et al.

BMC GASTROENTEROLOGY (2010)

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An evidence-based multidisciplinary approach to the management of hepatocellular carcinoma (HCC): The Alberta HCC algorithm

Kelly W. Burak et al.

CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2010)

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Development of the AGREE II, part 1: performance, usefulness and areas for improvement

Melissa C. Brouwers et al.

CANADIAN MEDICAL ASSOCIATION JOURNAL (2010)

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Development of the AGREE II, part 2: assessment of validity of items and tools to support application

Melissa C. Brouwers et al.

CANADIAN MEDICAL ASSOCIATION JOURNAL (2010)

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Midterm Outcomes in Patients With Intermediate-Sized Hepatocellular Carcinoma

Manabu Morimoto et al.

CANCER (2010)

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A randomized comparative study of high-dose and low-dose hepatic arterial infusion chemotherapy for intractable, advanced hepatocellular carcinoma

Hyun Young Woo et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2010)

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Symptom Clusters and Quality of Life in Korean Patients With Hepatocellular Carcinoma

Eunjung Ryu et al.

CANCER NURSING (2010)

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Prospective Randomized Study of Doxorubicin-Eluting-Bead Embolization in the Treatment of Hepatocellular Carcinoma: Results of the PRECISION V Study

Johannes Lammer et al.

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY (2010)

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A Sustained Viral Response Is Associated With Reduced Liver-Related Morbidity and Mortality in Patients With Hepatitis C Virus

Amit G. Singal et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2010)

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Des-γ-Carboxy Prothrombin and α-Fetoprotein as Biomarkers for the Early Detection of Hepatocellular Carcinoma

Anna S. Lok et al.

GASTROENTEROLOGY (2010)

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Radioembolization for Hepatocellular Carcinoma Using Yttrium-90 Microspheres: A Comprehensive Report of Long-term Outcomes

Riad Salem et al.

GASTROENTEROLOGY (2010)

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The diagnostic and economic impact of contrast imaging techniques in the diagnosis of small hepatocellular carcinoma in cirrhosis

Angelo Sangiovanni et al.

GUT (2010)

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Loco-Regional Treatment of Hepatocellular Carcinoma

Riccardo Lencioni

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Radioembolization with Yttrium-90 Glass Microspheres in Hepatocellular Carcinoma: European Experience on Safety and Long-Term Survival

Philip Hilgard et al.

HEPATOLOGY (2010)

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COMBINATION OF TRANSARTERIAL CHEMOEMBOLIZATION AND THREE-DIMENSIONAL CONFORMAL RADIOTHERAPY FOR HEPATOCELLULAR CARCINOMA WITH INFERIOR VENA CAVA TUMOR THROMBUS

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INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2010)

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FEASIBILITY AND EFFICACY OF SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY-BASED THREE-DIMENSIONAL CONFORMAL RADIOTHERAPY FOR HEPATOCELLULAR CARCINOMA 8 CM OR MORE WITH PORTAL VEIN TUMOR THROMBUS IN COMBINATION WITH TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION

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INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2010)

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RADIATION-ASSOCIATED LIVER INJURY

Charlie C. Pan et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2010)

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AFP, AFP-L3, DCP, and GP73 as markers for monitoring treatment response and recurrence and as surrogate markers of clinicopathological variables of HCC

Kentaroh Yamamoto et al.

JOURNAL OF GASTROENTEROLOGY (2010)

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Semiannual surveillance is superior to annual surveillance for the detection of early hepatocellular carcinoma and patient survival

Valentina Santi et al.

JOURNAL OF HEPATOLOGY (2010)

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Personalized molecular targeted therapy in advanced, recurrent hepatocellular carcinoma after liver transplantation: A proof of principle

Sherrie Bhoori et al.

JOURNAL OF HEPATOLOGY (2010)

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Pain at Presentation and Survival in Hepatocellular Carcinoma

Brian I. Carr et al.

JOURNAL OF PAIN (2010)

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Predictors of Microvascular Invasion Before Hepatectomy for Hepatocellular Carcinoma

Masaki Kaibori et al.

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Chemoembolization with Lobaplatin Mixed with Iodized Oil for Unresectable Recurrent Hepatocellular Carcinoma after Orthotopic Liver Transplantation

Bin Zhou et al.

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY (2010)

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Report of a National conference on Liver Allocation in Patients with Hepatocellular Carcinoma in the United States

Elizabeth A. Pomfret et al.

