Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 4, Issue 16, Pages 2819-2827Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6tb00459h
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Funding
- Fundamental Research Funds for the Central Universities [30915011312, 30915012207]
- QingLan Project, Jiangsu Province, China
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Industrial Research Project [CG1421]
- Science and Technology Bureau of Lianyungang City
- Prospective Joint Research Project, Jiangsu Province, China [BY2015050-01]
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We constructed triple-stimuli-responsive nanocontainers (T-SRNs), consisting of mesoporous silica nanoparticles for accommodating cargoes and bistable [2]pseudorotaxanes for regulating cargoes and realizing controlled release. T-SRNs eliminate premature leakage of model cargoes under neutral solution conditions by the formation of complexes of water-soluble carboxylate-substituted pillar[5]arenes (WP5) with 1,6-hexanediammonium (HDA) recognition stations to block pore orifices. After exposure to acid, alkali pH or Zn2+ environments, T-SRNs release encapsulated cargoes promptly, which can be attributed to the dethreading of WP5 from HDA sites by different approaches and the lack of stoppers. The unique acid/alkali/Zn2+-responsive controlled release characteristic mean that T-SRNs have potential in some application fields. Herein, MTT assays and in vitro release of doxorubicin from T-SRNs demonstrate that T-SRNs can serve as promising targeted drug delivery vehicles.
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