Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 4, Issue 46, Pages 7379-7386Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6tb02384c
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Funding
- National Natural Science Foundation of China [21301011, 21542017, 21601076]
- Key Laboratory Program of Educational Department of Liaoning Province [LZ2015047]
- Natural Science Foundation of Liaoning Province [201602400]
- State Key Laboratory of Fine Chemicals [KF1305]
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Molecular imaging is a powerful tool to visualize cellular processes and activity levels of biomarkers at the cellular and molecular level, in which a molecular probe is a prerequisite for the molecular imaging technique. The present work reports a bimodal probe for the fluorescence and magnetic resonance detection of fluoride ions (F-) in aqueous media and in vivo. The bimodal probe, EDTA-Gd-HF, was prepared by self-assembly of the EDTA-Gd complex with 3-hydroxyflavone (HF). In the system, HF plays the role of spectroscopic reporter and Gd(III) serves as a MRI signal output unit as well as the fluoride ion binding site. Upon addition of fluoride ions into an aqueous solution of EDTA-Gd-HF, the replacement of one coordinated water molecule and then liberation of HF led to remarkable spectroscopic recovery and distinct changes to the longitudinal relaxivity (r1), by which fluorescence/MRI bimodal fluoride ion sensing was achieved. In vivo magnetic resonance imaging (MRI) in mice indicates that EDTA-Gd-HF can be potentially used in biomedical diagnosis and therapy fields.
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