LIVER TRANSPLANTATION (2010)

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Pain Management in the Cirrhotic Patient: The Clinical Challenge

Natasha Chandok et al.

MAYO CLINIC PROCEEDINGS (2010)

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Early Palliative Care for Patients with Metastatic Non-Small-Cell Lung Cancer

Jennifer S. Temel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

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Hepatic Arterial Infusion Chemotherapy Using Low-Dose 5-Fluorouracil and Cisplatin for Advanced Hepatocellular Carcinoma

Kazuomi Ueshima et al.

ONCOLOGY (2010)

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Pathology of Early Hepatocellular Carcinoma: Conventional and Molecular Diagnosis

Tania Roskams et al.

SEMINARS IN LIVER DISEASE (2010)

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Modified RECIST (mRECIST) Assessment for Hepatocellular Carcinoma

Riccardo Lencioni et al.

SEMINARS IN LIVER DISEASE (2010)

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Postoperative adjuvant antiviral therapy for hepatitis B/C virus-related hepatocellular carcinoma: A meta-analysis

Ruo-Yu Miao et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2010)

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Editorial Material Gastroenterology & Hepatology

Non-steroidal anti-inflammatory drugs: What is the actual risk of liver damage?

Fernando Bessone

WORLD JOURNAL OF GASTROENTEROLOGY (2010)

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Multidisciplinary Cancer Care With a Patient and Physician Satisfaction Focus

Gregory Litton et al.

JOURNAL OF ONCOLOGY PRACTICE (2010)

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Meta-analysis: surveillance with ultrasound for early-stage hepatocellular carcinoma in patients with cirrhosis

A. Singal et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2009)

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Repeat Radiofrequency Ablation Provides Survival Benefit in Patients With Intrahepatic Distant Recurrence of Hepatocellular Carcinoma

Yusuke Okuwaki et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2009)

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Multiphasic MDCT Enhancement Pattern of Hepatocellular Carcinoma Smaller Than 3 cm in Diameter: Tumor Size and Cellular Differentiation

Soon Ho Yoon et al.

AMERICAN JOURNAL OF ROENTGENOLOGY (2009)

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Gadoxetic Acid-Enhanced MRI Versus Triple-Phase MDCT for the Preoperative Detection of Hepatocellular Carcinoma

Seong Hyun Kim et al.

AMERICAN JOURNAL OF ROENTGENOLOGY (2009)

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Transarterial Chemoinfusion for Hepatocellular Carcinoma as Downstaging Therapy and a Bridge toward Liver Transplantation

W. De Luna et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2009)

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A Comparative Analysis of Transarterial Downstaging for Hepatocellular Carcinoma: Chemoembolization Versus Radioembolization

R. J. Lewandowski et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2009)

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Is Portal Hypertension a Contraindication to Hepatic Resection?

Alessandro Cucchetti et al.

ANNALS OF SURGERY (2009)

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Predictors of Survival After Resection of Early Hepatocellular Carcinoma

Hari Nathan et al.

ANNALS OF SURGERY (2009)

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Differentiating Early and Late Recurrences After Resection of HCC in Cirrhotic Patients: Implications on Surveillance, Prevention, and Treatment Strategies

Ronnie T. P. Poon

ANNALS OF SURGICAL ONCOLOGY (2009)

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Clinical Features and Prognostic Factors in Patients With Bone Metastases From Hepatocellular Carcinoma Receiving External Beam Radiotherapy

Jian He et al.

CANCER (2009)

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Proton Beam Therapy for Hepatocellular Carcinoma The University of Tsukuba Experience

Hidetsugu Nakayama et al.

CANCER (2009)

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Evaluation of Tumor Response After Locoregional Therapies in Hepatocellular Carcinoma Are Response Evaluation Criteria in Solid Tumors Reliable?

Alejandro Forner et al.

CANCER (2009)

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Use of Over-the-Counter Analgesics Is Not Associated With Acute Decompensation in Patients With Cirrhosis

Sakib K. Khalid et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2009)

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A randomized, controlled trial of postoperative adjuvant cytokine-induced killer cells immunotherapy after radical resection of hepatocellular carcinoma

Hui Dong et al.

DIGESTIVE AND LIVER DISEASE (2009)

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Clinical Staging of Hepatocellular Carcinoma

Volker Meier et al.

