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PROTEIN AND PEPTIDE LETTERS (2008)
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Tracey A. Rouault et al.
TRENDS IN GENETICS (2008)
Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis
Claire Henchcliffe et al.
NATURE CLINICAL PRACTICE NEUROLOGY (2008)
Redistribution of accumulated cell iron: a modality of chelation with therapeutic implications
Yang-Sung Sohn et al.
BLOOD (2008)
Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration
Shankar J. Chinta et al.
JOURNAL OF NEUROSCIENCE (2007)
Mammalian iron metabolism
Luis G. Vallerio
TOXICOLOGY MECHANISMS AND METHODS (2007)
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin
Nicole Exner et al.
JOURNAL OF NEUROSCIENCE (2007)
Disturbance of iron metabolism as a contributing factor to SN hyperechogenicity in Parkinson's disease: Implications for idiopathic and monogenetic forms
Daniela Berg
NEUROCHEMICAL RESEARCH (2007)
Iron, copper and immunocompetence
Carlos Munoz et al.
BRITISH JOURNAL OF NUTRITION (2007)
Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death
J. Thomas Cribbs et al.
EMBO REPORTS (2007)
Copper- and iron-induced differential fibril formation in α-synuclein:: TEM study
Bharathi et al.
NEUROSCIENCE LETTERS (2007)
Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology
Chuang-Rung Chang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Direct interorganellar transfer of iron from endosome to mitochondrion
Alex D. Sheftel et al.
BLOOD (2007)
'Rejuvenation' protects neurons in mouse models of Parkinson's disease
C. Savio Chan et al.
NATURE (2007)
Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death
Sylwia Wasiak et al.
JOURNAL OF CELL BIOLOGY (2007)
Transcranial ultrasound in different monogenetic subtypes of Parkinson's disease
Katherine J. Schweitzer et al.
JOURNAL OF NEUROLOGY (2007)
Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis
Corinne Pondarre et al.
BLOOD (2007)
Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission
Naoko Taguchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Iron-dependent degradation of apo-IRP1 by the ubiquitin-proteasome pathway
Jian Wang et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Prevalence of haemochromatosis gene mutations in Parkinson's disease
Anne Hege Aamodt et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2007)
Mitochondrial toxins and neurodegenerative diseases
Antonio Ayala et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2007)
Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease
Todd B. Sherer et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Calcium, iron and neuronal function
Cecilia Hidalgo et al.
IUBMB LIFE (2007)
Paraquat exposure as an etiological factor of Parkinson's disease
R. J. Dinis-Oliveira et al.
NEUROTOXICOLOGY (2006)
Screening for mutations of the HFE gene in Parkinson's disease patients with hyperechogenicity of the substantia nigra
Nilguen Akbas et al.
NEUROSCIENCE LETTERS (2006)
Interaction of α-synuclein with divalent metal ions reveals key differences:: A link between structure, binding specificity and fibrillation enhancement
Andres Binolfi et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Association of HFE common mutations with Parkinson's disease, Alzheimer's disease and mild cognitive impairment in a Portuguese cohort
Rita J. Guerreiro et al.
BMC NEUROLOGY (2006)
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
Ira E. Clark et al.
NATURE (2006)
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
Jeehye Park et al.
NATURE (2006)
Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability
F. A. Zucca et al.
JOURNAL OF NEURAL TRANSMISSION (2006)
The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis
C Pondarré et al.
HUMAN MOLECULAR GENETICS (2006)
Parkinson's disease α-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death
LJ Martin et al.
JOURNAL OF NEUROSCIENCE (2006)
Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism
L Silvestri et al.
HUMAN MOLECULAR GENETICS (2005)
Systemic exposure to paraquat and maneb models early Parkinson's disease in young adult rats
F Cicchetti et al.
NEUROBIOLOGY OF DISEASE (2005)
Neuroprotective effects of naturally occurring biflavonoids
SS Kang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway
R Cappai et al.
FASEB JOURNAL (2005)
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress
RH Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1
MS Goldberg et al.
NEURON (2005)
Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases
HL Zheng et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Mitochondrial dysfunction and oxidative damage in parkin-deficient mice
JJ Palacino et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Enhanced substantia nigra mitochondrial pathology in human α-synuclein transgenic mice after treatment with MPTP
DD Song et al.
EXPERIMENTAL NEUROLOGY (2004)
DJ-1 has a role in antioxidative stress to prevent cell death
T Taira et al.
EMBO REPORTS (2004)
Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats
D Ben Shachar et al.
NEUROPHARMACOLOGY (2004)
Brain parenchyma sonography detects preclinical parkinsonism
U Walter et al.
MOVEMENT DISORDERS (2004)
Genetic clues to the pathogenesis of Parkinson's disease
M Vila et al.
NATURE MEDICINE (2004)
Role of dietary iron restriction in a mouse model of Parkinson's disease
CW Levenson et al.
EXPERIMENTAL NEUROLOGY (2004)
The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging
L Zecca et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
RM Canet-Avilés et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Iron, brain ageing and neurodegenerative disorders
L Zecca et al.
