Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 4, Issue 39, Pages 6454-6461Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6tb01534d
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Funding
- Independent Study Projects of the State Key Laboratory of Pulp and Paper Engineering [2015C08, 2015ZD03]
- Science and Technology Program of Guangzhou, China [201504010033]
- New Century Excellent Talents in University [NCET-13-0215]
- Fundamental Research Funds for the Central Universities, SCUT [201522036]
- Opening Project of the Key Laboratory of Polymer Processing Engineering, Ministry of Education, China [KFKT-201401]
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Nanostructures encapsulating multiple quantum dots (QDs) are of special interests for live cell imaging and biomolecular recognition due to their inherent signal amplification. In this study, a novel type of biomass-based nanomicelles was prepared and characterized for facile loading and solubilization of fluorescent hydrophobic CdSe/ZnS QDs in water. The biobased nanomicelles were formed by the self assembly of amphiphilic cellulose-graft-poly (p-dioxanone) (MCC-g-PPDO) synthesized via homogeneous ring-opening polymerization in an ionic liquid. Through a simple physical loading method, multiple lipophilic CdSe/ZnS QDs can be simultaneously encapsulated in one MCC-g-PPDO micelle showing an obviously enlarged micelle size, whereas the loaded QDs exhibited a negligible change in their size and size distribution. The QDs-loaded cellulosic micelles exhibited good optical stability, narrow emission bandwidth as well as an acceptable quantum yield of similar to 27%. Successful tumor cell internalization and negligible cytotoxicity were observed with these light-emitting cellulosic micelles. It was found that over 90% of the cells were viable after 24 h of exposure and the fluorescent signal inside the cells reached a maximum after 2 h of exposure. These QDs-loaded cellulosic nanomicelles derived from biomass are a promising candidate for bioimaging or other functional applications.
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