Journal
SCIENCE OF ADVANCED MATERIALS
Volume 14, Issue 5, Pages 829-835Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/sam.2022.4251
Keywords
Endometrial Cancer; Nanoparticle Albumin-Bound Paclitaxel; Cell Proliferation
Funding
- Norman Bethune Medical Science Research Fund [B19006CS]
- Natural Science Foundation of Fujian Province [2018J01265]
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This study compared the antitumor efficacy and toxicity of nab-paclitaxel and paclitaxel, and found that nab-paclitaxel was more effective in inhibiting cancer cell growth, inducing apoptosis, and causing G1 arrest in the cell cycle.
Nab-paclitaxel is a water-soluable formulation of paclitaxel. It is more effective and less toxic than paclitaxel in treating cancer. Here we compared nab-paclitaxel with paclitaxel for their antitumor efficacy and toxicity in vitro and in a murine endometrial cancer model. Nab-paclitaxel was more effective than paclitaxel in inhibiting cancer cell growth. Nab-paclitaxel also caused cell apoptosis and cell cycle G1 arrest more effectively than paclitaxel. Similar effect was observed in mice model of endometrial cancer. In summary this preliminary study shows nab-paclitaxel is a promising therapeutic agent for endometrial cancer and deserves further studies.
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