Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 23, Issue 7, Pages 1031-1034Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458516667565
Keywords
Multiple sclerosis; clinically isolated syndrome; magnetic resonance imaging; diagnostic criteria
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Funding
- United Kingdom MS Society
- NIHR University College London Hospitals Biomedical Research Centre
- National Institute for Health Research [NF-SI-0508-10058] Funding Source: researchfish
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In patients who present with a clinically isolated syndrome (CIS), whose features are suggestive of multiple sclerosis (MS), fulfilling McDonald 2010 magnetic resonance imaging (MRI) criteria for dissemination in space (DIS) and dissemination in time (DIT) enables a diagnosis of MS. While 1 periventricular lesion is included in the 2010 DIS criteria, earlier McDonald criteria required 3 periventricular lesions to confirm DIS and recent Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS)-recommended DIS criteria also require 3 lesions. We investigated the effect of varying the required number of periventricular lesions and found that the best combination of specificity and sensitivity for clinically definite MS was seen for 1 periventricular lesion using both the McDonald 2010 and MAGNIMS 2016 criteria.
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