DIGESTIVE DISEASES (2009)

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New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

E. A. Eisenhauer et al.

EUROPEAN JOURNAL OF CANCER (2009)

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Percutaneous radiofrequency ablation of hepatocellular carcinoma abutting the diaphragm and gastrointestinal tracts with the use of artificial ascites: safety and technical efficacy in 143 patients

Inyoung Song et al.

EUROPEAN RADIOLOGY (2009)

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Natural history and therapeutic management of recurrent hepatocellular carcinoma after liver transplantation

A. Hollebecque et al.

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A System of Classifying Microvascular Invasion to Predict Outcome After Resection in Patients With Hepatocellular Carcinoma

Sasan Roayaie et al.

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Systematic Review of Randomized Trials for Hepatocellular Carcinoma Treated with Percutaneous Ablation Therapies

Yun Ku Cho et al.

HEPATOLOGY (2009)

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SIMULTANEOUS MULTITARGET IRRADIATION USING HELICAL TOMOTHERAPY FOR ADVANCED HEPATOCELLULAR CARCINOMA WITH MULTIPLE EXTRAHEPATIC METASTASES

Jeong Won Jang et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2009)

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A PROSPECTIVE STUDY OF HYPOFRACTIONATED PROTON BEAM THERAPY FOR PATIENTS WITH HEPATOCELLULAR CARCINOMA

Nobuyoshi Fukumitsu et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2009)

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Practical efficacy of sorafenib monotherapy for advanced hepatocellular carcinoma patients in a Hepatitis B virus-endemic area

Ju Hyun Shim et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2009)

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Evidence-Based Clinical Practice Guidelines for Hepatocellular Carcinoma in Japan: the J-HCC Guidelines

Norihiro Kokudo et al.

JOURNAL OF GASTROENTEROLOGY (2009)

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Risk factors for early and late recurrence in hepatitis B-related hepatocellular carcinoma

Jaw-Ching Wu et al.

JOURNAL OF HEPATOLOGY (2009)

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Brain metastases from hepatocellular carcinoma: prognostic factors and outcome

Hye Jin Choi et al.

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Decreased Incidence of Hepatocellular Carcinoma in Hepatitis B Vaccinees: A 20-Year Follow-up Study

Mei-Hwei Chang et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2009)

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Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial

Ann-Lii Cheng et al.

LANCET ONCOLOGY (2009)

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An Intention-To-Treat Analysis of Liver Transplantation for Hepatocellular Carcinoma Using Organ Procurement Transplant Network Data

Shawn J. Pelletier et al.

LIVER TRANSPLANTATION (2009)

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Small Hepatocellular Carcinoma: Is Radiofrequency Ablation Combined with Transcatheter Arterial Chemoembolization More Effective than Radiofrequency Ablation Alone for Treatment?

Toshiya Shibata et al.

RADIOLOGY (2009)

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Proton-Beam Therapy for Hepatocellular Carcinoma Associated with Portal Vein Tumor Thrombosis

Shinji Sugahara et al.

STRAHLENTHERAPIE UND ONKOLOGIE (2009)

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Impact of Des-Gamma-Carboxy Prothrombin and Tumor Size on the Recurrence of Hepatocellular Carcinoma After Living Donor Liver Transplantation

Akinobu Taketomi et al.

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Recurrence of hepatitis B-related hepatocellular carcinoma is associated with high viral load at the time of resection

Ivan F. N. Hung et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2008)

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Liver Transplantation for Hepatocellular Carcinoma: Results of Down-Staging in Patients Initially Outside the Milan Selection Criteria

M. Ravaioli et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2008)

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Changing paradigm in the management of hepatocellular carcinoma improves the survival benefit of early detection by screening

Albert C. Y. Chan et al.

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Liver disease induced by radioembolization of liver tumors - Description and possible risk factors

Bruno Sangro et al.

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Pilot clinical trial of localized concurrent chemoradiation therapy for locally advanced hepatocellular carcinoma with portal vein thrombosis

Kwang-Hyub Han et al.

CANCER (2008)

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Systemic therapy for hepatocellular carcinoma

Melanie B. Thomas

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Cost Effectiveness of Alternative Surveillance Strategies for Hepatocellular Carcinoma in Patients With Cirrhosis

Karin L. Andersson et al.

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Use of over-the-counter analgesics in patients with chronic liver disease - Physicians' recommendations

Simona Rossi et al.

DRUG SAFETY (2008)

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Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction

Roger K. Verbeeck

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2008)

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Neither multiple tumors nor portal hypertension are surgical contraindications for hepatocellular carcinoma

Takeaki Ishizawa et al.

