Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 4, Issue 10, Pages 1757-1769Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5tb02135a
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Funding
- National Basic Research Program of China [2012CB933301, 2013CB933802]
- National Natural Science Foundation of China [21305070, 21475064, 21373260, 91123037]
- Natural Science Foundation of Jiangsu Province [BK20130861]
- Scitech Support Plan of Jiangsu Province [BE2014719]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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Detection of nucleic acid and protein targets related to human health and safety has attracted widespread attention. Surface-enhanced Raman scattering (SERS) is a powerful tool for biomarker detection because of its ultrahigh detection sensitivity and unique fingerprinting spectra. In this review, we first introduce the development of nanostructure-based SERS-active substrates and SERS nanotags, which greatly influence the performance of SERS biosensors. We then focus on recent advances in SERS biosensors for DNA, microRNA and protein determination, including label-free, labeled and multiplex analyses as well as in vivo imaging. Finally, the prospects and challenges of such nanostructure-based SERS biosensors are discussed.
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