Journal
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
Volume 68, Issue 6, Pages 513-520Publisher
CENTER ACADEMIC PUBL JAPAN
Keywords
sudachi; essential oil; proliferation; antigen-presentation; dendritic cell
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Funding
- JSPS KAKENHI [JP22K11701, JP22K17778]
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Sudachi oil can suppress immune function both in vitro and in vivo, including cell proliferation and antigen presentation, leading to the inhibition of antigen-specific T cell induction.
The essential oil of Citrus sudachi (sudachi oil) is extracted from the peel of sudachi, a citrus plant. We investigated the effect of sudachi oil on immune function in both in vitro antigen (Ag) induced lymphocyte activation and in vivo Ag-specific immune response. In the in vitro study, the proliferative activity of splenocytes upon Ag-specific and non-specific stimulation was suppressed by treatment with sudachi oil in a dose-dependent manner. In addition, the expression level of Ag-presentation-related molecules and their Ag-presenting function on dendritic cells were suppressed by sudachi oil. To examine how sudachi oil regulates an Ag-specific immune response in vivo, mice were immunized with ovalbumin and the immune response of the mice was investigated. Ag-specific proliferation response of splenocytes from mice treated with sudachi essential oil was significantly sup-pressed. The results indicate that sudachi oil suppresses T cell and dendritic cell functions in vitro and Ag-specific T cell induction in vivo.
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