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Donor morbidity after living donation for liver transplantation

Rafik M. Ghobrial et al.

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Live donors in liver transplantation

Robert S. Brown

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Needle track seeding following biopsy of liver lesions in the diagnosis of hepatocellular cancer: a systematic review and meta-analysis

M. A. Silva et al.

GUT (2008)

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Excellent outcome following down-staging of hepatocellular carcinoma prior to liver transplantation: An intention-to-treat analysis

Francis Y. Yao et al.

HEPATOLOGY (2008)

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Prediction of postoperative hepatic insufficiency by liver stiffness measurement (FibroScan) before curative resection of hepatocellular carcinoma: a pilot study

Seung Up Kim et al.

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Minimally invasive treatment combined with cytokine-induced killer cells therapy lower the short-term recurrence rates of hepatocellular carcinomas

De-Sheng Weng et al.

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A Prospective Evaluation of 18F-FDG and 11C-Acetate PET/CT for Detection of Primary and Metastatic Hepatocellular Carcinoma

Joong-Won Park et al.

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Design and endpoints of clinical trials in hepatocellular carcinoma

Josep M. Llovet et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2008)

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Preventative hepatology: minimising symptoms and optimising care

Gideon M. Hirschfield et al.

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Expanded indication criteria of living donor liver transplantation for hepatocellular carcinoma at one large-volume center

Sung-Gyu Lee et al.

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Sorafenib in advanced hepatocellular carcinoma

Josep M. Llovet et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

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Converting dose-length product to effective dose at CT

Walter Huda et al.

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Radiofrequency ablation versus ethanol injection for early hepatocellular carcinoma: A randomized controlled trial

Franco Brunello et al.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2008)

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Comparison of the outcomes between an anatomical subsegmentectomy and a non-anatomical minor hepatectomy for single hepatocellular carcinomas based on a Japanese nationwide survey

Susumu Eguchi et al.

SURGERY (2008)

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Clinical features of hepatocellular carcinoma developing extrahepatic recurrences after curative resection

Kuniya Tanaka et al.

WORLD JOURNAL OF SURGERY (2008)

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Implementation of a multidisciplinary treatment team for hepatocellular cancer at a Veterans Affairs Medical Center improves survival

Tammy T. Chang et al.

HPB (2008)

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GRADE:: going from evidence to recommendations

Gordon H. Guyatt et al.

BMJ-BRITISH MEDICAL JOURNAL (2008)

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GRADE:: what is quality of evidence and why is it important to clinicians?

Gordon H. Guyatt et al.

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GRADE:: an emerging consensus on rating quality of evidence and strength of recommendations

Gordon H. Guyatt et al.

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Safety and efficacy of lamivudine after radiofrequency ablation in patients with hepatitis B virus-related hepatocellular carcinoma

Hideo Yoshida et al.

HEPATOLOGY INTERNATIONAL (2008)

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Persistent hepatitis B viral replication affects recurrence of hepatocellular carcinoma after curative resection

Beom Kyung Kim et al.

LIVER INTERNATIONAL (2008)

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Diagnostic efficacy of gadoxetic acid (Primovist)-enhanced MRI and spiral CT for a therapeutic strategy:: comparison with intraoperative and histopathologic findings in focal liver lesions

Renate Hammerstingl et al.

EUROPEAN RADIOLOGY (2008)

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Outcomes of Neoadjuvant Transarterial Chemoembolization to Downstage Hepatocellular Carcinoma Before Liver Transplantation

William C. Chapman et al.

ANNALS OF SURGERY (2008)

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Sustained complete response and complications rates after radiofrequency ablation of very early hepatocellular carcinoma in cirrhosis: Is resection still the treatment of choice?

Tito Livraghi et al.

HEPATOLOGY (2008)

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Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: Prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma

Alejandro Forner et al.

HEPATOLOGY (2008)

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Diagnostic accuracy of tumor markers for hepatocellular carcinoma: a systematic review

Ryosuke Tateishi et al.

HEPATOLOGY INTERNATIONAL (2008)

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Expansion of selection criteria for patients with hepatocellular carcinoma in living donor liver transplantation

Takashi Ito et al.

LIVER TRANSPLANTATION (2007)

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Extending indication: Role of living donor liver transplantation for hepatocellular carcinoma

Sol Todo et al.

