Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 4, Issue 11, Pages 2051-2058Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5tb02551f
Keywords
-
Categories
Funding
- Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology [CE140100036]
Ask authors/readers for more resources
In this study, the antibacterial efficacy of NO-releasing porous silicon nanoparticles (pSiNPs) is reported. NO-releasing pSiNPs were produced via the conjugation of S-nitrosothiol (SNO) and S-nitrosoglutathione (GSNO) donors to the nanoparticle surfaces. The release of the conjugated NO caused by the decomposition of the conjugated SNO and GSNO was boosted in the presence of ascorbic acid. The released NO was bactericidal to Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli), and eliminated bacterial growth within 2 h of incubation without compromising the viability of mammalian cells. These results demonstrate the advantages of NO-releasing pSiNPs for antibacterial applications, for example, in chronic wound treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available