Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 4, Issue 1, Pages 87-95Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5tb02023a
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Funding
- National Basic Research Program of China (973 program) [2013CB733700]
- National Science Foundation of China [21201038, 21231004]
- Shanghai Sci. Tech. Comm. [12ZR1440600, 15QA1400700]
- Fudan University's Undergraduate Research Opportunities Program (FDUROP) [14026]
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The fluorescent probes working in the near-infrared (NIR) window have unparalleled advantages of a high penetration depth and low interference from autofluorescence. In this paper we introduced a rare-earth doped nanoprobe working in this region with a narrow emission band, a high efficiency, and good bio-compatibility. The newly-developed host material LiYF4 managed to strengthen the emission intensity and generate a fine structure of the emission peaks. After the optimization of the doping ratio of Nd3+ and surface modification, the LiYF4: 5%Nd3+ probe could reach a penetration depth of 3-5 mm and could be successfully utilized in lymphatic imaging, with a signal-to-noise ratio of 14.8 in vivo and a resolution of similar to 0.2 mm in circulatory imaging. This probe may be further used in bio-detection and the host material itself may replace the traditional NaYF4 in some aspects of applications.
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