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Hepatitis B virus reactivation after three-dimensional conformal radiotherapy in patients with hepatitis B virus-related hepatocellular carcinoma

Ji Hoon Kim et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2007)

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Does therapeutic use of acetaminophen cause acute liver failure?

Richard C. Dart et al.

PHARMACOTHERAPY (2007)

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Seeding following percutaneous diagnostic and therapeutic approaches for hepatocellular carcinoma. What is the risk and the outcome? Seeding risk for percutaneous approach of HCC

R. Stigliano et al.

CANCER TREATMENT REVIEWS (2007)

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Analysis of prognostic factors affecting survival after initial recurrence and treatment efficacy for recurrence in patients undergoing potentially curative hepatectomy for hepatocellular carcinoma

Kazuaki Shimada et al.

ANNALS OF SURGICAL ONCOLOGY (2007)

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Recurrence of hepatocellular carcinoma after liver transplantation: Patterns and prognostic factors based on clinical and radiologic features

Young-sun Kim et al.

AMERICAN JOURNAL OF ROENTGENOLOGY (2007)

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A randomized trial to determine the change in alanine aminotransferase during 10 days of paracetamol (acetaminophen) administration in subjects who consume moderate amounts of alcohol

K. Heard et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2007)

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The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients - a multicenter randomized study

E. K. Kuffner et al.

BMC MEDICINE (2007)

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Hepatic insufficiency and mortality in 1,059 noncirrhotic patients undergoing major hepatectomy

John T. Mullen et al.

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2007)

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Radiotherapy for lymph node metastases in patients with hepatocellular carcinoma: Retrospective study

Hideomi Yamashita et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2007)

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Anatomic resection independently improves long-term survival in patients with T1-T2 hepatocellular carcinoma

Toshifumi Wakai et al.

ANNALS OF SURGICAL ONCOLOGY (2007)

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Chemoembolization of hepatocellular carcinoma with drug eluting beads:: Efficacy and doxorubicin pharmacokinetics

Maria Varela et al.

JOURNAL OF HEPATOLOGY (2007)

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Ultraselective transcatheter arterial chemoembolization with a 2-F tip microcatheter for small hepatocellular carcinomas: Relationship between local tumor recurrence and visualization of the portal vein with iodized oil

Shiro Miyayama et al.

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY (2007)

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Partial hepatectomy with wide versus narrow resection margin for solitary hepatocellular carcinoma - A prospective randomized trial

Ming Shi et al.

ANNALS OF SURGERY (2007)

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Three-quarters of right liver donors experienced postoperative complications

Nam-Joon Yi et al.

LIVER TRANSPLANTATION (2007)

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Prevalence of pain in patients with cancer: a systematic review of the past 40 years

M. H. J. Van den Beuken-Van Everdingen et al.

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Dose-volumetric parameters predicting radiation-induced hepatic toxicity in unresectable hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy

Tae Hyun Kim et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2007)

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Living donor liver transplantation for hepatocellular carcinoma: Tokyo university series

Yasuhiko Sugawara et al.

DIGESTIVE DISEASES (2007)

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Liver transplantation for hepatocellular carcinoma in patients who do not meet the Milan criteria

Kyung-Suk Suh et al.

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HCC in living donor liver transplantation: Can we expand the Milan criteria?

Choon Hyuck David Kwon et al.

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PIVKA-II is a useful tumor marker for recurrent hepatocellular carcinoma after surgical resection

Do Young Kim et al.

ONCOLOGY (2007)

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Three-dimensional conformal radiotherapy for the treatment of arteriovenous shunting in patients with hepatocellular carcinoma

H. C. Hsu et al.

BRITISH JOURNAL OF RADIOLOGY (2007)

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Three-dimensional conformal radiotherapy of unresectable hepatocellular carcinoma patients for whom transcatheter arterial chemoembolization was ineffective or unsuitable

Tae Hyun Kim et al.

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2006)

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Radiation therapy for abdominal lymph node metastasis from hepatocellular carcinoma

Young Je Park et al.

JOURNAL OF GASTROENTEROLOGY (2006)

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Transarterial chemoembolization as a bridge to liver transplantation for hepatocellular carcinoma:: An evidence-based analysis

M. Lesurtel et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2006)

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Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients

Kenichi Takayasu et al.

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Radioembolization with 90Yttrium microspheres:: A state-of-the-art brachytherapy treatment for primary and secondary liver malignancies part 1:: Technical and methodologic considerations

Riad Salem et al.

