Journal
MACROHETEROCYCLES
Volume 15, Issue 4, Pages 207-302Publisher
IVANOVO STATE UNIV CHEMICAL TECHNOLOGY
DOI: 10.6060/mhc224870k
Keywords
Photodynamic therapy; antimicrobial photodynamic therapy; tetrapyrrolic macroheterocyclic compounds; porphyrins; phthalocyanines; chlorins; bacteriochlorins; synthesis; photosensitizers; optical properties; proteins; SARS-CoV-2; photoinactivation; optochemical diagnostics; self-assembling; nanostructures; Langmuir-Schefer films; extraligation; quantum dots; singlet oxygen generation; amphiphilic polymers; diagnostics; clinical application of PDT
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Funding
- Ministry of Science and Higher Education of the Russian Federation [FZZW-2020-0008, 075-00697-22-00, 0706-2020-0019, 075-15-2022-315]
- Russian Science Foundation [21-73-10230, 21-73-20140, 19-13-00410-P, 20-12-00175, 22-23-00903, 22-73-10176]
- State assignment via the Research scientific laboratory of Chemistry of natural products and their synthetic analogues of Scientific Educational Centre Technoplatform 2035 [FSWR-2021-014]
- Institute of Chemistry of the Komi Research Center of the Ural Branch of the Russian Academy of Sciences (Syktyvkar) [122040600073-3]
- BSPSR program Photonics and Electronics for Innovations (Belarus)
- Volkswagen Foundation
- Visiting Scholar Program of TU Chemnitz, Germany
- Russian Foundation for Basic Research [20-03-00153, 20-02-00928]
- Ministry of Science and Higher Education of Russia [07-515-2021-671]
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This review provides an overview of the wide application of tetrapyrrole photosensitizers in photodynamic therapy, antimicrobial photodynamic therapy, and photoinactivation of pathogens. The synthesis methods and design of new photosensitizers to enhance their selectivity in tumor tissue and their photoinduced antitumor activity are discussed. The review also examines the properties of new photosensitizers, their photoactivity, the generation of singlet oxygen, and the potential use of targeted photodynamic therapy in clinical practice.
This review presents a wide range of tetrapyrrole photosensitizers used for photodynamic therapy (PDT), antimicrobial photodynamic therapy, photoinactivation of pathogens. Methods of synthesis and design of new photosensitizers with greater selectivity of accumulation in tumor tissue and increased photoinduced antitumor activity are considered. The issues of studying the properties of new photosensitizers, their photoactivity, the ability to generate singlet oxygen, and the possibility of using targeted photodynamic therapy in clinical practice are discussed. The review examines the work on PDT by national and foreign researchers.
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