Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 4, Issue 33, Pages 5567-5574Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6tb00638h
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Funding
- Agence Nationale pour la Recherche [ANR-10-NANO-022-01, ANR-12-NANO-0017]
- Conseil Regional d'Aquitaine
- Agence Nationale de la Recherche (ANR) [ANR-12-NANO-0017] Funding Source: Agence Nationale de la Recherche (ANR)
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The synthesis of ethenylene-based periodic mesoporous organosilica nanoparticles for two-photon imaging and photodynamic therapy of breast cancer cells is described. A dedicated two-photon absorbing fluorophore possessing four triethoxysilyl groups and having large two-photon absorption in the near IR region, and azidopropyltriethoxysilane were incorporated into the structure. The mesoporous nanoparticles of 100 nm diameter were further functionalized by means of click chemistry with a propargylated fluorescent bromo-quinoline photosensitizer able to generate singlet oxygen. The photophysical properties and two-photon absorption properties of the nanoparticles were investigated evidencing complementary contribution of the two dyes. Both dyes contribute to the two-photon absorption response of the mesoporous nanoparticles while efficient FRET from the two-photon fluorophore to the quinoline sensitizer is observed. The dual-functionalized nanoparticles were incubated with MCF-7 breast cancer cells. Two-photon confocal imaging demonstrated the endocytosis of the nanoparticles within cancer cells. Moreover, brief two-photon irradiation (3 scans of 1.57 s) at 760 nm at high laser power (3 W) was shown to induce 40% of cancer cell death demonstrating the potential of the dual-functionalized mesoporous organosilica nanoparticles for two-photon photodynamic therapy.
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