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY (2006)

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Portal hypertension:: Contraindication to liver surgery?

Lorenzo Capussotti et al.

WORLD JOURNAL OF SURGERY (2006)

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Waiting list removal rates among patients with chronic and malignant liver diseases

RB Freeman et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2006)

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Lessons learned from 1,000 living donor liver transplantations in a single center: How to make living donations safe

Shin Hwang et al.

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Lack of benefit of pretransplant locoregional hepatic therapy for hepatocellular cancer in the current MELD era

PM Porrett et al.

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Accuracy of ultrasonography, spiral CT, magnetic resonance, and alpha-fetoprotein in diagnosing hepatocellular carcinoma: A systematic review

A Colli et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2006)

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A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma

MS Chen et al.

ANNALS OF SURGERY (2006)

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Early and late recurrence after liver resection for hepatocellular carcinoma - Prognostic and therapeutic implications

N Portolani et al.

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A randomized controlled study of preemptive lamivudine in patients receiving transarterial chemo-lipiodolization

JW Jang et al.

HEPATOLOGY (2006)

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Natural history and prognostic indicators of survival in cirrhosis: A systematic review of 118 studies

G D'Amico et al.

JOURNAL OF HEPATOLOGY (2006)

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A prospective study on downstaging of hepatocellular carcinoma prior to liver transplantation

FY Yao et al.

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Acetaminophen-induced acute liver failure: Results of a United States multicenter, prospective study

AM Larson et al.

HEPATOLOGY (2005)

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Safety and efficacy of transarterial chemoembolization in patients with unresectable hepatocellular carcinoma and portal vein thrombosis

CS Georgiades et al.

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY (2005)

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Consideration of role of radiotherapy for lymph node metastases in patients with HCC: Retrospective analysis for prognostic factors from 125 patients

ZC Zeng et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2005)

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Management of hepatoceullular carcinoma

J Bruix et al.

HEPATOLOGY (2005)

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How should patients with hepatocellular carcinoma recurrence after liver transplantation be treated?

M Schwartz et al.

JOURNAL OF HEPATOLOGY (2005)

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Risk of hepatitis B exacerbation is low after transcatheter arterial chemoembolization therapy for patients with HBV-related hepatocellular carcinoma: Report of a prospective study

JW Park et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2005)

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Percutaneous ethanol injection for small hepatocellular carcinoma: Therapeutic efficacy based on 20-year observation

M Ebara et al.

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A Phase I trial of stereotactic body radiation therapy (SBRT) for liver metastases

TE Schefter et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2005)

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Randomised controlled trial comparing percutaneous radiofrequency thermal ablation, percutaneous ethanol injection, and percutaneous acetic acid injection to treat hepatocellular carcinoma of 3 cm or less

SM Lin et al.

GUT (2005)

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Characterization of small nodules in cirrhosis by assessment of vascularity: The problem of hypovascular hepatocellular carcinoma

L Bolondi et al.

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A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma

S Shiina et al.

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Impact of pretransplantation transarterial chemoembolization on survival and recurrence after liver transplantation for hepatocellular carcinoma

T Decaens et al.

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Three-dimensional conformal radiotherapy for portal vein thrombosis of hepatocellular carcinoma

DY Kim et al.

CANCER (2005)

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Radiotherapy for painful bone metastases from hepatocellular carcinoma

J Seong et al.

LIVER INTERNATIONAL (2005)

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A multicenter evaluation of utility of chest computed tomography and bone scans in liver transplant candidates with stages I and II hepatoma

B Koneru et al.

ANNALS OF SURGERY (2005)

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Coffee consumption reduces the risk of hepatocellular carcinoma independently of its aetiology: a case-control study

U Gelatti et al.

JOURNAL OF HEPATOLOGY (2005)

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Phase II study of radiotherapy employing proton beam for hepatocellular carcinoma

M Kawashima et al.

JOURNAL OF CLINICAL ONCOLOGY (2005)

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Local radiotherapy for patients with unresectable hepatocellular carcinoma

W Park et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2005)

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Article Radiology, Nuclear Medicine & Medical Imaging

Early-stage hepatocellular carcinoma in patients with cirrhosis: Long-term results of percutaneous image-guided radiofrequency ablation

R Lencioni et al.

