Journal
JAMA PEDIATRICS
Volume 170, Issue 4, Pages 381-390Publisher
AMER MEDICAL ASSOC
DOI: 10.1001/jamapediatrics.2015.4430
Keywords
-
Categories
Funding
- European Community [241604]
- Developing a Child Cohort Research Strategy for EuropeProject
- Netherlands Organisation for Health Research and Development [ZonMw 40-00812-98-11010]
- Foundation for Medical Research
- National Agency for Research
- National Institute for Research in Public Health
- French Ministry of Health
- French Ministry of Research
- French Institute of Health and Medical Research Bone
- Joint Diseases National Research (PRO-A)
- Paris-Sud University
- Nestle
- French National Institute for Population Health Surveillance
- French National Institute for Health Education
- European Union
- Diabetes National Research Program
- French Agency for Environmental Health Safety
- Mutuelle Generale de l'Education Nationale a Complementary Health Insurance
- French National Agency for Food Security
- French Speaking Association for the Study of Diabetes and Metabolism
- Ministry of the Flemish Community
- Italian Ministry of Health
- Erasmus Medical Center, Rotterdam
- Erasmus University Rotterdam
- Netherlands Organisation for Scientific Research
- Ministry of Health, Welfare, and Sport
- Ministry of Youth and Families
- Programa Operacional de Saude XXI
- Quadro Comunitario de Apoio III
- Administracao Regional de Saude Norte (Regional Department of Ministry of Health)
- Portuguese Foundation for Science and Technology
- Fundo Europeu De Desenvolvimento Regional
- Calouste Gulbenkian Foundation
- Norwegian Ministry of Health
- Ministry of Education and Research
- National Institutes of Health/National Institute for Environmental Health Sciences [NO1-ES-75558]
- National Institutes of Health/National Institute of Neurological Disorders and Stroke [1 UO1 NS 047537-01, 2 UO1 NS047537-06A1]
- Norwegian Research Council/Funksjonell genomforskning [213148, 151918/S10]
- Instituto de Salud Carlos III [Red INMA G03/176, CB06/02/0041]
- Spanish Ministry of Health
- Generalitat de Catalunya Interdepartmental Committee for Research and Technological Innovation [1999SGR00241]
- Conselleria de Sanitat Generalitat Valenciana
- Department of Health of the Basque Government [2005111093, 2009111069]
- Provincial Government of Gipuzkoa [DFG06/004, DFG08/001]
- Dutch Board of Health Insurance Companies
- Triodos Foundation
- Phoenix Foundation
- Raphael Foundation
- Iona Foundation
- Foundation for the Advancement of Heilpedagogie
- Health Research Board
- Republic of Ireland
- Compagnia di San Paolo Foundation
- Italian Ministry of University and Research
- Netherlands Asthma Fund
- Netherlands Ministry of Spatial Planning, Housing, and the Environment
- Netherlands Ministry of Health, Welfare, and Sport
- US National Institutes of Health [R01 HL075504, R37 HD 034568, R01 ES016314]
- National Science Centre [UMO-2014/15/B/NZ7/00998]
- Greek Ministry of Health
Ask authors/readers for more resources
IMPORTANCE Maternal fish intake in pregnancy has been shown to influence fetal growth. The extent to which fish intake affects childhood growth and obesity remains unclear. OBJECTIVE To examine whether fish intake in pregnancy is associated with offspring growth and the risk of childhood overweight and obesity. DESIGN, SETTING, AND PARTICIPANTS Multicenter, population-based birth cohort study of singleton deliveries from 1996 to 2011 in Belgium, France, Greece, Ireland, Italy, the Netherlands, Norway, Poland, Portugal, Spain, and Massachusetts. A total of 26 184 pregnant women and their children were followed up at 2-year intervals until the age of 6 years. EXPOSURES Consumption of fish during pregnancy. MAIN OUTCOMES AND MEASURES We estimated offspring body mass index percentile trajectories from 3 months after birth to 6 years of age. We defined rapid infant growth as a weight gain z score greater than 0.67 from birth to 2 years and childhood overweight/obesity at 4 and 6 years as body mass index in the 85th percentile or higher for age and sex. We calculated cohort-specific effect estimates and combined them by random-effects meta-analysis. RESULTS This multicenter, population-based birth cohort study included the 26 184 pregnant women and their children. The median fish intake during pregnancy ranged from 0.5 times/week in Belgium to 4.45 times/week in Spain. Women who ate fish more than 3 times/week during pregnancy gave birth to offspring with higher body mass index values from infancy through middle childhood compared with women with lower fish intake (3 times/week or less). High fish intake during pregnancy (>3 times/week) was associated with increased risk of rapid infant growth, with an adjusted odds ratio (aOR) of 1.22 (95% CI, 1.05-1.42) and increased risk of offspring overweight/obesity at 4 years (aOR, 1.14 [95% CI, 0.99-1.32]) and 6 years (aOR, 1.22 [95% CI, 1.01-1.47]) compared with an intake of once per week or less. Interaction analysis showed that the effect of high fish intake during pregnancy on rapid infant growth was greater among girls (aOR, 1.31 [95% CI, 1.08-1.59]) than among boys (aOR, 1.11 [95% CI, 0.92-1.34]; P = .02 for interaction). CONCLUSIONS AND RELEVANCE High maternal fish intake during pregnancy was associated with increased risk of rapid growth in infancy and childhood obesity. Our findings are in line with the fish intake limit proposed by the US Food and Drug Administration and Environmental Protection Agency.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available