Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 4, Issue 16, Pages 2768-2775Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6tb00247a
Keywords
-
Categories
Funding
- Natural Science Foundation of China (NSFC Project) [21434008]
Ask authors/readers for more resources
With its clinically-demonstrated safety profile and huge potential for functionalization, albumin should be an ideal biomaterial. In this study, we obtained disulfide-crosslinked albumin hydrogels using the protein's own thiol groups. In the water solutions with denaturants such as urea and guanidinium, the disulfide-crosslinked albumin hydrogels showed a normal swelling profile. However, in water solutions without denaturants, the same hydrogels showed erosion behavior similar to the physical gels. We explained these rich swelling behaviors by proposing that an inter-to-intramolecular disulfide exchange occurred in the eroding hydrogel. The albumin hydrogels are injectable through narrow needles and a doxorubicin-releasing study was used to demonstrate their potential applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available