RADIOLOGY (2005)

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Influence of coffee drinking on subsequent risk of hepatocellular carcinoma: A prospective study in Japan

M Inoue et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2005)

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Alcohol, tobacco and obesity are synergistic risk factors for hepatocellular carcinoma

JA Marrero et al.

JOURNAL OF HEPATOLOGY (2005)

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Liver resection for hepatocellular carcinoma in non-cirrhotic liver without underlying viral hepatitis

H Lang et al.

BRITISH JOURNAL OF SURGERY (2005)

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Systematic hepatectomy for small hepatocellular carcinoma in Korea

KS Suh

JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY (2005)

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Pharmacokinetics of controlled release morphine (MST) in patients with liver carcinoma

HIM Kotb et al.

BRITISH JOURNAL OF ANAESTHESIA (2005)

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Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance

A Sangiovanni et al.

GASTROENTEROLOGY (2004)

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Recurrence of hepatocellular carcinoma after liver transplant: Patterns and prognosis

S Roayaie et al.

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Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma

HB El-Serag et al.

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Hepatic arterial infusion chemotherapy with use of an implanted port system in patients with advanced hepatocellular carcinoma: Prognostic factors

A Hamada et al.

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY (2004)

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Prophylactic lamivudine administration prevents exacerbation of liver damage in HBe antigen positive patients with hepatocellular carcinoma undergoing transhepatic arterial infusion chemotherapy

H Nagamatsu et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2004)

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Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma ≤4cm

SM Lin et al.

GASTROENTEROLOGY (2004)

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Hepatitis B reactivation in patients with hepatocellular carcinoma undergoing systemic chemotherapy

W Yeo et al.

ANNALS OF ONCOLOGY (2004)

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Radiofrequency ablation of small hepatocellular carcinoma in cirrhotic patients awaiting liver transplantation -: A prospective study

V Mazzaferro et al.

ANNALS OF SURGERY (2004)

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Living donor liver transplantation for hepatocellular carcinoma

L Kulik et al.

GASTROENTEROLOGY (2004)

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Lamivudine for patients with chronic hepatitis B and advanced liver disease

YF Liaw et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

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BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

SM Wilhelm et al.

CANCER RESEARCH (2004)

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18F-FDG PET in the detection of extrahepatic metastases from hepatocellular carcinoma

M Sugiyama et al.

JOURNAL OF GASTROENTEROLOGY (2004)

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Prospective trial of combined transcatheter arterial chemoembolization and three-dimensional conformal radiotherapy for portal vein tumor thrombus in patients with unresectable hepatocellular carcinoma

K Yamada et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2003)

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Adverse events during radiofrequency treatment of 582 hepatic tumors

T de Baère et al.

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The state of the art in the 1990's: NCRP Report No. 136 on the scientific bases for linearity in the dose-response relationship for ionizing radiation

AC Upton

HEALTH PHYSICS (2003)

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A 6-month versus a 12-month surveillance for hepatocellular carcinoma in 559 hemophiliacs infected with the hepatitis C virus

E Santagostino et al.

BLOOD (2003)

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Small hepatocellular carcinoma in cirrhosis: Randomized comparison of radio-frequency thermal ablation versus percutaneous ethanol injection

RA Lencioni et al.

RADIOLOGY (2003)

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Aging reduces proliferative capacities of liver by switching pathways of C/EBPα growth arrest

P Iakova et al.

CELL (2003)

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Lamivudine therapy for hepatitis B virus reactivation in a patient receiving intra-arterial chemotherapy for advanced hepatocellular carcinoma

A Tamori et al.

HEPATOLOGY RESEARCH (2003)

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Microdissection-based allelotyping discriminates de novo tumor from intrahepatic spread in hepatocellular carcinoma

SD Finkelstein et al.

HEPATOLOGY (2003)

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Review Gastroenterology & Hepatology

Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival

JM Llovet et al.

HEPATOLOGY (2003)

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Article Gastroenterology & Hepatology

Risk factors contributing to early and date phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy

H Imamura et al.

JOURNAL OF HEPATOLOGY (2003)

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Article Surgery

Selection criteria for repeat hepatectomy in patients with recurrent hepatocellular carcinoma

M Minagawa et al.

ANNALS OF SURGERY (2003)

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Article Public, Environmental & Occupational Health

Screening for liver cancer: results of a randomised controlled trial in Qidong, China

JG Chen et al.

JOURNAL OF MEDICAL SCREENING (2003)

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Article Radiology, Nuclear Medicine & Medical Imaging

Major complications after radio-frequency thermal ablation of hepatic tumors: Spectrum of imaging findings

H Rhim et al.

