Journal
INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH
Volume 15, Issue -, Pages -Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/11786469221128697
Keywords
Hesperidin; kynurenine; skin temperature; leukocyte; inflammation; depression; mouse; lipopolysaccharide
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The present study found that hesperidin, a citrus flavonoid, can suppress the activation of the tryptophan-kynurenine pathway in the brain and reduce LPS-induced signs of illness. However, it does not improve body weight loss, food and water intake, or splenic increases in leukocyte numbers.
Depressive disorders are partially attributed to chronic inflammation associated with the tryptophan (Trp)-kynurenine (Kyn) pathway. Recent evidence suggests that anti-inflammatory agents may reduce the risk of depression. The present study aimed to elucidate the potential of the citrus flavonoid hesperidin, which exhibits anti-inflammatory activity, in suppressing the Trp-Kyn pathway in the brain, using a lipopolysaccharide (LPS)-induced inflammation mouse model. Dietary hesperidin was found to suppress activation of the Trp-Kyn pathway in the prefrontal cortex. In addition, it reduced systemic LPS-induced signs of illness, such as low skin temperature and enhanced leukocyte count in the blood. However, dietary supplementation with hesperidin did not improve body weight loss, food intake, water intake, or splenic increases in leukocyte numbers in the LPS model. Collectively, the results suggest that dietary hesperidin can partially regulate central and peripheral events linked to inflammation in LPS mouse models.
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