Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 4, Issue 6, Pages 1035-1039Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5tb02004b
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Funding
- Howard Hughes Medical Institute
- NSF [DMR 1408955]
- Burroughs Wellcome Fund Postdoctoral Enrichment Program award
- NIH postdoctoral fellowship [5 F32 HL121986-02]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [F32HL121986] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE016523] Funding Source: NIH RePORTER
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We present a versatile and facile method to enhance user-control of small molecule drug release from a poly(ethylene glycol)-based hydrogel using the host/guest complex formed between an azobenzene derivative guest and a beta-cyclodextrin host. A model drug is formed from a short peptide containing a fluorophore and an azobenzene functional group on one terminus. Upon irradiation with UV light, azobenzene isomerization leads to decreased complex formation and an on-demand acceleration of the release rate of an entrapped model drug.
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