RADIOGRAPHICS (2003)

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Article Gastroenterology & Hepatology

Prognostic performance of the new classification of primary liver cancer of Japan (4th edition) for patients with hepatocellular carcinoma: a validation analysis

S Ueno et al.

HEPATOLOGY RESEARCH (2002)

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Article Oncology

Therapeutic efficacy of transcatheter arterial chemoembolization as compared with hepatic resection in hepatocellular carcinoma patients with compensated liver function in a hepatitis B virus-endemic area: A prospective cohort study

HS Lee et al.

JOURNAL OF CLINICAL ONCOLOGY (2002)

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Article Gastroenterology & Hepatology

Liver transplantation for hepatocellular carcinoma: Analysis of survival according to the intention-to-treat principle and dropout from the waiting list

FY Yao et al.

LIVER TRANSPLANTATION (2002)

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Article Radiology, Nuclear Medicine & Medical Imaging

Multidisciplinary management of hepatocellular carcinoma

WS Rilling et al.

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY (2002)

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Article Surgery

Aggressive management of patients with extrahepatic and intrahepatic recurrences of hepatocellular carcinoma by combined resection and locoregional therapy

RTP Poon et al.

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2002)

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Article Medicine, General & Internal

Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma:: a randomised controlled trial

JM Llovet et al.

LANCET (2002)

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Article Oncology

Viral load is a significant prognostic factor for hepatitis B virus-associated hepatocellular carcinoma

K Ohkubo et al.

CANCER (2002)

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Article Gastroenterology & Hepatology

Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma

CM Lo et al.

HEPATOLOGY (2002)

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Long-term results with multimodal adjuvant therapy and liver transplantation for the treatment of hepatocellular carcinomas larger than 5 centimeters

S Roayaie et al.

ANNALS OF SURGERY (2002)

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Article Gastroenterology & Hepatology

Incidence and clinical outcome of icteric type hepatocellular carcinoma

JF Huang et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2002)

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Article Gastroenterology & Hepatology

Cost effectiveness of adjuvant therapy for hepatocellular carcinoma during the waiting list for liver transplantation

JM Llovet et al.

GUT (2002)

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Review Gastroenterology & Hepatology

Clinical management of hepatocellular carcinoma.: Conclusions of the Barcelona-2000 EASL Conference

J Bruix et al.

JOURNAL OF HEPATOLOGY (2001)

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Article Surgery

Liver hanging maneuver: A safe approach to right hepatectomy without liver mobilization

J Belghiti et al.

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2001)

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Article Surgery

Improving survival results after resection of hepatocellular carcinoma: A prospective study of 377 patients over 10 years

RTP Poon et al.

ANNALS OF SURGERY (2001)

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Article Gastroenterology & Hepatology

Liver transplantation for hepatocellular carcinoma: Expansion of the tumor size limits does not adversely impact survival

FY Yao et al.

HEPATOLOGY (2001)

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Article Gastroenterology & Hepatology

Living donor liver transplantation for early hepatocellular carcinoma: A life-expectancy and cost-effectiveness perspective

FP Sarasin et al.

HEPATOLOGY (2001)

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Article Surgery

Reactivation of viral replication after liver resection in patients infected with hepatitis B virus

S Kubo et al.

ANNALS OF SURGERY (2001)

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Article Oncology

New guidelines to evaluate the response to treatment in solid tumors

F Duffaud et al.

BULLETIN DU CANCER (2000)

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Article Medicine, General & Internal

Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial

T Takayama et al.

LANCET (2000)

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Article Oncology

Local radiotherapy for unresectable hepatocellular carcinoma patients who failed with transcatheter arterial chemoembolization

J Seong et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2000)

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Article Surgery

Seven hundred forty-seven hepatectomies in the 1990s: An update to evaluate the actual risk of liver resection

J Belghiti et al.

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2000)

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Article Oncology

New guidelines to evaluate the response to treatment in solid Tumors

P Therasse et al.

JOURNAL OF THE NATIONAL CANCER INSTITUTE (2000)

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Article Radiology, Nuclear Medicine & Medical Imaging

Transarterial chemoembolization for hepatocellular carcinoma: Volumetric and morphologic CT criteria for assessment of prognosis and therapeutic success - Results from a liver transplantation center

TJ Vogl et al.

RADIOLOGY (2000)

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