NATURE REVIEWS NEUROSCIENCE (2004)
Differential cytotoxicity of human wild type and mutant α-synuclein in human neuroblastoma SH-SY5Y cells in the presence of dopamine
CEH Moussa et al.
BIOCHEMISTRY (2004)
Progressive iron accumulation induces a biphasic change in the glutathione content of neuroblastoma cells
MT Nuñez et al.
FREE RADICAL BIOLOGY AND MEDICINE (2004)
Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress
Y Pesah et al.
DEVELOPMENT (2004)
Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations
M Müftüoglu et al.
MOVEMENT DISORDERS (2004)
Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition
T Yokota et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Labile iron pool: the main determinant of cellular response to oxidative stress
M Kruszewski
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2003)
Mutations in the hemochromatosis gene (HFE), Parkinson's disease and parkinsonism
MCJ Dekker et al.
NEUROSCIENCE LETTERS (2003)
Neuromelanin associated redox-active iron is increased in the substantia nigra of patients with Parkinson's disease
BA Faucheux et al.
JOURNAL OF NEUROCHEMISTRY (2003)
Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome
JR Connor et al.
NEUROLOGY (2003)
Certain metals trigger fibrillation of methionine-oxidized α-synuclein
G Yamin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Parkin mutations are frequent in patients with isolated early-onset parkinsonism
M Periquet et al.
BRAIN (2003)
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants
JC Greene et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
V Bonifati et al.
SCIENCE (2003)
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting A beta amyloid deposition and toxicity in Alzheimer disease - A pilot phase 2 clinical trial
CW Ritchie et al.
ARCHIVES OF NEUROLOGY (2003)
Oxidative stress in Parkinson's disease
P Jenner
ANNALS OF NEUROLOGY (2003)
Fe(II)-induced DNA damage in alpha-synuclein-transfected human dopaminergic BE(2)-M17 neuroblastoma cells: detection by the Comet assay
FL Martin et al.
JOURNAL OF NEUROCHEMISTRY (2003)
Characterization of cytoplasmic α-synuclein aggregates -: Fibril formation is tightly linked to the inclusion-forming process in cells
HJ Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Chemistry for an essential biological process: the reduction of ferric iron
JL Pierre et al.
BIOMETALS (2002)
The labile iron pool: Characterization, measurement, and participation in cellular processes
O Kakhlon et al.
FREE RADICAL BIOLOGY AND MEDICINE (2002)
Synergistic effects of pesticides and metals on the fibrillation of α-synuclein:: Implications for Parkinson's disease
VN Uversky et al.
NEUROTOXICOLOGY (2002)
C11-BODIPY581/591, an oxidation-sensitive fluorescent lipid peroxidation probe:: (Micro)spectroscopic characterization and validation of methodology
GPC Drummen et al.
FREE RADICAL BIOLOGY AND MEDICINE (2002)
Environmental risk factors and Parkinson's disease: Selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat
AL McCormack et al.
NEUROBIOLOGY OF DISEASE (2002)
Dopamine-dependent neurotoxicity of α-synuclein:: A mechanism for selective neurodegeneration in Parkinson disease
J Xu et al.
NATURE MEDICINE (2002)
Magnesium inhibits spontaneous and iron-induced aggregation of α-synuclein
N Golts et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Selective determination of mitochondrial chelatable iron in viable cells with a new fluorescent sensor
F Petrat et al.
BIOCHEMICAL JOURNAL (2002)
Brain iron pathways and their relevance to Parkinson's disease
D Berg et al.
JOURNAL OF NEUROCHEMISTRY (2001)
Echogenicity of the substantia nigra in Parkinsons disease and its relation to clinical findings
D Berg et al.
JOURNAL OF NEUROLOGY (2001)
Subcellular distribution of chelatable iron: a laser scanning microscopic study in isolated hepatocytes and liver endothelial cells
F Petrat et al.
BIOCHEMICAL JOURNAL (2001)
Iron and neurodegenerative disorders
KJ Thompson et al.
BRAIN RESEARCH BULLETIN (2001)
Inducible expression of mutant α-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis
Y Tanaka et al.
HUMAN MOLECULAR GENETICS (2001)
Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages:: consequences for iron storage and neurodegenerative processes
L Zecca et al.
JOURNAL OF NEUROCHEMISTRY (2001)
Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space
D Han et al.
BIOCHEMICAL JOURNAL (2001)
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
R Betarbet et al.
NATURE NEUROSCIENCE (2000)
Mitochondrial free radical generation, oxidative stress, and aging
E Cadenas et al.
FREE RADICAL BIOLOGY AND MEDICINE (2000)
α-synuclein promotes mitochondrial deficit and oxidative stress
LJ Hsu et al.
AMERICAN JOURNAL OF PATHOLOGY (2000)
Association between early-onset Parkinson's disease and mutations in the parkin gene
CB Lücking et al.
NEW ENGLAND JOURNAL OF MEDICINE (2000)
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