Journal
MEDICINE
Volume 101, Issue 50, Pages -Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MD.0000000000032237
Keywords
coronary heart disease; meta-analysis; protocol; randomized trial; Tiaogan formula
Categories
Funding
- Basic and Applied Basic Research Foundation of Guangdong Province [2022A1515011647]
- Scientific Research Project of Traditional Chinese Medicine Bureau of Guangdong Province [20221354]
- Guangdong Medical Science and Technology Research Foundation Project [C2021102]
- Shenzhen Science and Technology Program [JCYJ20210324111213038]
- Sanming Project of Medicine in Shenzhen, Guangdong Province, China [SZSM201612074, SZSM201612033]
- Shenzhen Traditional Chinese Medicine Hospital 3030 Program
- Chinese Medicine Clinical Research Project [G3030202133]
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This article presents a systematic review and meta-analysis aiming to assess the effectiveness and safety of Tiaogan formula in patients with coronary heart disease (CHD). The study will conduct a systematic search and data synthesis, and evaluate the quality of evidence using a rigorous assessment system.
Background:The morbidity and mortality of coronary heart disease (CHD) has remained high, which greatly increases people's economic burden. Several studies have showed that Tiaogan formula (TGF), as a kind of Chinese herbal medicine, was of benefit to relieving angina pectoris symptoms and improving the quality of life for CHD patients. However, the intensity of evidence has been poor, limiting the further clinical application of TGF to CHD. This systematic review and meta-analysis will assess the effectiveness and safety of studies of TGF in CHD patients. Methods:A systematic search for literature up to December 2022 will be conducted in following public electronic databases: PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure, Chinese Scientific Journals Database Database, and Wanfang Database. Inclusion criteria are randomized controlled trials of Tiaogan formula in the treatment of coronary heart disease. The primary outcome measures will be mortality, acute cardiovascular events, total efficacy rate, and improvement of angina symptoms. The secondary outcome measures will be electrocardiogram, levels of blood lipid, and adverse events. RevMan 5.4 software Cochrane Collaboration (London, United Kingdom) will be applied for data synthesis, sensitivity analysis, subgroup analysis, and risk of bias assessment. A funnel plot will be developed to evaluate reporting bias and Egger tests will be used to assess funnel plot symmetries. We will use the Grading of Recommendations Assessment, Development and Evaluation system to assess the quality of evidence. Results:This study will provide a systematic review of Tiaogan formula in the treatment of CHD. Conclusion:This study will provide a high-quality synthesis of the effects and safety of Tiaogan formula in the treatment of CHD patients.
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