Journal
AMERICAN JOURNAL OF CANCER RESEARCH
Volume 12, Issue 7, Pages 3034-+Publisher
E-CENTURY PUBLISHING CORP
Keywords
Chemokine; chemokine receptors; gastric cancer; prognosis; immune infiltrates
Categories
Funding
- Science and Technology Projects Funding of Zhongshan Science and Technology Bureau [2018B1031]
Ask authors/readers for more resources
This study explored the role of chemokine and chemokine receptors (CCRs) in gastric cancer (GC) by analyzing datasets from the TCGA database. It found that CCRs play a significant role in tumor infiltration, angiogenesis, and metastasis in GC. A prediction model based on four CCRs (CCL15, CCL21, CCR3, and ACKR3) was constructed and showed potential as an independent prognostic factor for GC. The study also revealed the correlation between CCRs and immune-cell infiltration in the GC immune microenvironment.
Chemokine and chemokine receptors (CCRs) play a significant role in tumor infiltration of immune cells, tumor angiogenesis and distant metastasis. In this study, we explored the importance of CCRs in gastric cancer (GC) by analyzing the datasets from TCGA database. First, we analyzed the characteristics of the CCRs mutations. Then, we screened the differentially expressed CCRs and performed GO functional annotation and KEGG pathway analyses to explore their potential biological functions. Using multivariate Cox regression analyses, we constructed a prediction model based on four-CCRs (CCL15, CCL21, CCR3 and ACKR3) signature, and we found that the risk score of the model was an independent prognostic factor of GC. Next, a nomogram was constructed to assess the prognosis of GC patients. GSEA indicated that the high-risk group was significantly enriched in immune response and immune system process. Moreover, GSVA was employed to investigate the up- and down-regulated signaling pathways in the high- and low-risk groups. The correlation between risk score and immune-cell infiltration indicated that the four-CCRs signature might play a pivotal role in GC immune microenvironment. In conclusion, we revealed the potential molecular mechanisms of CCRs in GC and constructed a prediction model which might guide personalized treatment and prognosis for GC patients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available