Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 4, Issue 1, Pages 113-120Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5tb02041g
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Funding
- 973 program [2014CB660808]
- Key University Science Research Project of Jiangsu Province [15KJA430006]
- Jiangsu Provincial Founds for Distinguished Young Scholars [BK20130046]
- NNSF of China [61525402, 21275076, 61328401, 51103074]
- Program for New Century Excellent Talents in University [NCET-13-0853]
- Qing Lan Project, Synergetic Innovation Center for Organic Electronics and Information Displays, the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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Specific targeting towards tumors and the on-site activation of photosensitizers to diagnose tumors and reduce side effects for patients are currently the main challenges for photodynamic therapy (PDT) in the clinic. Herein, uniform diiodostyryl bodipy conjugated hyaluronic acid nanoparticles (DBHA-NPs) were successfully synthesized. The evaluation of their PDT effect at both a cellular level and in animal models of tumor-bearing mice shows that the DBHA-NPs present a remarkable suppression of tumorous growth due to their specific targeting and enhanced permeability and retention (EPR) effect. More importantly, the enzyme-activated self-assembly and disaggregation'' behavior in tumors can lead to the on-site activation of DBHA-NPs, which can diagnose the tumor exactly and reduce the side effects for patients significantly. These findings confirm that DBHA-NPs have significant potential for photodynamically activated cancer theranostics in a clinical setting.
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